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  • 1
    In: Journal of Neural Transmission, Springer Science and Business Media LLC, Vol. 129, No. 11 ( 2022-11), p. 1377-1385
    Abstract: The prevalence of Parkinson’s disease (PD) is rising, rendering it one of the most common neurodegenerative diseases. Treatment and monitoring of patients require regular specialized in- and outpatient care. Patients with PD are more likely to have a complicated disease course if they become infected with severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). Regular in-hospital appointments place these patients at risk of exposure to SARS-CoV-2 due to travel and contact with other patients and staff. However, guidelines for the management of outpatients with PD during times of increased risk of infection are currently lacking. These are urgently needed to conduct risk–benefit evaluations to recommend the best medical treatment. This article discusses best practice approaches based on the current literature, as suggested by the multidisciplinary Network of University Medicine (NUM) in Germany. These include measures such as mask-wearing, hand hygiene, social distancing measures, and appropriate testing strategies in outpatient settings, which can minimize the risk of exposure. Furthermore, the urgency of appointments should be considered. Visits of low urgency may be conducted by general practitioners or via telemedicine consultations, whereas in-person presentation is required in case of moderate and high urgency visits. Classification of urgency should be carried out by skilled medical staff, and telemedicine (telephone or video consultations) may be a useful tool in this situation. The currently approved vaccines against SARS-CoV-2 are safe and effective for patients with PD and play a key role in minimizing infection risk for patients with PD.
    Type of Medium: Online Resource
    ISSN: 0300-9564 , 1435-1463
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 1481655-6
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  • 2
    In: Veterinary Microbiology, Elsevier BV, Vol. 150, No. 1-2 ( 2011-5), p. 191-197
    Type of Medium: Online Resource
    ISSN: 0378-1135
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2011
    detail.hit.zdb_id: 1498996-7
    SSG: 22
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  • 3
    In: Veterinary Microbiology, Elsevier BV, Vol. 153, No. 3-4 ( 2011-12), p. 414-416
    Type of Medium: Online Resource
    ISSN: 0378-1135
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2011
    detail.hit.zdb_id: 1498996-7
    SSG: 22
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  • 4
    Online Resource
    Online Resource
    Cambridge University Press (CUP) ; 2007
    In:  Infection Control & Hospital Epidemiology Vol. 28, No. 4 ( 2007-04), p. 446-452
    In: Infection Control & Hospital Epidemiology, Cambridge University Press (CUP), Vol. 28, No. 4 ( 2007-04), p. 446-452
    Abstract: To determine the appropriate method to calculate the rate of methicillin-resistant Staphylococcus aureus (MRSA) infection and colonization (hereafter, MRSA rates) for interhospital comparisons, such that the large number of patients who are already MRSA positive on admission is taken into account. Design. A prospective, multicenter, hospital-based surveillance of MRSA-positive case patients from January through December 2004. Setting. Data from 31 hospitals participating in the German national nosocomial infections surveillance system (KISS) were recorded during routine surveillance by the infection control team at each hospital. Results. Data for 4,215 MRSA-positive case patients were evaluated. From this data, the following values were calculated. The median incidence density was 0.71 MRSA-positive case patients per 1,000 patient-days, and the median nosocomial incidence density was 0.27 patients with nosocomial MRSA infection or colonization per 1,000 patient-days (95% CI, 0.18-0.34). The median average daily MRSA burden was 1.13 MRSA patient-days per 100 patient-days (95% CI, 0.86-1.51), with the average daily MRSA burden defined as the total number of MRSA patient-days divided by the total number of patient-days times 100. The median MRSA-days–associated nosocomial MRSA infection and colonization rate, which describes the MRSA infection risk for other patients in hospitals housing large numbers of MRSA-positive patients and/or many patients who were MRSA positive on admission, was 23.1 cases of nosocomial MRSA infection and colonization per 1,000 MRSA patient-days (95% CI, 17.4-28.6). The values were also calculated for various MRSA screening levels. Conclusions. The MRSA-days–associated nosocomial MRSA rate allows investigators to assess the extent of MRSA colonization and infection at each hospital, taking into account cases that have been imported from other hospitals, as well as from the community. This information provides an appropriate incentive for hospitals to introduce further infection control measures.
    Type of Medium: Online Resource
    ISSN: 0899-823X , 1559-6834
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2007
    detail.hit.zdb_id: 2106319-9
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  • 5
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2010
    In:  BMC Infectious Diseases Vol. 10, No. 1 ( 2010-12)
    In: BMC Infectious Diseases, Springer Science and Business Media LLC, Vol. 10, No. 1 ( 2010-12)
    Type of Medium: Online Resource
    ISSN: 1471-2334
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2010
    detail.hit.zdb_id: 2041550-3
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  • 6
    In: Antimicrobial Resistance & Infection Control, Springer Science and Business Media LLC, Vol. 10, No. 1 ( 2021-12)
    Abstract: Prevention of surgical site infections (SSIs), which due to their long-term consequences are especially critical in orthopedic surgery, entails compliance with over 20 individual measures. However, little is known about the psychosocial determinants of such compliance among orthopedic physicians, which impedes efforts to tailor implementation interventions to improve compliance. Thus, for this professional group, this pilot survey examined psychosocial determinants of self-reported compliance, which have been theoretically derived from the COM-B (Capability, Opportunity, Motivation and Behavior) model. Methods In 2019, a cross-sectional survey was conducted in a tertiary care university orthopedic clinic in Hannover, Germany, as a pilot for the WACH-trial (“Wundinfektionen und Antibiotikaverbrauch in der Chirurgie” [Wound Infections and Antibiotics Consumption in Surgery]). Fifty-two physicians participated (38 surgeons, 14 anesthesiologists; response rate: 73.2%). The questionnaire assessed self-reported compliance with 26 SSI preventive measures, and its psychosocial determinants (COM-B). Statistical analyses included descriptive, correlational, and linear multiple regression modeling. Results Self-reported compliance rates for individual measures varied from 53.8 to 100%, with overall compliance (defined for every participant as the mean of his or her self-reported rates for each individual measure) averaging at 88.9% (surgeons: 90%, anesthesiologists: 85.9%; p  = 0.097). Of the components identified in factor analyses of the COM-B items, planning, i.e., self-formulated conditional plans to comply, was the least pronounced (mean = 4.3 on the 7-point Likert scale), while motivation was reported to be the strongest (mean = 6.3). Bi-variately, the overall compliance index co-varied with all four COM-B-components, i.e., capabilities (r = 0.512, p   〈  0.001), opportunities (r = 0.421, p  = 0.002), planning (r = 0.378, p  = 0.007), and motivation ( r  = 0.272, p  = 0.051). After mutual adjustment and adjustment for type of physician and the number of measures respondents felt responsible for, the final backward regression model included capabilities (β = 0.35, p  = 0.015) and planning (β = 0.29, p  = 0.041) as COM-B-correlates. Conclusion Though based on a small sample of orthopedic physicians in a single hospital (albeit in conjunction with a high survey response rate), this study found initial evidence for positive correlations between capabilities and planning skills with self-reported SSI preventive compliance in German orthopedic physicians. Analyses of the WACH-trial will further address the role of these factors in promoting SSI preventive compliance in orthopedic surgery. Trial registration : This survey was conducted as part of the research project WACH ("Wundinfektionen und Antibiotikaverbrauch in der Chirurgie" [Wound Infections and Antibiotic Consumption in Surgery]), which has been registered in the German Clinical Trial Registry ( https://www.drks.de/ ; ID: DRKS00015502).
    Type of Medium: Online Resource
    ISSN: 2047-2994
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2666706-X
    SSG: 15,3
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  • 7
    Online Resource
    Online Resource
    Oxford University Press (OUP) ; 2010
    In:  European Journal of Cardio-Thoracic Surgery Vol. 37, No. 4 ( 2010-04), p. 875-879
    In: European Journal of Cardio-Thoracic Surgery, Oxford University Press (OUP), Vol. 37, No. 4 ( 2010-04), p. 875-879
    Type of Medium: Online Resource
    ISSN: 1010-7940
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2010
    detail.hit.zdb_id: 1500330-9
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  • 8
    In: Das Gesundheitswesen, Georg Thieme Verlag KG, Vol. 83, No. 08/09 ( 2021-09), p. 624-631
    Abstract: Ziel In drei Untersuchungsgruppen (Krankenhauspatienten, Bewohner in Altenpflegeheimen und Patienten hausärztlicher Praxen) sollte die Prävalenz von Methicillin-resistentem Staphylococcus aureus (MRSA), multiresistenten gramnegativen stäbchenförmigen Bakterien (MRGN) sowie Vancomycin-resistenten Enterokokken (VRE) ermittelt werden. Zudem sollten Risikofaktoren für ein Trägertum untersucht werden. Methodik Das Screening auf multiresistente Erreger (MRE) erfolgte als Punktprävalenzuntersuchung bei freiwillig teilnehmenden Personen mittels Nasen-, Rachen- und Rektalabstrich bzw. Stuhlprobe in 25 Krankenhäusern, 14 Altenpflegeheimen sowie 33 Hausarztpraxen in 12 von 13 Landkreisen in Sachsen. Verdächtige Isolate wurden phänotypisch sowie z. T. molekularbiologisch weiter untersucht. Die Teilnehmer füllten einen Fragebogen zu vermuteten Risikofaktoren für eine MRE-Besiedlung aus, deren Angaben statistisch mittels Korrelationsanalysen ausgewertet wurden. Ergebnisse 1 718 Personen, davon 629 aus Krankenhäusern, 498 aus Altenpflegeheimen und 591 aus Arztpraxen, wurden untersucht. Insgesamt waren 8,4% aller Teilnehmer Träger eines MRE. 1,3% wurden positiv auf das Vorliegen eines MRSA, 5,2% auf 3MRGN, 0,1% auf 4MRGN und 2,3% auf VRE getestet. Neun Personen waren mit mehr als einem MRE besiedelt. Folgende unabhängige Faktoren konnten signifikant mit dem Nachweis eines MRE in Zusammenhang gebracht werden: Vorhandensein eines Pflegegrads (MRE), männliches Geschlecht (MRE/VRE), aktuelle Antibiose (MRE/VRE), Antibiose innerhalb der letzten 6 Monate (MRE/MRSA/3MRGN/VRE), aktuelle Tumorerkrankung (MRE/3MRGN), periphere arterielle Verschlusskrankheit (pAVK) (MRSA) sowie eine Harninkontinenz (3MRGN). Schlussfolgerungen Nach unserem Wissensstand stellt diese Studie die erste Untersuchung zur Prävalenz unterschiedlicher multiresistenter Erregergruppen in diesen 3 Untersuchungsgruppen und erstmals dabei auch unter ambulanten Patienten in Deutschland dar. Dabei repräsentierten 3MRGN die am häufigsten nachgewiesene Erregergruppe und fanden sich auch in jüngeren Altersgruppen wieder, VRE wurden fast ausschließlich kumuliert in einzelnen Kliniken nachgewiesen. Neben aktueller und stattgehabter Antibiose konnten insbesondere das Vorliegen einer pAVK für MRSA-Nachweise, Harninkontinenz für 3MRGN-Nachweise sowie eine aktuelle Tumorerkrankung für MRE- und 3MRGN-Nachweise als unabhängige Risikofaktoren bestimmt werden.
    Type of Medium: Online Resource
    ISSN: 0941-3790 , 1439-4421
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    Language: German
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2021
    detail.hit.zdb_id: 1101426-X
    SSG: 20,1
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  • 9
    In: Mycoses, Wiley, Vol. 48, No. s1 ( 2005-04), p. 51-55
    Abstract: Between January 2002 and December 2003 all 157 patients (pts) that underwent lung transplantation (LTx) at our institution were prospectively screened for invasive aspergillosis (IA) during their perioperative hospital stay. Patients were regarded as IA positive, if they met the EORTC criteria for ‘probable’ or ‘proven’ IA. Records of pts were screened retrospectively for antimycotic prophylaxis. Eight of the 157 pts developed ‘probable’ or ‘proven’ IA (5.1%) within 17 ± 10 days after LTx. This was associated with a 14‐fold increased mortality compared with all pts without aspergillosis ( P   〈  0.01, OR 13.8, CI 95% 2.5–82). Preoperative colonization with Aspergillus was a significant risk factor for IA ( P   〈  0.001, OR 21.9, CI 95% 4.9–97). We switched our prophylactic strategies to the primary administration of voriconazole in high risk pts (pre‐LTx colonization) starting in December 2002. Six pts (6%) of 101 pts receiving itraconazole for antimycotic prophylaxis beginning at postoperative day (POD) one developed IA, of which three pts showed cerebral aspergillosis. One pt (5%) of 18 pts receiving voriconazole prophylaxis developed IA, while 10 pts showed pretransplant colonization with Aspergillus species. Thirty‐eight pts received itraconazole prophylaxis at a later time point ( 〉 POD 14). By switching our prophylactic strategy to the use of voriconazole in high risk pts, we have decreased the incidence of IA from 8% (six of 75) in 2002 to 2% (two of 82) in 2003. This study shows a high incidence of IA during the very early postoperative course after LTx of 5%. This is associated with a significantly increased risk for mortality. Voriconazole prophylaxis appears to be superior to itraconazole, especially in high risk pts with pretransplant Aspergillus colonization.
    Type of Medium: Online Resource
    ISSN: 0933-7407 , 1439-0507
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2005
    detail.hit.zdb_id: 2020780-3
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  • 10
    Online Resource
    Online Resource
    Informa UK Limited ; 2007
    In:  Scandinavian Journal of Infectious Diseases Vol. 39, No. 5 ( 2007-01), p. 463-465
    In: Scandinavian Journal of Infectious Diseases, Informa UK Limited, Vol. 39, No. 5 ( 2007-01), p. 463-465
    Type of Medium: Online Resource
    ISSN: 0036-5548 , 1651-1980
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2007
    detail.hit.zdb_id: 2805836-7
    detail.hit.zdb_id: 1484328-6
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