In:
International Journal of Cancer, Wiley, Vol. 134, No. 11 ( 2014-06), p. 2595-2604
Kurzfassung:
What's new? Noxin was previously identified in mice as a stress‐induced gene that may be an important component of the defense machinery of stressed cells. Here, the authors identified human Noxin as a novel cancer‐specific gene whose expression is cell cycle‐regulated and induced by ultraviolet radiation. Knockdown of hNoxin induced apoptosis of A549 cancer cells via p38 MAPK/p53 signaling. Overexpression of hNoxin suppressed DNA damage‐induced apoptosis. These data suggest that hNoxin has anti‐apoptotic activity that protects cancer cells against DNA damage. Knockdown of hNoxin reduced tumor growth in a mouse xenograft model, suggesting that hNoxin is a potential therapeutic target in cancer.
Materialart:
Online-Ressource
ISSN:
0020-7136
,
1097-0215
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2014
ZDB Id:
218257-9
ZDB Id:
1474822-8
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