In:
Contact Dermatitis, Wiley, Vol. 71, No. 2 ( 2014-08), p. 82-91
Abstract:
Palladium (Pd) and gold (Au) based dental alloys have been associated with oral disease. Objectives This study was designed to explore possible associations between the presence of A u‐based and P d‐based dental alloys, and oral lesions, systemic complaints, and specific in vivo and in vitro immune responses. Methods The investigated population consisted of three groups: 26 non‐metal‐allergic volunteers, 25 metal‐allergic patients, and 20 oral disease patients. Medical histories were taken, oral examinations were carried out, and compositions of all dental alloys were determined. Then, A u and P d patch tests and in vitro assays were performed, revealing cytokine production by peripheral blood mononuclear cells [T helper ( T h)1, interferon‐γ; T h2, interleukin ( IL )‐5 and IL ‐13] and lymphocyte proliferation ( LTT‐MELISA ® ). Results Non‐plaque‐related gingivitis was associated with the presence of P d‐based dental alloys, and P d‐positive patch tests and in vitro assays. Collectively, participants with P d‐based dental alloys showed increased P d patch test reactivity ( p 〈 0.05) and lymphoproliferation ( p 〈 0.05). In contrast, oral lichenoid lesions were associated with A u‐based alloys ( p 〈 0.05), but this was not reflected by A u‐specific immunoreactivity. Conclusions Oral lesions and P d‐induced immune responses are associated with the presence of dental alloys. However, most oral disease patients did not show positive patch test results or in vitro signs of specific immunoreactivity, suggesting local toxic reactions or the involvement of innate immune responses.
Type of Medium:
Online Resource
ISSN:
0105-1873
,
1600-0536
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2027120-7
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