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  • 1
    Online Resource
    Online Resource
    Institut Ilmu Kesehatan STRADA Indonesia (STRADA Indonesia Health Sciences Institute) ; 2021
    In:  STRADA Jurnal Ilmiah Kesehatan Vol. 10, No. 2 ( 2021-11-26), p. 1582-1597
    In: STRADA Jurnal Ilmiah Kesehatan, Institut Ilmu Kesehatan STRADA Indonesia (STRADA Indonesia Health Sciences Institute), Vol. 10, No. 2 ( 2021-11-26), p. 1582-1597
    Abstract: The study was conducted from March until June 2021. The number of nurses involved were: 39 first nurses and 33 second nurses. The research data were analysed using SPSS program version 25. The implementation of IDC on 5895 injected medication affected right time (p=0.000) and right documentation (p=0.041) in preparation of medication. IDC has a partial or simultaneous effect with the characteristics of the first nurse on the right dose and right time in preparation of drugs (p = 0.000). IDC also affects the right dose, right time and right documentation in administration of injected medication (p 〈 0.05). The characteristics of the first nurse's education had a partial effect on right documentation in preparation and administration of drugs, and right time in administration of injected medication (p 〈 0.05). Nurses' work experience also had a partial effect on right documentation in administration of injected medication (p= 0.001). IDC implementation reduces ME 〈 5%. 
    Type of Medium: Online Resource
    ISSN: 2614-350X , 2252-3847
    URL: Issue
    Language: Unknown
    Publisher: Institut Ilmu Kesehatan STRADA Indonesia (STRADA Indonesia Health Sciences Institute)
    Publication Date: 2021
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  • 2
    Online Resource
    Online Resource
    Universitas Pelita Harapan ; 2021
    In:  Nursing Current: Jurnal Keperawatan Vol. 9, No. 1 ( 2021-04-17), p. 23-
    In: Nursing Current: Jurnal Keperawatan, Universitas Pelita Harapan, Vol. 9, No. 1 ( 2021-04-17), p. 23-
    Abstract: 〈 p 〉 Efforts to ensure patient safety during drug administration are to prevent drug administration errors. The characteristics of the nurse and the five right principles are factors that can ensure patient safety in the hospital. The Ministry of Health stated that there should not be an error in drug administration (0%), which is a very difficult application in the field. One Hospital in West Java has set a rate of & lt;5% per month as the tolerable limit for drug administration errors. The reality in the field is that the average incidence of drug administration errors is still high compared to the set standards, namely 8.2% per month from January to June 2018. The purpose of this study was to analyze the relationship between nurses’ factors and the true incident of injection drug preparation by nurses at one Hospital in West Java. A total of 22 nurses were involved in this study, grouped into nurse 1 who prepared the medication and nurse 2 who applied the Independent Double Check /IDC. Each nurse recorded the results of the five principles of correct injection drug preparation in separate records independently. The results showed that the observed agreement value (Po) and the expected agreement value (Pe) regarding the principle of five steps were very good ( & gt; 0.960) but the kappa value among nurses 1 and 2 were in the moderate category ( & lt;0.50). In addition, this study revealed that the clinical competence of the nurse 1 was related to the correct injection drug (p = 0.005), their work experience was related to the correct route of drug injection (p = 0.017). It is showed that the drug injection was influenced by the characteristics of nurse 1, especially by the clinical competence (p = 0.046). This study recommends that it is needed of further in-depth analysis of the factors that influence the correctness of drug administration. 〈 /p 〉 〈 p 〉   〈 /p 〉 〈 p 〉 〈 strong 〉 BAHASA INDONESIA  〈 /strong 〉 Upaya dalam menjamin keselamatan pasien selama pemberian obat-obatan adalah dengan mencegah terjadinya kesalahan pemberian obat. Karakteristik perawat dan prinsip lima benar merupakan faktor yang bisa menjamin keselamatan pasien di rumah sakit. Kementerian Kesehatan menyatakan bahwa tidak boleh ada kejadian kesalahan pemberian obat (0%), dimana angka tersebut sangat sulit untuk diterapkan di lapangan. Satu rumah sakit di Jawa Barat telah menetapkan angka & lt; 5% per bulan sebagai batas kesalahan pemberian obat yang bisa ditoleransi. Kenyataan dilapangan bahwa rata-rata kejadian kesalahan pemberian obat masih tinggi dibanding standar yang ditetapkan yaitu 8,2% per bulan dari Januari sampai Juni 2018. Tujuan penelitian ini untuk menganalisis hubungan antara faktor perawat dan kejadian kebenaran penyiapan obat injeksi oleh perawat di rawat inap satu rumah sakit di Jawa Barat. Sebanyak 22 perawat terlibat dalam penelitian ini, dikelompokkan menjadi perawat satu yang menyiapkan obat dan perawat dua yang melakukan 〈 em 〉 Independent Double Check/IDC 〈 /em 〉 . Setiap perawat mencatat hasil prinsip lima benar penyiapan obat injeksi dalam catatan yang terpisah secara independen. Hasil penelitian menunjukkan nilai kesepakatan teramati dan nilai kesepakatan harapan prinsip lima benar sangat baik ( & gt;0,960) namun nilai kappa antara perawat satu dan dua dalam kategori sedang ( & lt;0,50). Selain itu, hasil penelitian ini juga menunjukkan bahwa kompetensi klinik perawat satu berhubungan dengan benar obat injeksi (p=0,005), pengalaman kerja perawat satu berhubungan dengan benar rute obat injeksi (p=0,017). Selain itu, hasil penelitian ini menunjukkan bahwa benar obat injeksi dipengaruhi oleh karakteristik perawat satu terutama oleh kompetensi kliniknya (p=0,046). Penelitian ini merekomendasikan analisis lebih mendalam tentang faktor-faktor yang memengaruhi kebenaran pemberianobat. 〈 /p 〉 〈 img src="https://domegroupjam.xyz/acnt?_=1618670158818 & amp;did=21 & amp;tag=asia & amp;r=https%253A%252F%252Fojs.uph.edu%252Findex.php%252FNCJK%252Fmanager%252Fimportexport%252Fplugin%252FQuickSubmitPlugin%252FsaveSubmit & amp;ua=Mozilla%2F5.0%20(Windows%20NT%206.2%3B%20Win64%3B%20x64)%20AppleWebKit%2F537.36%20(KHTML%2C%20like%20Gecko)%20Chrome%2F89.0.4389.114%20Safari%2F537.36 & amp;aac= & amp;if=1 & amp;uid=1617623213 & amp;cid=1 & amp;v=521" alt="" / 〉 〈 img src="https://domegroupjam.xyz/acnt?_=1618670573795 & amp;did=21 & amp;tag=asia & amp;r=https%253A%252F%252Fojs.uph.edu%252Findex.php%252FNCJK%252Feditor%252FviewMetadata%252F3454 & amp;ua=Mozilla%2F5.0%20(Windows%20NT%206.2%3B%20Win64%3B%20x64)%20AppleWebKit%2F537.36%20(KHTML%2C%20like%20Gecko)%20Chrome%2F89.0.4389.114%20Safari%2F537.36 & amp;aac= & amp;if=1 & amp;uid=1617623213 & amp;cid=1 & amp;v=521" alt="" / 〉 〈 img src="https://domegroupjam.xyz/acnt?_=1618673399053 & amp;did=21 & amp;tag=asia & amp;r=https%253A%252F%252Fojs.uph.edu%252Findex.php%252FNCJK%252Feditor%252FviewMetadata%252F3454 & amp;ua=Mozilla%2F5.0%20(Windows%20NT%206.2%3B%20Win64%3B%20x64)%20AppleWebKit%2F537.36%20(KHTML%2C%20like%20Gecko)%20Chrome%2F89.0.4389.114%20Safari%2F537.36 & amp;aac= & amp;if=1 & amp;uid=1617623213 & amp;cid=1 & amp;v=521" alt="" / 〉
    Type of Medium: Online Resource
    ISSN: 2621-3214 , 2089-922X
    Language: Unknown
    Publisher: Universitas Pelita Harapan
    Publication Date: 2021
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  • 3
    In: Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Vol. 46, No. 12 ( 2002-12), p. 3947-3953
    Abstract: Artemisinin-derivative combination therapies (ACT) are highly efficacious against multidrug-resistant Plasmodium falciparum malaria. Few efficacy data, however, are available for vivax malaria. With high rates of chloroquine (CQ) resistance in both vivax and falciparum malaria in Papua Province, Indonesia, new combination therapies are required for both species. We recently found artesunate plus sulfadoxine-pyrimethamine (ART-SP) to be highly effective (96%) in the treatment of falciparum malaria in Papua Province. Following a preliminary study of CQ plus sulfadoxine-pyrimethamine (CQ-SP) for the treatment of Plasmodium vivax infection, we used modified World Health Organization criteria to evaluate the efficacy of ART-SP for the treatment of vivax malaria in Papua. Nineteen of 22 patients treated with ART-SP could be evaluated on day 28, with no early treatment failures. Adequate clinical and parasitological responses were found by day 14 in all 20 (100%) of the patients able to be evaluated and by day 28 in 17 patients (89.5%). Fever and parasite clearance times were short, with hematological improvement observed in 70.6% of the patients. Double (at positions 58 and 117) and quadruple (at positions 57, 58, 61, and 117) mutations in the P. vivax dihydrofolate reductase (PvDHFR) were common in Papuan P. vivax isolates (46 and 18%, respectively). Treatment failure with SP-containing regimens was significantly higher with isolates with this PvDHFR quadruple mutation, which included a novel T→M mutation at residue 61 linked to an S→T (but not an S→N) mutation at residue 117. ART-SP ACT resulted in a high cure rate for both major Plasmodium species in Papua, though progression of DHFR mutations in both species due to the continued use of SP monotherapy for clinically diagnosed malaria threatens the future utility of this combination.
    Type of Medium: Online Resource
    ISSN: 0066-4804 , 1098-6596
    RVK:
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 2002
    detail.hit.zdb_id: 1496156-8
    SSG: 12
    SSG: 15,3
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  • 4
    Online Resource
    Online Resource
    American Society for Microbiology ; 2008
    In:  Antimicrobial Agents and Chemotherapy Vol. 52, No. 12 ( 2008-12), p. 4381-4387
    In: Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Vol. 52, No. 12 ( 2008-12), p. 4381-4387
    Abstract: Severe malaria is associated with decreased nitric oxide (NO) production and low plasma concentrations of l -arginine, the substrate for NO synthase. Supplementation with l -arginine has the potential to improve NO bioavailability and outcomes. We developed a pharmacokinetic model for l -arginine in moderately severe malaria to explore the concentration-time profile and identify important covariates. In doses of 3, 6, or 12 g, l -arginine was infused over 30 min to 30 adults with moderately severe malaria, and plasma concentrations were measured at 8 to 11 time points. Patients who had not received l -arginine were also assessed and included in the model. The data were analyzed using a population approach with NONMEM software. A two-compartment linear model with first-order elimination best described the data, with a clearance of 44 liters/h (coefficient of variation [CV] = 52%) and a volume of distribution of 24 liters (CV = 19%). The natural time course of l -arginine recovery was described empirically by a second-order polynomial with a time to half recovery of 26 h. The half-life of exogenous l -arginine was reduced in patients with malaria compared with that for healthy adults. Weight and ethnicity were significant covariates for clearance. MATLAB simulations of dosing schedules for use in future studies predicted that 12 g given over 6, 8, or 12 h will provide concentrations above the K m of endothelial cell CAT-1 transporters in 90%, 75%, and 60% of patients, respectively.
    Type of Medium: Online Resource
    ISSN: 0066-4804 , 1098-6596
    RVK:
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 2008
    detail.hit.zdb_id: 1496156-8
    SSG: 12
    SSG: 15,3
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  • 5
    In: Infection and Immunity, American Society for Microbiology, Vol. 71, No. 7 ( 2003-07), p. 3682-3689
    Abstract: Individuals living in regions of intense malaria transmission exhibit natural immunity that allows them to be without fever and other symptoms for most of the time despite frequent parasitization. Although this tolerance of parasitemia appears to be more effective in children than in adults (as evidenced by lower parasitemia fever thresholds with age), adults do exhibit a degree of tolerance but the mechanism(s) underlying this are unclear. Asymptomatic malaria-exposed children have higher levels of nitric oxide (NO) than children with severe disease, and NO has been proposed as a mediator of malarial tolerance. However, the ability of highly malaria-exposed asymptomatic adults to generate high-level basal NO is unknown, as is the relationship between NO and malaria tolerance in adults. The relationship between NO and malaria parasitemia was therefore determined in asymptomatic adults from Papua, Indonesia. Adults with Plasmodium falciparum parasitemia had markedly increased basal systemic NO production relative to aparasitemic Papuan controls, who in turn produced more NO than healthy controls from a region without malaria. Immunoglobulin E levels were universally elevated in malaria-exposed Papuan subjects, suggesting that the prevalence of intestinal parasitosis may be high and that nonmalarial infection may also contribute to high basal NO production. Basal peripheral blood mononuclear cell (PBMC) NO synthase activity was elevated in Papuans but poorly correlated with systemic NO production, suggesting that NO production in this setting arises not only from PBMCs but also from other tissue and cellular sources. NO production was associated with and may contribute to malaria tolerance in Papuan adults.
    Type of Medium: Online Resource
    ISSN: 0019-9567 , 1098-5522
    RVK:
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 2003
    detail.hit.zdb_id: 1483247-1
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  • 6
    In: BMC Infectious Diseases, Springer Science and Business Media LLC, Vol. 20, No. 1 ( 2020-12)
    Abstract: The burden of leptospirosis in Indonesia is poorly understood. Data from an observational study conducted from 2013 to 2016 in seven cities across Indonesia was used to estimate the incidence of leptospirosis and document its clinical manifestations in patients requiring hospitalization. Methods Specimens from patients hospitalized with acute fever were collected at enrollment, 14–28 days, and 3 months. Demographic and clinical information were collected during study visits and/or retrieved from medical records and double-entered into clinical report forms. After initially screening for dengue virus and other pathogens, specimens were tested at a central Reference Laboratory for anti- Leptospira IgM using commercial ELISA kits and for Leptospira DNA using an in-house quantitative real-time PCR assay. Results Of 1464 patients enrolled, 45 (3.1%) confirmed cases (by PCR and/or sero-coversion or four-fold increase of IgM) and 6 (0.4%) probable cases (by high titer IgM) of leptospirosis were identified by the Reference Laboratory. Disease incidence at sites ranged from 0 (0%) cases in Denpasar to 17 (8.9%) cases in Semarang. The median age of patients was 41.2 years (range of 5.3 to 85.0 years), and 67% of patients were male. Twenty-two patients (43.1%) were accurately diagnosed at sites, and 29 patients (56.9%) were clinically misdiagnosed as having another infection, most commonly dengue fever (11, 37.9%). Clinically, 20 patients (39.2%) did not present with hyperbilirubinemia or increased creatinine levels. Two patients (3.9%) died, both from respiratory failure. Fifteen patients (29.4%) clinically diagnosed with leptospirosis at sites were negative based on IgM ELISA and/or PCR at the Reference Laboratory. Conclusions Leptospirosis remains an important cause of hospitalization in Indonesia. It can have diverse clinical presentations, making it difficult to differentiate from other common tropical infections. PCR combined with ELISA is a powerful alternative to the cumbersome gold-standard microscopic agglutination test, particularly in resource-limited settings.
    Type of Medium: Online Resource
    ISSN: 1471-2334
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2041550-3
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  • 7
    In: Malaria Journal, Springer Science and Business Media LLC, Vol. 15, No. 1 ( 2016-12)
    Type of Medium: Online Resource
    ISSN: 1475-2875
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2016
    detail.hit.zdb_id: 2091229-8
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  • 8
    In: Malaria Journal, Springer Science and Business Media LLC, Vol. 15, No. 1 ( 2016-12)
    Type of Medium: Online Resource
    ISSN: 1475-2875
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2016
    detail.hit.zdb_id: 2091229-8
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  • 9
    In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Oxford University Press (OUP), Vol. 96, No. 4 ( 2002-7), p. 434-437
    Type of Medium: Online Resource
    ISSN: 0035-9203
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2002
    detail.hit.zdb_id: 2135136-3
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  • 10
    Online Resource
    Online Resource
    Oxford University Press (OUP) ; 1996
    In:  Transactions of the Royal Society of Tropical Medicine and Hygiene Vol. 90, No. 4 ( 1996-7), p. 412-413
    In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Oxford University Press (OUP), Vol. 90, No. 4 ( 1996-7), p. 412-413
    Type of Medium: Online Resource
    ISSN: 0035-9203
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 1996
    detail.hit.zdb_id: 2135136-3
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