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  • 1
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    The surgical safety checklist and patient outcomes after surgery: a prospective observational cohort study, systematic review and meta-analysis
    Elsevier BV ; 2018
    In:  British Journal of Anaesthesia Vol. 120, No. 1 ( 2018-01), p. 146-155
    Details
    In: British Journal of Anaesthesia, Elsevier BV, Vol. 120, No. 1 ( 2018-01), p. 146-155
    Materialart: Online-Ressource
    ISSN: 0007-0912
    URL: Article
    DOI: 10.1016/j.bja.2017.08.002
    Sprache: Englisch
    Verlag: Elsevier BV
    Publikationsdatum: 2018
    ZDB Id: 2011968-9
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  • 2
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    Prospective observational cohort study on grading the severity of postoperative complications in global surgery research
    Oxford University Press (OUP) ; 2019
    In:  British Journal of Surgery Vol. 106, No. 2 ( 2019-01-08), p. e73-e80
    Details
    In: British Journal of Surgery, Oxford University Press (OUP), Vol. 106, No. 2 ( 2019-01-08), p. e73-e80
    Kurzfassung: The Clavien–Dindo classification is perhaps the most widely used approach for reporting postoperative complications in clinical trials. This system classifies complication severity by the treatment provided. However, it is unclear whether the Clavien–Dindo system can be used internationally in studies across differing healthcare systems in high- (HICs) and low- and middle-income countries (LMICs). Methods This was a secondary analysis of the International Surgical Outcomes Study (ISOS), a prospective observational cohort study of elective surgery in adults. Data collection occurred over a 7-day period. Severity of complications was graded using Clavien–Dindo and the simpler ISOS grading (mild, moderate or severe, based on guided investigator judgement). Severity grading was compared using the intraclass correlation coefficient (ICC). Data are presented as frequencies and ICC values (with 95 per cent c.i.). The analysis was stratified by income status of the country, comparing HICs with LMICs. Results A total of 44 814 patients were recruited from 474 hospitals in 27 countries (19 HICs and 8 LMICs). Some 7508 patients (16·8 per cent) experienced at least one postoperative complication, equivalent to 11 664 complications in total. Using the ISOS classification, 5504 of 11 664 complications (47·2 per cent) were graded as mild, 4244 (36·4 per cent) as moderate and 1916 (16·4 per cent) as severe. Using Clavien–Dindo, 6781 of 11 664 complications (58·1 per cent) were graded as I or II, 1740 (14·9 per cent) as III, 2408 (20·6 per cent) as IV and 735 (6·3 per cent) as V. Agreement between classification systems was poor overall (ICC 0·41, 95 per cent c.i. 0·20 to 0·55), and in LMICs (ICC 0·23, 0·05 to 0·38) and HICs (ICC 0·46, 0·25 to 0·59). Conclusion Caution is recommended when using a treatment approach to grade complications in global surgery studies, as this may introduce bias unintentionally.
    Materialart: Online-Ressource
    ISSN: 0007-1323 , 1365-2168
    URL: Article
    DOI: 10.1002/bjs.11025
    Sprache: Englisch
    Verlag: Oxford University Press (OUP)
    Publikationsdatum: 2019
    ZDB Id: 2006309-X
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  • 3
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    Prediction of postoperative infection in elderly using deep learning-based analysis: an observational cohort study
    Springer Science and Business Media LLC ; 2023
    In:  Aging Clinical and Experimental Research Vol. 35, No. 3 ( 2023-01-04), p. 639-647
    Details
    In: Aging Clinical and Experimental Research, Springer Science and Business Media LLC, Vol. 35, No. 3 ( 2023-01-04), p. 639-647
    Kurzfassung: Elderly patients are susceptible to postoperative infections with increased mortality. Analyzing with a deep learning model, the perioperative factors that could predict and/or contribute to postoperative infections may improve the outcome in elderly. This was an observational cohort study with 2014 elderly patients who had elective surgery from 28 hospitals in China from April to June 2014. We aimed to develop and validate deep learning-based predictive models for postoperative infections in the elderly. 1510 patients were randomly assigned to be training dataset for establishing deep learning-based models, and 504 patients were used to validate the effectiveness of these models. The conventional model predicted postoperative infections was 0.728 (95% CI 0.688–0.768) with the sensitivity of 66.2% (95% CI 58.2–73.6) and specificity of 66.8% (95% CI 64.6–68.9). The deep learning model including risk factors relevant to baseline clinical characteristics predicted postoperative infections was 0.641 (95% CI 0.545–0.737), and sensitivity and specificity were 34.2% (95% CI 19.6–51.4) and 88.8% (95% CI 85.6–91.6), respectively. Including risk factors relevant to baseline variables and surgery, the deep learning model predicted postoperative infections was 0.763 (95% CI 0.681–0.844) with the sensitivity of 63.2% (95% CI 46–78.2) and specificity of 80.5% (95% CI 76.6–84). Our feasibility study indicated that a deep learning model including risk factors for the prediction of postoperative infections can be achieved in elderly. Further study is needed to assess whether this model can be used to guide clinical practice to improve surgical outcomes in elderly.
    Materialart: Online-Ressource
    ISSN: 1720-8319
    URL: Article
    DOI: 10.1007/s40520-022-02325-3
    Sprache: Englisch
    Verlag: Springer Science and Business Media LLC
    Publikationsdatum: 2023
    ZDB Id: 2119282-0
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  • 4
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    New Treatment of Neonatal Pulmonary Hemorrhage with Hemocoagulase in Addition to Mechanical Ventilation
    S. Karger AG ; 2005
    In:  Neonatology Vol. 88, No. 2 ( 2005), p. 118-121
    Details
    In: Neonatology, S. Karger AG, Vol. 88, No. 2 ( 2005), p. 118-121
    Kurzfassung: 〈 i 〉 Objective: 〈 /i 〉 To investigate the effect of a new treatment for neonatal pulmonary hemorrhage with hemocoagulase in addition to mechanical ventilation. 〈 i 〉 Methods: 〈 /i 〉 Forty-eight newborn infants with pulmonary hemorrhage were included and divided randomly into 2 groups. Among them, 28 patients were treated with hemocoagulase in addition to mechanical ventilation, and the other 20 neonates served as controls and were treated with mechanical ventilation only. 〈 i 〉 Results: 〈 /i 〉 Both the length of pulmonary hemorrhage and the duration ofmechanical ventilation in the survivors were significantly shortened in the infants treated with hemocoagulase in addition to mechanical ventilation as compared to controls (p 〈 0.05). Moreover, all infants that were unable to remain in the neonatal intensive care unit died after discharge, and when their outcome was estimated as non-survivors, the mortality in the patients with this new treatment was 39.3% (11/28), which was significantly lower than in controls (75.0%, 15/20; p 〈 0.05). When the discharged infants were not included in the statistics, the mortality in the hemocoagulase group was 10.7% (3/28), which was also significantly lower than in controls (40.0%, 8/20; p 〈 0.05). 〈 i 〉 Conclusions: 〈 /i 〉 The new treatment with hemocoagulase in addition to mechanical ventilation is effective in newborn infants with pulmonary hemorrhage.
    Materialart: Online-Ressource
    ISSN: 1661-7800 , 1661-7819
    URL: Article
    DOI: 10.1159/000085826
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2005
    ZDB Id: 2403535-X
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
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    Torque allocation strategy based on economy and stability for electric vehicle considering controllability after motors failure
    SAGE Publications ; 2023
    In:  Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering Vol. 237, No. 12 ( 2023-10), p. 2759-2779
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering, SAGE Publications, Vol. 237, No. 12 ( 2023-10), p. 2759-2779
    Kurzfassung: To reduce the energy consumption and improve the stability of distributed drive electric vehicles, a torque allocation strategy based on an economy and stability optimisation function (ESOF) and a fuzzy proportional-integral-derivative rule control (FPRC) strategy are proposed while considering motor efficiency, braking energy recovery and motor failure. First, the vehicle dynamics and motor equivalent models are established. Subsequently, a torque prediction model and fuzzy controller for the vehicle are designed to calculate the total desired torque and yaw moment, respectively. A torque optimisation function is established to minimise power losses in the electric motor and maximise braking energy recovery, and it is solved using an improved genetic algorithm. While satisfying vehicle driving constraints, the ESOF-based controller can effectively coordinate the operation of each motor in the high-efficiency range under driving and braking conditions. After one motor fault is detected, the ESOF-based controller is replaced with an FPRC-based controller to distribute the vehicle demand torque. A co-simulation platform integrating MATLAB/Simulink and CarSim is developed to verify the effectiveness of the proposed ESOF-based controller in the New European Driving Cycle (NEDC) and Federal Test Procedure 75 (FTP75) driving cycles. The effectiveness of the FPRC-based controller in step steering condition is verified using the co-simulation platform. The simulation results indicate that the vehicle economy and driving range of the ESOF-based controller improved compared with the results afforded by the typical torque distribution strategy based on the front–rear axle dynamic load ratio. The average efficiencies of the motors in the NEDC and FTP75 driving cycles increased by 2.94% and 2.4%, respectively. More importantly, the FPRC-based controller can more significantly improve the steering stability of a vehicle with motor failure compared with the ESOF-based controller.
    Materialart: Online-Ressource
    ISSN: 0954-4070 , 2041-2991
    URL: Article
    DOI: 10.1177/09544070221121838
    RVK:
    ZO 4200
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2023
    ZDB Id: 2032754-7
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  • 6
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    Vasorin Deletion in C57BL/6J Mice Induces Hepatocyte Autophagy through Glycogen-Mediated mTOR Regulation
    MDPI AG ; 2022
    In:  Nutrients Vol. 14, No. 17 ( 2022-08-31), p. 3600-
    Details
    In: Nutrients, MDPI AG, Vol. 14, No. 17 ( 2022-08-31), p. 3600-
    Kurzfassung: Abnormal vasorin (Vasn) expression occurs in multiple diseases, particularly liver cancers. Vasn knockout (KO) in mice causes malnutrition, a shortened life span, and decreased physiological functions. However, the causes and underlying mechanisms remain unknown. Here, we established Vasn KO C57BL/6J mice by using the CRISPR/Cas9 system. The animals were weighed, and histology, immunohistochemistry, electronic microscopy, and liver function tests were used to examine any change in the livers. Autophagy markers were detected by Western blotting. MicroRNA (miRNA) sequencing was performed on liver samples and analyses to study the signaling pathway altered by Vasn KO. Significant reductions in mice body and liver weight, accompanied by abnormal liver function, liver injury, and reduced glycogen accumulation in hepatocytes, were observed in the Vasn KO mice. The deficiency of Vasn also significantly increased the number of autophagosomes and the expression of LC3A/B-II/I but decreased SQSTM1/p62 levels in hepatocytes, suggesting aberrant activation of autophagy. Vasn deficiency inhibited glycogen-mediated mammalian target of rapamycin (mTOR) phosphorylation and activated Unc-51-like kinase 1 (ULK1) signaling, suggesting that Vasn deletion upregulates hepatocyte autophagy through the mTOR-ULK1 signaling pathway as a possible cause of diminished life span and health. Our results indicate that Vasn is required for the homeostasis of liver glycogen metabolism upstream of hepatocyte autophagy, suggesting research values for regulating Vasn in pathways related to liver physiology and functions. Overall, this study provides new insight into the role of Vasn in liver functionality.
    Materialart: Online-Ressource
    ISSN: 2072-6643
    URL: Article
    DOI: 10.3390/nu14173600
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2022
    ZDB Id: 2518386-2
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  • 7
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    Concurrent chronic neutrophilic leukemia blast crisis and multiple myeloma: A case report and literature review
    Spandidos Publications ; 2015
    In:  Oncology Letters Vol. 9, No. 5 ( 2015), p. 2208-2210
    Details
    In: Oncology Letters, Spandidos Publications, Vol. 9, No. 5 ( 2015), p. 2208-2210
    Materialart: Online-Ressource
    ISSN: 1792-1074 , 1792-1082
    URL: Article
    DOI: 10.3892/ol.2015.3043
    Sprache: Englisch
    Verlag: Spandidos Publications
    Publikationsdatum: 2015
    ZDB Id: 2573196-8
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  • 8
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    Transcriptome sequencing analysis for the identification of stable lncRNAs associated with bovine Staphylococcus aureus mastitis
    Springer Science and Business Media LLC ; 2021
    In:  Journal of Animal Science and Biotechnology Vol. 12, No. 1 ( 2021-12)
    Details
    In: Journal of Animal Science and Biotechnology, Springer Science and Business Media LLC, Vol. 12, No. 1 ( 2021-12)
    Kurzfassung: Staphylococcus aureus ( S. aureus ) mastitis is one of the most difficult diseases to treat in lactating dairy cows worldwide. S. aureus with different lineages leads to different host immune responses. Long non-coding RNAs (lncRNAs) are reported to be widely involved in the progress of inflammation. However, no research has identified stable lncRNAs among different S. aureus strain infections. In addition, folic acid (FA) can effectively reduce inflammation, and whether the inflammatory response caused by S. aureus can be reduced by FA remains to be explored. Methods lncRNA transcripts were identified from Holstein mammary gland tissues infected with different concentrations of S. aureus ( in vivo ) and mammary alveolar cells (Mac-T cells, in vitro ) challenged with different S. aureus strains. Differentially expressed (DE) lncRNAs were evaluated, and stable DE lncRNAs were identified in vivo and in vitro . On the basis of the gene sequence conservation and function conservation across species, key lncRNAs with the function of potentially immune regulation were retained for further analysis. The function of FA on inflammation induced by S. aureus challenge was also investigated. Then, the association analysis between these keys lncRNA transcripts and hematological parameters (HPs) was carried out. Lastly, the knockdown and overexpression of the important lncRNA were performed to validate the gene function on the regulation of cell immune response. Results Linear regression analysis showed a significant correlation between the expression levels of lncRNA shared by mammary tissue and Mac-T cells ( P   〈  0.001, R 2  = 0.3517). lncRNAs PRANCR and TNK2–AS1 could be regarded as stable markers associated with bovine S. aureus mastitis. Several HPs could be influenced by SNPs around lncRNAs PRANCR and TNK2–AS1 . The results of gene function validation showed PRANCR regulates the mRNA expression of SELPLG and ITGB2 within the S. aureus infection pathway and the Mac-T cells apoptosis. In addition, FA regulated the expression change of DE lncRNA involved in toxin metabolism and inflammation to fight against S. aureus infection. Conclusions The remarkable association between SNPs around these two lncRNAs and partial HP indicates the potentially important role of PRANCR and TNK2–AS1 in immune regulation. Stable DE lncRNAs PRANCR and TNK2–AS1 can be regarded as potential targets for the prevention of bovine S. aureus mastitis. FA supplementation can reduce the negative effect of S. aureus challenge by regulating the expression of lncRNAs.
    Materialart: Online-Ressource
    ISSN: 2049-1891
    URL: Article
    DOI: 10.1186/s40104-021-00639-2
    Sprache: Englisch
    Verlag: Springer Science and Business Media LLC
    Publikationsdatum: 2021
    ZDB Id: 2630162-3
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  • 9
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    Nasal intermittent positive pressure ventilation versus nasal continuous positive airway pressure for preterm infants with respiratory distress syndrome: A meta‐analysis and up‐date
    Wiley ; 2015
    In:  Pediatric Pulmonology Vol. 50, No. 4 ( 2015-04), p. 402-409
    Details
    In: Pediatric Pulmonology, Wiley, Vol. 50, No. 4 ( 2015-04), p. 402-409
    Kurzfassung: To evaluate whether nasal intermittent positive pressure ventilation (NIPPV) would decrease the requirement for endotracheal ventilation compared with nasal continuous positive airway pressure(NCPAP) for preterm infants with respiratory distress syndrome (RDS) and compare the related complications between these two noninvasive variations of respiratory support Methods A search of major electronic databases, including Medline (1980–2013) and the Cochrane Central Register of Controlled Trials, for randomized controlled trials that compared NIPPV versus NCPAP for preterm infants with RDS was performed. Main Results Six randomized controlled trials met selection criteria (n = 1,527). The meta‐analyses demonstrated significant decrease in the need for invasive ventilation in the NIPPV group (RR:0.53; 95% CI, 0.33–0.85). In the subgroup of infants who received surfactant also demonstrated a significant rate of failure of nasal support in the NIPPV group (RR:0.57; 95% CI 0.42–0.78). However, the subgroup of infants whose gestational age (GA) ≤ 30 weeks or birth weight (BW)  〈  1,500 g showed no difference between the two groups (RR:0.59; 95% CI 0.27–1.26); and the subgroup of infants whose GA  〉  30 weeks or BW  〉  1,500 g also showed no difference between the two groups (RR:0.63; 95% CI 0.29–1.39). No differences in other outcome variables were observed between the two groups. Conclusions Among preterm infants with RDS, there was a significant decrease in the need for invasive ventilation in the NIPPV group as compared with NCPAP group, especially for the infants who received surfactant. However, NIPPV could not decrease the need for invasive ventilation both in the subgroup of infants whose GA ≤ 30 weeks or BW  〈  1,500 g and the subgroup of infants with BW of 〉 30 weeks or BW  〉  1,500 g. It is limited to analysis the primary outcome generally. Larger trials of this intervention are needed to assess the difference in this primary outcome and the related complications between both forms of noninvasive respiratory support. Pediatr Pulmonol. 2015; 50:402–409. © 2014 Wiley Periodicals, Inc.
    Materialart: Online-Ressource
    ISSN: 8755-6863 , 1099-0496
    URL: Issue
    URL: Article
    DOI: 10.1002/ppul.v50.4
    DOI: 10.1002/ppul.23130
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2015
    ZDB Id: 1491904-7
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  • 10
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    The Significance of Inflammatory Markers in the Prognosis of Newly Diagnosed Multiple Myeloma Patients
    Science Repository OU ; 2020
    In:  Clinical Oncology and Research
    Details
    In: Clinical Oncology and Research, Science Repository OU
    Kurzfassung: Objective: To explore the significance of the ratio of neutrophils to lymphocytes (NLR), monocytes to lymphocytes (MLR), and platelets to lymphocytes (PLR) in the prognosis of patients with newly diagnosed multiple myeloma. Methods: A total of 60 patients with MM who were diagnosed in Jiangning Hospital Affiliated to Nanjing Medical University and Zhongda Hospital Affiliated to Southeast University from August 2011 to March 2020 were retrospectively analysed. According to NLR, MLR, PLR, the patients were divided into the low NLR group (NLR 〈 3.61) or high NLR group (NLR ≥ 3.61), low MLR group (MLR 〈 0.33) or high MLR group (MLR ≥ 0.33), low PLR group (PLR 〈 129.78) and high PLR group (PLR ≥ 129.78). Overall survival (OS) was used as the prognostic evaluation criteria, and Kaplan-Meier survival curve, Log-rank test and Cox regression model were used to carry out univariate and multivariate analysis on clinical and laboratory parameters. Results: Among the 60 patients, 33 were male and 27 were female, the median age of the patients was 65 years old, 19 were in the high NLR group, 41 were in the low NLR group, 24 were in the high MLR group, 36 were in the low MLR group, 26 were in the high PLR group, and 34 were in the low PLR group. The univariate analysis showed the prognosis was influenced by factors including NLR, PLR, age, ISS stages, hemoglobin (HGB), albumin (ALT). MLR, type of immunoglobulin, white globulin ratio (A/G), gender, β2-microglobulin(β2-MG), lactate dehydrogenase (LDH) and creatinine were not correlated with the total survival time of patients. The multivariate analysis showed that ISS III stages, PLR ≥ 129.78, HGB 〈 100g/L were independent risk factors influencing the prognosis of MM patients. Conclusion: ISS III stages, PLR ≥ 129.78, HGB 〈 100g/L are independent prognostic risk factors in newly diagnosed multiple myeloma patients, which can be used as an economical and effective method for early evaluation of patient prognosis.
    Materialart: Online-Ressource
    ISSN: 2613-4942 , 2613-4942
    URL: Journal
    URL: Article
    DOI: 10.31487/j.COR
    DOI: 10.31487/j.COR.2020.09.01
    Sprache: Unbekannt
    Verlag: Science Repository OU
    Publikationsdatum: 2020
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