In:
Angewandte Chemie, Wiley, Vol. 127, No. 13 ( 2015-03-23), p. 4118-4122
Abstract:
Recent reports have highlighted the biological activity associated with a subfamily of the tetramic acid class of natural products. Despite the fact that members of this subfamily act as protein–protein interaction inhibitors that are of relevance to proteasome assembly, no synthetic work has been reported. This may be due to the fact that this subfamily contains an unnatural 4,4‐disubstitued glutamic acid, the synthesis of which provides a key challenge. A highly stereoselective route to a masked form of this unnatural amino acid now enabled the synthesis of two of the possible diastereomers of JBIR‐22 and allowed the assignment of its relative and absolute stereochemistry.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v127.13
DOI:
10.1002/ange.201411141
Language:
German
Publisher:
Wiley
Publication Date:
2015
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