GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 11
    Online Resource
    Online Resource
    Prolonged progression‐free survival achieved by octreotide LAR plus transarterial embolization in low‐to‐intermediate grade neuroendocrine tumor liver metastases with high hepatic tumor burden
    Wiley ; 2022
    In:  Cancer Medicine Vol. 11, No. 13 ( 2022-07), p. 2588-2600
    Details
    In: Cancer Medicine, Wiley, Vol. 11, No. 13 ( 2022-07), p. 2588-2600
    Abstract: To evaluate the efficacy and outcome of transarterial embolization (TAE) plus octreotide long‐acting repeatable (LAR) on patients with low‐to‐intermediate neuroendocrine tumor liver metastases (NETLM). Methods One hundred and sixteen patients with G1/G2 NETLM treated with TAE plus octreotide LAR at the First Affiliated Hospital, Sun Yat‐sen University between January 12, 2016 and September 24, 2020 were reviewed. Radiological response was evaluated according to response evaluation criterion in solid tumor version 1.1. Overall progression‐free survival (PFS) was assessed. Intrahepatic and extrahepatic PFS were evaluated in the whole cohort and in patients with the extrahepatic disease (EHD), respectively. Factors affecting treatment response and overall PFS were analyzed using the logistic regression model and Cox proportional hazard model. Adverse events were recorded and evaluated according to Common Terminology Criteria for Adverse Events 5.0. Results The median overall PFS of the whole cohort was 13.6 months. For the patients with EHD, the median intrahepatic PFS and extrahepatic PFS were 13.6 and 26.1 months, respectively. The median overall PFS of patients with hepatic tumor burden (HTB) 〈 10%, 10%–25%, 25%–50%, and 〉 50% were 25.2, 13.6, 11.2, and 12.3 months, respectively. Ki67 〉 10%, HTB 〉 50%, and bone metastasis were independently associated with overall PFS. The objective response rate was 78.4%. In patients with HTB 25%–50% and 〉 50%, responders (complete response or partial response) had significant prolonged PFS compared with nonresponders (stable disease or progression disease). Ki67 〉 10%, bone metastasis, and clear tumor margin were independently associated with response to TAE. The most frequent adverse events that occurred after TAE were postembolization syndrome, and no treatment‐associated death occurred during the perioperative period. Conclusion Transarterial embolization plus octreotide LAR can significantly prolong the PFS of neuroendocrine tumor liver metastases, especially with high HTB over 50%. Selected patients with HTB 〉 25% (ki67 ≤10%, absence of bone metastasis, clear tumor margin) could derive prognostic advantage from the combined treatment.
    Type of Medium: Online Resource
    ISSN: 2045-7634 , 2045-7634
    URL: Issue
    URL: Article
    DOI: 10.1002/cam4.v11.13
    DOI: 10.1002/cam4.4628
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2659751-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 12
    Online Resource
    Online Resource
    Preface to Special Topic on Atmospheric Greenhouse Gas Measurement and Application in China
    Springer Science and Business Media LLC ; 2020
    In:  Advances in Atmospheric Sciences Vol. 37, No. 6 ( 2020-06), p. 555-556
    Details
    In: Advances in Atmospheric Sciences, Springer Science and Business Media LLC, Vol. 37, No. 6 ( 2020-06), p. 555-556
    Type of Medium: Online Resource
    ISSN: 0256-1530 , 1861-9533
    URL: Article
    DOI: 10.1007/s00376-020-9300-x
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2228064-9
    SSG: 6,25
    SSG: 16,13
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 13
    Online Resource
    Online Resource
    Overexpression of HMGA2 Promotes Metastasis and Impacts Survival of Colorectal Cancers
    American Association for Cancer Research (AACR) ; 2011
    In:  Clinical Cancer Research Vol. 17, No. 8 ( 2011-04-15), p. 2570-2580
    Details
    In: Clinical Cancer Research, American Association for Cancer Research (AACR), Vol. 17, No. 8 ( 2011-04-15), p. 2570-2580
    Abstract: Purpose: This study aims to address the hypothesis that the high-mobility group A2 (HMGA2), an oncofetal protein, relates to survivability and serves as a prognostic biomarker for colorectal cancer (CRC). Experimental Design: This is a retroprospective multiple center study. The HMGA2 expression level was determined by performing immunohistochemistry on surgical tissue samples of 89 CRCs from a training set and 191 CRCs from a validation set. The Kaplan–Meier analysis and COX proportional hazard model were employed to analyze the survivability. Results: Multivariate logistic analysis indicated that the expression of HMGA2 significantly correlates with distant metastasis in training set (odds ratio, OR = 3.53, 95% CI: 1.37–9.70) and validation set (OR = 6.38, 95% CI: 1.47–43.95). Survival analysis revealed that the overexpression of HMGA2 is significantly associated with poor survival of CRC patients (P & lt; 0.05). The adjusted HRs for overall survival were 2.38 (95% CI: 1.30–4.34) and 2.14 (95% CI: 1.21–3.79) in training and validation sets, respectively. Further investigation revealed that HMGA2 delays the clearance of γ-H2AX in HCT-116 and SW480 cells post γ-irradiation, which supports our finding that CRC patients with HMAG2-positive staining in primary tumors had augmented the efficacy of adjuvant radiotherapy (HR = 0.18, 95% CI: 0.04–0.63). Conclusion: Overexpression of HMGA2 is associated with metastasis and unequivocally occurred in parallel with reduced survival rates of patients with CRC. Therefore, HMGA2 may potentially serve as a biomarker for predicting aggressive CRC with poor survivability and as an indicator for better response of radiotherapy. Clin Cancer Res; 17(8); 2570–80. ©2011 AACR.
    Type of Medium: Online Resource
    ISSN: 1078-0432 , 1557-3265
    URL: Article
    DOI: 10.1158/1078-0432.CCR-10-2542
    RVK:
    XA 36791
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2011
    detail.hit.zdb_id: 1225457-5
    detail.hit.zdb_id: 2036787-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 14
    Online Resource
    Online Resource
    Apatinib Combined With Transarterial Chemoembolization in Patients With Hepatocellular Carcinoma and Portal Vein Tumor Thrombus: A Multicenter Retrospective Study
    Elsevier BV ; 2019
    In:  Clinical Therapeutics Vol. 41, No. 8 ( 2019-08), p. 1463-1476
    Details
    In: Clinical Therapeutics, Elsevier BV, Vol. 41, No. 8 ( 2019-08), p. 1463-1476
    Type of Medium: Online Resource
    ISSN: 0149-2918
    URL: Article
    DOI: 10.1016/j.clinthera.2019.04.036
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2019
    detail.hit.zdb_id: 2025417-9
    SSG: 15,3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 15
    Online Resource
    Online Resource
    Dynamic acquisition pricing policy under uncertain remanufactured-product demand
    Emerald ; 2015
    In:  Industrial Management & Data Systems Vol. 115, No. 3 ( 2015-4-13), p. 521-540
    Details
    In: Industrial Management & Data Systems, Emerald, Vol. 115, No. 3 ( 2015-4-13), p. 521-540
    Abstract: – The purpose of this paper is to investigate the dynamic acquisition pricing strategy for collecting used products (also known as cores or returns) in a finite planning horizon. In particular, this paper studies a cost-minimization model in which a firm offers acquisition price that impacts the quantity of the returns, and remanufactures the used product to satisfy the customer demand. Design/methodology/approach – This paper uses multi-period stochastic dynamic programming theory to model a remanufacturing system that faces the random demand for remanufactured products. The number of the returns at each period is uncertain and increases linearly with the acquisition price offered. Findings – The study shows that when the uncertainty of demand for remanufactured products increases, the remanufacturer should hold a higher core stock level to minimize the expected total cost and thus a higher acquisition price is needed to attract returns. However, given demand uncertainty, the optimal price decreases in the initial core stock level in each period. It also indicates that the optimal acquisition price increases in the variance of the returns, but decreases in the mean of the returns. Practical implications – The findings suggest that a remanufacturer could reduce the expected total cost by adjusting the acquisition price according to the number of returns periodically. Originality/value – Introducing the impact of supply uncertainty on the acquisition price of used products, this paper uses a multi-period dynamic model, instead of single period model in previous studies, to examine the remanufacturer’s dynamic acquisition pricing policy.
    Type of Medium: Online Resource
    ISSN: 0263-5577
    URL: Article
    DOI: 10.1108/IMDS-11-2014-0333
    Language: English
    Publisher: Emerald
    Publication Date: 2015
    detail.hit.zdb_id: 2002327-3
    SSG: 3,2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 16
    Online Resource
    Online Resource
    Transcriptome sequencing and metabolome analysis reveal the metabolic reprogramming of partial hepatectomy and extended hepatectomy
    Springer Science and Business Media LLC ; 2023
    In:  BMC Genomics Vol. 24, No. 1 ( 2023-09-07)
    Details
    In: BMC Genomics, Springer Science and Business Media LLC, Vol. 24, No. 1 ( 2023-09-07)
    Abstract: Surgical resection remains a critical treatment option for many patients with primary and secondary hepatic neoplasms. Extended hepatectomy (eHx) may be required for some patients with large tumors, which may cause liver failure and death. Partial hepatectomy (pHx) and eHx mouse models were constructed, liver tissues were sampled at 18, 36, and 72 h posthepatectomy. Transcriptome and metabolome analyses were employed to explore the different potential mechanisms in regeneration and injury between pHx and eHx. The results showed that eHx was associated with more severe liver injury and lower survival rates than pHx. Transcriptomics data showed there were 1842, 2129, and 1277 differentially expressed genes (DEGs) in eHx and 962, 1305, and 732 DEGs in pHx at 18, 36, and 72 h posthepatectomy, respectively, compared with the those in the sham groups. Compared with pHx, the number of DEGs in the eHx group reached a maximum of 230 at 18 h after surgery and decreased sequentially to 87 and 43 at 36 and 72 h. Metabolomics analysis identified a total of 1399 metabolites, and 48 significant differentially produced metabolites (DPMs) were screened between eHx and pHx. Combined analysis of DEGs and DPMs indicated that cholesterol metabolism and insulin resistance may be two important pathways for liver regeneration and mouse survival postextended hepatectomy. Our results showed the global influence of pHx and eHx on the transcriptome and metabolome in mouse liver, and revealed cholesterol metabolism and insulin resistance pathways might be involved in regeneration post-pHx and -eHx.
    Type of Medium: Online Resource
    ISSN: 1471-2164
    URL: Article
    DOI: 10.1186/s12864-023-09647-0
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2041499-7
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 17
    Online Resource
    Online Resource
    Capecitabine-induced enterocolitis: a case report and pharmacogenetic profile
    Future Medicine Ltd ; 2022
    In:  Pharmacogenomics Vol. 23, No. 18 ( 2022-12), p. 953-959
    Details
    In: Pharmacogenomics, Future Medicine Ltd, Vol. 23, No. 18 ( 2022-12), p. 953-959
    Abstract: Capecitabine is a widely-used antineoplastic drug, a prodrug to 5-fluorouracil which commonly induces gastrointestinal toxicity. Enterocolitis, as a rarely recognized gastrointestinal adverse effect (AE) of capecitabine, is potentially severe and usually results in antitumor treatment withdrawal. For the better management of severe AEs, pharmacogenetics is one promising field. Herein, we describe a case of capecitabine-induced enterocolitis presenting with severe diarrhea in order to improve recognition by clinicians. Moreover, we conduct a pharmacogenetic profile of the patient and review the current studies of gene polymorphisms of 5-fluorouracil-related diarrhea, hoping to offer a reference for further clinical pharmacogenetic practice in predicting capecitabine AEs showing diarrhea as the main symptom.
    Type of Medium: Online Resource
    ISSN: 1462-2416 , 1744-8042
    URL: Article
    DOI: 10.2217/pgs-2022-0124
    Language: English
    Publisher: Future Medicine Ltd
    Publication Date: 2022
    SSG: 15,3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 18
    Online Resource
    Online Resource
    Precipitation and Residual Stress Relaxation Kinetics in Shot-Peened Inconel 718
    Springer Science and Business Media LLC ; 2006
    In:  Journal of Materials Engineering and Performance Vol. 15, No. 5 ( 2006-10-01), p. 614-617
    Details
    In: Journal of Materials Engineering and Performance, Springer Science and Business Media LLC, Vol. 15, No. 5 ( 2006-10-01), p. 614-617
    Type of Medium: Online Resource
    ISSN: 1059-9495 , 0000-0000
    URL: Article
    DOI: 10.1361/105994906X124613
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2006
    detail.hit.zdb_id: 2048384-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 19
    Online Resource
    Online Resource
    Gradient characterization of steel-concrete interface at early ages
    Elsevier BV ; 2023
    In:  Cement and Concrete Composites Vol. 137 ( 2023-03), p. 104941-
    Details
    In: Cement and Concrete Composites, Elsevier BV, Vol. 137 ( 2023-03), p. 104941-
    Type of Medium: Online Resource
    ISSN: 0958-9465
    URL: Article
    DOI: 10.1016/j.cemconcomp.2023.104941
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 1502279-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 20
    Online Resource
    Online Resource
    Prevalence, Influencing Factors, Antibiotic Resistance, Toxin and Molecular Characteristics of Staphylococcus aureus and MRSA Nasal Carriage among Diabetic Population in the United States, 2001–2004
    Polish Society of Microbiologists ; 2017
    In:  Polish Journal of Microbiology Vol. 66, No. 4 ( 2017-01-01), p. 439-448
    Details
    In: Polish Journal of Microbiology, Polish Society of Microbiologists, Vol. 66, No. 4 ( 2017-01-01), p. 439-448
    Abstract: Diabetic population were reported more likely to suffer carriage and infection with Staphylococcus aureus ( S. aureus ) and methicillin-resistant Staphylococcus aureus (MRSA) than non-diabetic population. We aim to elucidate the prevalence and characteristics of S. aureus and MRSA nasal carriage among diabetic population in the United States National Health and Nutrition Examination Survey, 2001–2004. Univariate analyses were conducted using Chi-square test, Fisher’s exact probability test or student t test, as appropriate. Multivariate analysis using logistic regression was conducted to assess the association between influencing factors and S. aureus and MRSA nasal carriage. 1010 diabetic participants were included in the study. The prevalence of S. aureus and MRSA nasal carriage were 28.32% and 1.09%, respectively. After the logistic regression, ever had a painful sensation or tingling in hands or feet past three months (Odds Ratio [OR] = 0.359, 95% Confidence Interval [CI] , 0.146–0.882) was significant among S. aureus nasal carriage and gender (OR = 3.410, 95% CI, 1.091–10.653) was significant among MRSA nasal carriage. The proportions of staphylococcal enterotoxin (SE) A, SEB, SEC, SED, Toxic-shock syndrome toxin-1, and Panton Valentine Leukocidin toxin among S. aureus strains were 18.75%, 3.13%, 12.50%, 15.63%, 28.13%, and 9.38%, respectively. 63.63% of MRSA strains were community-acquired, 27.27% were hospital-acquired, and 9.09% were non-typeable. Diabetic patients might be more likely to carry S. aureus and MRSA in the United States. Improving hand hygiene compliance, reducing antibiotic overuse, screening for carriers, and decolonization are recommended to reduce the spread of S. aureus and MRSA, especially in community.
    Type of Medium: Online Resource
    ISSN: 2544-4646
    URL: Article
    DOI: 10.5604/01.3001.0010.7038
    Language: English
    Publisher: Polish Society of Microbiologists
    Publication Date: 2017
    detail.hit.zdb_id: 2234080-4
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...