In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 11 ( 2021-11-17), p. e0259128-
Abstract:
Breast Cancer Metastasis Suppressor 1 (BRMS1) expression is associated with longer patient survival in multiple cancer types. Understanding BRMS1 functionality will provide insights into both mechanism of action and will enhance potential therapeutic development. In this study, we confirmed that the C-terminus of BRMS1 is critical for metastasis suppression and hypothesized that critical protein interactions in this region would explain its function. Phosphorylation status at S237 regulates BRMS1 protein interactions related to a variety of biological processes, phenotypes [cell cycle (e.g., CDKN2A), DNA repair (e.g., BRCA1)], and metastasis [(e.g., TCF2 and POLE2)] . Presence of S237 also directly decreased MDA-MB-231 breast carcinoma migration in vitro and metastases in vivo . The results add significantly to our understanding of how BRMS1 interactions with Sin3/HDAC complexes regulate metastasis and expand insights into BRMS1’s molecular role, as they demonstrate BRMS1 C-terminus involvement in distinct protein-protein interactions.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0259128
DOI:
10.1371/journal.pone.0259128.g001
DOI:
10.1371/journal.pone.0259128.g002
DOI:
10.1371/journal.pone.0259128.g003
DOI:
10.1371/journal.pone.0259128.g004
DOI:
10.1371/journal.pone.0259128.g005
DOI:
10.1371/journal.pone.0259128.g006
DOI:
10.1371/journal.pone.0259128.g007
DOI:
10.1371/journal.pone.0259128.t001
DOI:
10.1371/journal.pone.0259128.t002
DOI:
10.1371/journal.pone.0259128.s001
DOI:
10.1371/journal.pone.0259128.s002
DOI:
10.1371/journal.pone.0259128.s003
DOI:
10.1371/journal.pone.0259128.s004
DOI:
10.1371/journal.pone.0259128.s005
DOI:
10.1371/journal.pone.0259128.s006
DOI:
10.1371/journal.pone.0259128.s007
DOI:
10.1371/journal.pone.0259128.s008
DOI:
10.1371/journal.pone.0259128.s009
DOI:
10.1371/journal.pone.0259128.s010
DOI:
10.1371/journal.pone.0259128.s011
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
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