In:
Биомедицинска истраживања, Univerzitet u Istočnom Sarajevu, Medicinski fakultet Foča, Vol. 1, No. 1 ( 2010-12-28), p. 5-12
Abstract:
& lt;p & gt; & lt;strong & gt;Introduction. & lt;/strong & gt; Extramural venous invasion (EMVI) is a significant predictive factor of the prognosis for patients with colorectal carcinoma and it is directly connected with the relapse of a disease, especially with the appearance of distant metastases. & lt;strong & gt;Methods. & lt;/strong & gt; The research comprises 90 patients with colorectal cancer. Representative samples of tumor tissues obtained by surgical resection are fixed in 4% formalin and embedded into paraffin blocks. Semi-series incisions of 4 & amp;mu;m thickness were stained by HE method and Van Gieson & amp;rsquo;s method. & lt;strong & gt;Results. & lt;/strong & gt;Out of 90 analyzed patients, 21 (23,33%) were with EMVI, and 69 (76.67%) without EMVI on the histological preparations stained by HE method. EMVI was found in 7 more tumors on the preparations stained by Van Gieson & amp;rsquo;s method. Sensitivity of the method determining EMVI on the histological preparations stained by Van Gieson & amp;rsquo;s method was better for 25% (7/28) than on the preparations stained by HE method. EMVI was not found in patients at A and B1 stage of disease according to Astler- Coller classification, but out of 77 patients which were at B2, C1 and C2 stage EMVI was found in 28 (36,36%) patients, p & amp;le;0,01. EMVI was found in 18/77 (23,38%) patients who had a tumor of low histological gradus, p & amp;le;0,01 and in 10/13 (76,92%) patients who had a tumor of high histological gradus, p & amp;le;0,01. In patients with neural invasion, EMVI was found in 18/22 (81,82%), whereas in patients without neural invasion EMVI was found in 10/68 (14,71%), p & amp;le;0,01. In patients with weak intensity of peritumoral lymphocytic reaction EMVI was found in 20/41 (48,78%) whereas in patients with moderate and noticeable level it was found in 8/49 (16,33%), p & amp;le;0,01. There was a significant correlation between extramural venous invasion and other parameters of unfavorable prognosis. & lt;strong & gt;Conclusion. & lt;/strong & gt; EMVI is an important indicator in administration of postoperative adjuvant therapy in patients with colorectal carcinoma. A special histochemical method of elastic fiber stain should be applied in everyday practice when EMVI is not found on HE stained preparations in patients with CRC. & lt;/p & gt;
Type of Medium:
Online Resource
ISSN:
1986-8537
,
1986-8529
DOI:
10.59137/BII202001312C
Language:
English
Publisher:
Univerzitet u Istočnom Sarajevu, Medicinski fakultet Foča
Publication Date:
2010
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