In:
ERJ Open Research, European Respiratory Society (ERS), Vol. 9, No. 4 ( 2023-07), p. 00135-2023-
Abstract:
This study evaluated the risk factors of long-term mortality in patients with multidrug/rifampicin-resistant tuberculosis (MDR/RR-TB) in South Korea who were lost to follow-up (LTFU). Methods This was a retrospective longitudinal follow-up study using an integrated database constructed by data linkage of the three national databases, which included 7226 cases of MDR/RR-TB notified between 2011 and 2017 in South Korea. Post-treatment outcomes of patients who were LTFU were compared with those of patients who achieved treatment success. Results Of the 7226 MDR/RR-TB cases, 730 (10.1%) were LTFU. During a median follow-up period of 4.2 years, 101 (13.8%) of the LTFU patients died: 25 deaths (3.4%) were TB related and 76 (10.4%) were non-TB related. In the LTFU group, the adjusted hazard ratio (aHR) of all-cause mortality (aHR 2.50, 95% CI 1.99–3.15, p 〈 0.001), TB-related mortality (aHR 5.38, 95% CI 3.19–9.09, p 〈 0.001) and non-TB-related mortality (HR 2.21, 95% CI 1.70–2.87, p 〈 0.001) was significantly higher than that in the treatment success group. Independent risk factors for all-cause mortality in the LTFU group were age 〉 55 years, fluoroquinolone resistance, cancer and no retreatment. In the LTFU patients who did not receive retreatment, the risk of non-TB-related mortality (aHR 5.00, 95% CI 1.53–16.37, p=0.008) and consequent all-cause mortality (aHR 2.18, 95% CI 1.08–4.40, p=0.030) was significantly higher than that of patients who received retreatment. Conclusion Non-TB-related mortality was the main cause of death and might be reduced by retreatment in LTFU patients with MDR/RR-TB.
Type of Medium:
Online Resource
ISSN:
2312-0541
DOI:
10.1183/23120541.00135-2023
DOI:
10.1183/23120541.00135-2023.Supp1
Language:
English
Publisher:
European Respiratory Society (ERS)
Publication Date:
2023
detail.hit.zdb_id:
2827830-6
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