In:
Advanced Synthesis & Catalysis, Wiley, Vol. 363, No. 5 ( 2021-03-02), p. 1408-1416
Abstract:
Herein, a base‐controlled protocol was developed for the C−N coupling of primary amines and 2‐chlorobenzimidazoles, affording a handful of secondary or tertiary amines in a selective fashion. Moreover, this protocol was realized under transition‐metal‐free conditions, and the variation of the base from i Pr 2 NH to LiO t Bu completely switched the selectivity from monoarylation to diarylation. Further investigations elucidated that the variety, intrinsic basicity and amount of the utilized bases considerably affected these reactions. magnified image
Type of Medium:
Online Resource
ISSN:
1615-4150
,
1615-4169
DOI:
10.1002/adsc.202001365
Language:
English
Publisher:
Wiley
Publication Date:
2021
detail.hit.zdb_id:
2041384-1
detail.hit.zdb_id:
2033084-4
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