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  • 11
    Online Resource
    Online Resource
    Yellow Chaste Weed and Its Components, Apigenin and Galangin, Affect Proliferation and Oxidative Stress in Blue Light-Irradiated HaCaT Cells
    MDPI AG ; 2022
    In:  Nutrients Vol. 14, No. 6 ( 2022-03-13), p. 1217-
    Details
    In: Nutrients, MDPI AG, Vol. 14, No. 6 ( 2022-03-13), p. 1217-
    Abstract: While harmful effects of blue light on skin cells have been recently reported, there are few studies regarding natural products that alleviate its negative effects. Therefore, we investigated ameliorating effects of yellow chaste weed (YCW) (Helichrysum arenarium) extract and its components, apigenin and galangin, on blue light-irradiated HaCaT cells. In this study, we found that YCW extract improved the reduced proliferation of HaCaT cells induced by blue light-irradiation and reduced blue light-induced production of reactive oxygen species (ROS) levels. We also found that apigenin and galangin, the main components of YCW extract, showed the same activities as YCW extract. In experiments examining molecular mechanisms of YCW extract and its components such as apigenin and galangin, they all reduced expression of transient receptor potential vanilloid member 1 (TRPV1), its phosphorylation, and calcium ion (Ca2+) influx induced by blue light irradiation. In addition, apigenin and galangin regulated phosphorylation of mitogen-activated protein kinases (MAPKs). They also reduced phosphorylation of mammalian sterile 20-like kinase-1/2 (MST-1/2), inducing phosphorylation of Akt (protein kinase B), one downstream molecule of MST-1/2. Moreover, apigenin and galangin promoted translocation of Forkhead box O3 (FoxO3a) from the nucleus to the cytosol by phosphorylating FoxO3a. Besides, apigenin and galangin interrupted blue light influences on expression of nuclear and secretory clusterin. Namely, they attenuated both upregulation of nuclear clusterin and downregulation of secretory clusterin induced by blue light irradiation. We also found that they downregulated apoptotic protein Bcl-2 associated X protein (Bax) and conversely upregulated anti-apoptotic protein B-cell lymphoma 2 (Bcl-2). Collectively, these findings indicate that YCW extract and its components, apigenin and galangin, antagonize the blue light-induced damage to the keratinocytes by regulating TRPV1/clusterin/FoxO3a and MAPK signaling.
    Type of Medium: Online Resource
    ISSN: 2072-6643
    URL: Article
    DOI: 10.3390/nu14061217
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2518386-2
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  • 12
    Online Resource
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    Design for Manufacturing and Assembly (DfMA) Checklists for Off-Site Construction (OSC) Projects
    MDPI AG ; 2022
    In:  Sustainability Vol. 14, No. 19 ( 2022-09-22), p. 11988-
    Details
    In: Sustainability, MDPI AG, Vol. 14, No. 19 ( 2022-09-22), p. 11988-
    Abstract: Off-Site Construction (OSC), which has the advantage of improving construction productivity, is being spotlighted as a solution to the limitations of conventional construction production methods. Despite the need for, and various advantages of, the introduction and utilization of OSC, however, several issues remain, such as design errors and reduction in design completeness, due to the lack of experience and expertise of project participants, as well as improper consideration of production environment and technical constraints. To resolve these issues, it is necessary to develop an optimal design plan that conforms to the OSC manufacturing environment and manufacturing efficiency; thus, there have been ongoing efforts in the construction industry to introduce Design for Manufacturing and Assembly (DfMA), to derive the optimal design plans for OSC projects. Some studies related to the application of DfMA to OSC have been conducted, however they neglected to present a checklist for reviewing the optimality of OSC design plans. This study has therefore developed an OSC–DfMA checklist, to review the optimality of design plans for OSC projects, by listing optimal design goals for OSC projects, the OSC process, and DfMA principles. This study utilized the systematic literature review, structured interview, and content validity analysis methods to develop the OSC–DfMA checklist presented herein. The developed OSC–DfMA checklist will be applicable to reviewing the optimality of the OSC design plans.
    Type of Medium: Online Resource
    ISSN: 2071-1050
    URL: Article
    DOI: 10.3390/su141911988
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2518383-7
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  • 13
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    Tax Exemption Grant Proposal to Promote Green Remodeling Project Implementation
    Korean Institute of Construction Engineering and Management ; 2016
    In:  Korean Journal of Construction Engineering and Management Vol. 17, No. 4 ( 2016-07-31), p. 66-75
    Details
    In: Korean Journal of Construction Engineering and Management, Korean Institute of Construction Engineering and Management, Vol. 17, No. 4 ( 2016-07-31), p. 66-75
    Type of Medium: Online Resource
    ISSN: 2005-6095
    Uniform Title: 그린리모델링 사업시행유도를 위한 조세혜택 부여 방안
    URL: Article
    DOI: 10.6106/KJCEM.2016.17.4.066
    Language: English
    Publisher: Korean Institute of Construction Engineering and Management
    Publication Date: 2016
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  • 14
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    Withaninsams A and B: Phenylpropanoid Esters from the Roots of Indian Ginseng (Withania somnifera)
    MDPI AG ; 2019
    In:  Plants Vol. 8, No. 12 ( 2019-11-20), p. 527-
    Details
    In: Plants, MDPI AG, Vol. 8, No. 12 ( 2019-11-20), p. 527-
    Abstract: Withania somnifera (L.) Dunal (Solanaceae), known as Indian ginseng or ashwagandha, has been used in Indian Ayurveda for the treatment of a variety of disorders, such as diabetes and reproductive and nervous system disorders. It is particularly used as a general health tonic, analgesic, and sedative. As part of continuing projects to discover unique bioactive natural products from medicinal plants, phytochemical investigation of the roots of W. somnifera combined with a liquid chromatography–mass spectrometry (LC/MS)-based analysis has led to the isolation of two novel phenylpropanoid esters, Withaninsams A (1) and B (2), as an inseparable mixture, along with three known phenolic compounds (3, 4, and 6) and a pyrazole alkaloid (5). The structures of the new compounds were elucidated using a combination of spectroscopic methods, including one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectroscopy (HR-ESIMS). Withaninsams A (1) and B (2) are phenylpropanoid esters that contain a side chain, 4-methyl-1,4-pentanediol unit. To the best of our knowledge, the present study is the first to report on phenylpropanoid esters with 4-methyl-1,4-pentanediol unit. The anti-inflammatory activity of the isolated compounds (1–6) was evaluated by determining their inhibitory effects on nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages, where compound 3 inhibited LPS-induced NO production (IC50 = 33.3 μM) and TNF-α production, a pro-inflammatory cytokine (IC50 = 40.9 μM). The anti-inflammatory mechanism through the inhibition of transcriptional iNOS protein expression was confirmed by western blotting experiments for the active compound 3, which showed decreased iNOS protein expression.
    Type of Medium: Online Resource
    ISSN: 2223-7747
    URL: Article
    DOI: 10.3390/plants8120527
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2704341-1
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  • 15
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    Anti-Inflammatory Effects of a Polyphenol, Catechin-7,4′-O-Digallate, from Woodfordia uniflora by Regulating NF-κB Signaling Pathway in Mouse Macrophages
    MDPI AG ; 2021
    In:  Pharmaceutics Vol. 13, No. 3 ( 2021-03-19), p. 408-
    Details
    In: Pharmaceutics, MDPI AG, Vol. 13, No. 3 ( 2021-03-19), p. 408-
    Abstract: Inflammation is a defense mechanism that protects the body from infections. However, chronic inflammation causes damage to body tissues. Thus, controlling inflammation and investigating anti-inflammatory mechanisms are keys to preventing and treating inflammatory diseases, such as sepsis and rheumatoid arthritis. In continuation with our work related to the discovery of bioactive natural products, a polyphenol, catechin-7,4′-O-digallate (CDG), was isolated from Woodfordia uniflora, which has been used as a sedative and remedy for skin infections in the Dhofar region of Oman. Thus far, no study has reported the anti-inflammatory compounds derived from W. uniflora and the mechanisms underlying their action. To investigate the effects of CDG on the regulation of inflammation, we measured the reduction in nitric oxide (NO) production following CDG treatment in immortalized mouse Kupffer cells (ImKCs). CDG treatment inhibited NO production through the downregulation of inducible nitric oxide synthase expression in lipopolysaccharide (LPS)-stimulated ImKCs. The anti-inflammatory effects of CDG were mediated via the inhibition of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activation, an important inflammatory-response-associated signaling pathway. Moreover, CDG treatment has regulated the expression of pro-inflammatory cytokines, such as IL-6 and IL-1β. These results suggested the anti-inflammatory action of CDG in LPS-stimulated ImKCs.
    Type of Medium: Online Resource
    ISSN: 1999-4923
    URL: Article
    DOI: 10.3390/pharmaceutics13030408
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2527217-2
    SSG: 15,3
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  • 16
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    Quality of Life in Food Allergy: Validation of the Korean Version of the Food Allergy Quality of Life Questionnaire Parent Form (K-FAQLQ-PF) and Risk Factor Analysis
    XMLink ; 2023
    In:  Allergy, Asthma & Immunology Research Vol. 15, No. 1 ( 2023), p. 43-
    Details
    In: Allergy, Asthma & Immunology Research, XMLink, Vol. 15, No. 1 ( 2023), p. 43-
    Type of Medium: Online Resource
    ISSN: 2092-7355 , 2092-7363
    URL: Article
    DOI: 10.4168/aair.2023.15.1.43
    Language: English
    Publisher: XMLink
    Publication Date: 2023
    detail.hit.zdb_id: 2545725-1
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  • 17
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    Study on Impacts of Regional Economic Structural Factors on Firm’ Sales using Multi-level Analysis
    Institute of Industrial and Business Management of Kyungnam University ; 2022
    In:  Regional Industry Review Vol. 45, No. 2 ( 2022-05-31), p. 3-18
    Details
    In: Regional Industry Review, Institute of Industrial and Business Management of Kyungnam University, Vol. 45, No. 2 ( 2022-05-31), p. 3-18
    Type of Medium: Online Resource
    ISSN: 2093-9027
    Uniform Title: 지역경제의 구조적 요인이 기업성과(기업매출)에 미치는 영향에 관한 연구: 다층모형을 이용하여
    URL: Article
    DOI: 10.33932/rir.45.2.1
    Language: Unknown
    Publisher: Institute of Industrial and Business Management of Kyungnam University
    Publication Date: 2022
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  • 18
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    Halogen‐Free Donor Polymers Based on Dicyanobenzotriazole with Low Energy Loss and High Efficiency in Organic Solar Cells
    Wiley ; 2023
    In:  Small Vol. 19, No. 18 ( 2023-05)
    Details
    In: Small, Wiley, Vol. 19, No. 18 ( 2023-05)
    Abstract: Halogenation of organic semiconductors is an efficient strategy for improving the performance of organic solar cells (OSCs), while the introduction of halogens usually involves complex synthetic process and serious environment pollution problems. Herein, three halogen‐free ternary copolymer donors (PCN x , x  = 3, 4, 5) based on electron‐withdrawing dicyanobenzotriazole are reported. When blended with the Y6, PCN3 with strong interchain interactions results in appropriate crystallinity and thermodynamic miscibility of the blend film. Grazing‐incidence wide‐angle X‐ray scattering measurements indicate that PCN3 has more ordered arrangement and stronger π–π stacking than previous PCN2. Fourier‐transform photocurrent spectroscopy and external quantum efficiency of electroluminescence measurements show that PCN3‐based OSCs have lower energy loss than PCN2, which leads to their higher open‐circuit voltage (0.873 V). The device based on PCN3 reaches power conversion efficiency (PCE) of 15.33% in binary OSCs, one of the highest values for OSCs with halogen‐free donor polymers. The PCE of 17.80% and 18.10% are obtained in PM6:PCN3:Y6 and PM6:PCN3:BTP‐eC9 ternary devices, much higher than those of PM6:Y6 (16.31%) and PM6:BTP‐eC9 (17.33%) devices. Additionally, this ternary OSCs exhibit superior stability compared to binary host system. This work gives a promising path for halogen‐free donor polymers to achieve low energy loss and high PCE.
    Type of Medium: Online Resource
    ISSN: 1613-6810 , 1613-6829
    URL: Issue
    URL: Article
    DOI: 10.1002/smll.v19.18
    DOI: 10.1002/smll.202206607
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2168935-0
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  • 19
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    Fracture Risk After Bariatric Surgery: Roux‐en‐Y Gastric Bypass Versus Adjustable Gastric Banding
    Wiley ; 2017
    In:  Journal of Bone and Mineral Research Vol. 32, No. 6 ( 2017-06), p. 1229-1236
    Details
    In: Journal of Bone and Mineral Research, Wiley, Vol. 32, No. 6 ( 2017-06), p. 1229-1236
    Abstract: The long‐term consequences of bariatric surgery on fracture risk are unclear but are likely to vary by procedure type. In physiologic studies, Roux‐en‐Y gastric bypass (RYGB) and adjustable gastric banding (AGB) have differential effects on rates of bone loss. Therefore, our objective was to compare fracture risk in obese adults after RYGB and AGB procedures. Using claims data from a US commercial health plan, we analyzed rates of nonvertebral fractures within a propensity score–matched cohort ( n  = 15,032) of morbidly obese adults who received either RYGB or AGB surgery between 2005 and 2013. A total of 281 nonvertebral fractures occurred during a mean follow‐up time of 2.3 ± 1.9 years. RYGB patients had an increased risk of nonvertebral fracture (hazard ratio [HR] = 1.43, 95% confidence interval [CI] 1.13–1.81) compared with AGB patients. In fracture site–specific analyses, RYGB patients had increased risk of fracture at the hip (HR = 1.54, 95% CI 1.03–2.30) and wrist (HR = 1.45, 95% CI 1.01–2.07). Nonvertebral fracture risk associated with RYGB manifested 〉 2 years after surgery and increased in subsequent years, with the highest risk in the fifth year after surgery (HR = 3.91, 95% CI 1.58–9.64). In summary, RYGB is associated with a 43% increased risk of nonvertebral fracture compared with AGB, with risk increasing 〉 2 years after surgery. Fracture risk should be considered in risk/benefit discussions of bariatric surgery, particularly among patients with high baseline risk of osteoporosis who are deciding between RYGB and AGB procedures. © 2017 American Society for Bone and Mineral Research.
    Type of Medium: Online Resource
    ISSN: 0884-0431 , 1523-4681
    URL: Issue
    URL: Article
    DOI: 10.1002/jbmr.v32.6
    DOI: 10.1002/jbmr.3101
    RVK:
    XA 52230
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2008867-X
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  • 20
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    Differences in Symptoms, Functions, and Their Outcomes According to the Degree of Trauma in Patients with Early Psychosis
    XMLink ; 2020
    In:  Journal of Korean Neuropsychiatric Association Vol. 59, No. 3 ( 2020), p. 228-
    Details
    In: Journal of Korean Neuropsychiatric Association, XMLink, Vol. 59, No. 3 ( 2020), p. 228-
    Type of Medium: Online Resource
    ISSN: 1015-4817 , 2289-0963
    URL: Article
    DOI: 10.4306/jknpa.2020.59.3.228
    Language: Korean
    Publisher: XMLink
    Publication Date: 2020
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