In:
PLOS Pathogens, Public Library of Science (PLoS), Vol. 18, No. 11 ( 2022-11-2), p. e1010915-
Kurzfassung:
The clinical presentation of MIS-C overlaps with other infectious/non-infectious diseases such as acute COVID-19, Kawasaki disease, acute dengue, enteric fever, and systemic lupus erythematosus. We examined the ex-vivo cellular parameters with the aim of distinguishing MIS-C from other syndromes with overlapping clinical presentations. MIS-C children differed from children with non-MIS-C conditions by having increased numbers of naïve CD8 + T cells, naïve, immature and atypical memory B cells and diminished numbers of transitional memory, stem cell memory, central and effector memory CD4 + and CD8 + T cells, classical, activated memory B and plasma cells and monocyte (intermediate and non-classical) and dendritic cell (plasmacytoid and myeloid) subsets. All of the above alterations were significantly reversed at 6–9 months post-recovery in MIS-C. Thus, MIS-C is characterized by a distinct cellular signature that distinguishes it from other syndromes with overlapping clinical presentations. Trial Registration: ClinicalTrials.gov clinicaltrial.gov. No: NCT04844242 .
Materialart:
Online-Ressource
ISSN:
1553-7374
DOI:
10.1371/journal.ppat.1010915
DOI:
10.1371/journal.ppat.1010915.g001
DOI:
10.1371/journal.ppat.1010915.g002
DOI:
10.1371/journal.ppat.1010915.g003
DOI:
10.1371/journal.ppat.1010915.g004
DOI:
10.1371/journal.ppat.1010915.g005
DOI:
10.1371/journal.ppat.1010915.g006
DOI:
10.1371/journal.ppat.1010915.t001
DOI:
10.1371/journal.ppat.1010915.s001
DOI:
10.1371/journal.ppat.1010915.s002
DOI:
10.1371/journal.ppat.1010915.s003
DOI:
10.1371/journal.ppat.1010915.s004
DOI:
10.1371/journal.ppat.1010915.s005
DOI:
10.1371/journal.ppat.1010915.s006
DOI:
10.1371/journal.ppat.1010915.s007
DOI:
10.1371/journal.ppat.1010915.s008
Sprache:
Englisch
Verlag:
Public Library of Science (PLoS)
Publikationsdatum:
2022
ZDB Id:
2205412-1
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