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  • 11
    Online Resource
    Online Resource
    Relationship Between History of Hormonal Contraception with Hormonal Receptor’s Expression on Breast Cancer Patients in Mohammad Hoesin General Hospital Palembang
    Hanif Medisiana Publisher ; 2021
    In:  Sriwijaya Journal of Surgery Vol. 4, No. 1 ( 2021-03-09), p. 185-194
    Details
    In: Sriwijaya Journal of Surgery, Hanif Medisiana Publisher, Vol. 4, No. 1 ( 2021-03-09), p. 185-194
    Abstract: Background: Cancers with esterogen receptor negative (ER-) have a worse prognostic than estrogen receptor positive (ER +). Research by Cooper at al and Huiyan Ma et al have found strong association between history of hormonal contraceptive use and breast cancer with receptor negative estrogen (ER -). However, another study from Cotterchio et al found no difference. Methods: This study investigated breast cancer patients who went to dr. Moh Hoesin Palembang. This study involved 200 respondents with data obtained using patient immunohistochemical data and interviews using a questionnaire. This study uses a cross sectional analysis method. Data were obtained from the history of use of hormonal contraception, the type of hormonal contraception, and the status of hormonal receptors (Esterogen Receptors (ER) and Progesterone receptors (PR). 2x2 tables were used to obtain the Prevalence Ratio (PRR) and chi quare to obtain p values. Results: The results of the Chi square analysis showed that there was no significant relationship between the history of hormonal contraception and negative receptor expression with the prevalence ratio of hormonal contraceptives and ER (-) 1.48 times and PR (-) 1.43 times. There was no significant relationship between type of contraception and negative ER PR. The highest relative risk is in implant contraception with 1.54 times for ER (-) and 1.8 times for PR (-) Conclusion: There was no relationship between the history of hormonal contraception and negative hormonal receptors
    Type of Medium: Online Resource
    ISSN: 2722-3558
    URL: Issue
    URL: Article
    DOI: 10.37275/sjs.v4i1
    DOI: 10.37275/sjs.v4i1.45
    Language: Unknown
    Publisher: Hanif Medisiana Publisher
    Publication Date: 2021
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  • 12
    Online Resource
    Online Resource
    Overall Survival for Stage III Breast Cancer Patients at DR. Mohammad Hoesin General Hospital Palembang and the Influencing Factors
    National Cancer Center Dharmais Cancer Hospital ; 2022
    In:  Indonesian Journal of Cancer Vol. 16, No. 4 ( 2022-12-28), p. 231-
    Details
    In: Indonesian Journal of Cancer, National Cancer Center Dharmais Cancer Hospital, Vol. 16, No. 4 ( 2022-12-28), p. 231-
    Abstract: Background: There is still a limited number of studies related to overall survival in breast cancer patients in Indonesia. This study determines the overall survival and the factor which can affect the survival of stage III breast cancer patients.Methods: This study was a retrospective study. Patients first diagnosed with stage III breast cancer from January 1 to August 31, 2018, at DR. Mohammad Hoesin General Hospital Palembang had been studied. The primary outcome of this study was overall survival. The sociodemographic, clinicopathology, and treatment factors were analyzed to identify the independent variables associated with overall survival using Kaplan-Meier and Cox proportional hazard regression.Results: In this study, 78 samples were included. The 3-year overall survival for stage III breast cancer was 71%. In the bivariate analysis, several factors including older age ( 〉 40) (HR = 2.795, 95% CI 1.223–6.387), higher stages for IIIB (HR = 7.155, 95% CI 0.960–53.334), and IIIC (HR = (HR = 33.450, 95% CI 3.013-371.354), history of not undergoing surgical intervention (HR = 3.999, 95% CI 1.684–9.495), and adjuvant chemotherapy (HR = 2.768, 95% CI 1.211–6.327) have been associated significantly to lower overall survival. Multivariate analysis showed IIIC breast cancer stage as an independent factor and had a significantly increased probability of mortality (HR = 14.677, 95% CI 1.268–169.948).Conclusions: The stage at diagnosis was the only significant predictor for the survival outcome, indicating that early diagnosis may need more attention.
    Type of Medium: Online Resource
    ISSN: 2355-6811 , 1978-3744
    URL: Issue
    URL: Article
    DOI: 10.33371/ijoc.v16i4
    DOI: 10.33371/ijoc.v16i4.905
    Language: Unknown
    Publisher: National Cancer Center Dharmais Cancer Hospital
    Publication Date: 2022
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  • 13
    Online Resource
    Online Resource
    AGE, MOLECULAR SUBTYPE, AND SITES OF METASTASIS IN BREAST CANCER PATIENTS WITH DISTANT METASTASIS IN RSMH PALEMBANG
    Universitas Udayana ; 2022
    In:  E-Jurnal Medika Udayana Vol. 11, No. 9 ( 2022-09-27), p. 98-
    Details
    In: E-Jurnal Medika Udayana, Universitas Udayana, Vol. 11, No. 9 ( 2022-09-27), p. 98-
    Abstract: About 90% of cancer-related deaths are caused by distant metastases. Age at diagnosis and molecular subtypes can be used to predict the event of distant metastases. This study aims to determine age and location preference for distant metastases based on tumor molecular subtypes in breast cancer patients. This study was a descriptive observational study with a cross-sectional design. The sample in this study were breast cancer patients with distant metastases, both de novo and recurrent metastases, at Dr. Mohammad Hoesin for the period January - December 2018 who were recorded in the medical record and met the research criteria. There were 93 patients with distant metastatic breast cancer (17 patients with de novo metastases; 76 recurrent metastases). In the de novo and recurrent metastatic groups, most of the patients were ?40-60 years (52.9% and 67.1%). The most common sites of metastases were the lungs (34.4%) and bone (25.8%). Luminal A subtype metastasized dominantly to lungs (45%), luminal B to bone (34.1%), HER2-enriched to  lungs (50%), and TNBC to lungs (57.4%) and liver (28.6%). The highest percentage of breast cancer patients with distant metastases in Dr. Mohammad Hoesin Palembang was found in the age group ?40?60 years. The most common sites for metastases are lungs and bones. Most luminal A and HER2-enriched subtypes metastasized to lungs, luminal B to bone, and TNBC to lungs and liver. Keywords: Age, Subtype, Metastatis Site, Distant Metastatis Breast Cancer
    Type of Medium: Online Resource
    ISSN: 2303-1395
    URL: Article
    DOI: 10.24843/MU.2022.V11.i9.P18
    Language: Unknown
    Publisher: Universitas Udayana
    Publication Date: 2022
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  • 14
    Online Resource
    Online Resource
    Association Between Ki67 After Neoadjuvant Chemotherapy and Disease-Free Survival in Breast Cancer.
    Hanif Medisiana Publisher ; 2021
    In:  Sriwijaya Journal of Surgery Vol. 4, No. 2 ( 2021-05-25), p. 219-239
    Details
    In: Sriwijaya Journal of Surgery, Hanif Medisiana Publisher, Vol. 4, No. 2 ( 2021-05-25), p. 219-239
    Abstract: Background: Post Chemotherapy Ki67 in recent year has been investigated as a predictive and prognostic factor in locally advanced breast cancer patient undergoing neoadjuvant chemotherapy. Objectives: To describe the relationship between post-chemotherapy Ki67 and disease-free survival after neoadjuvant chemotherapy in patients with locally advanced breast cancer at Dr. Hospital. Mohammad Hoesin Palembang. Methods: This study is an analytical observational study with prognostic test design conducted in 30 stage III B breast cancer patient. A retrospective search of a prospectively maintained clinical database was performed to identify patient treated with neoadjuvant chemotherapy at the Mohammad Hoesin Hospital. The expression of Ki67 was assessed using immunohisto-chemistry in post therapy surgical excision specimen. Results: From 30 patients, there was a significant relationship between Post Chemotherapy Ki67 and disease- free survival in patients with locally advanced breast cancer (r = -0,742, p = 0.000). The cut off point value of Ki67 was 27,5% with an area under curve (AUC) of 0,716. The results of the post-chemotherapy Ki67 prognosis test included sensitivity 64%, specificity 60%, Positive Predictive Value 88,9%, Negative Predictive Value 25%, accuracy 63,3%. Conclusion: There is a significant relationship between Post Chemotherapy Ki67 to disease free survival and Post Chemotherapy Ki67 can be used as a prognostic biomarker in breast carcinoma patients undergoing neoadjuvant chemotherapy.
    Type of Medium: Online Resource
    ISSN: 2722-3558
    URL: Issue
    URL: Article
    DOI: 10.37275/sjs.v4i2
    DOI: 10.37275/sjs.v4i2.57
    Language: Unknown
    Publisher: Hanif Medisiana Publisher
    Publication Date: 2021
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  • 15
    Online Resource
    Online Resource
    Platelet/Lymphocyte Ratio Accuracy as Predictor of Neo-Adjuvant Chemotherapy Response in Locally Advanced Breast Cancer at Dr. Mohammad Hoesin General Hospital Palembang
    Hanif Medisiana Publisher ; 2021
    In:  Sriwijaya Journal of Surgery Vol. 4, No. 1 ( 2021-05-17), p. 261-273
    Details
    In: Sriwijaya Journal of Surgery, Hanif Medisiana Publisher, Vol. 4, No. 1 ( 2021-05-17), p. 261-273
    Abstract: Background: Platelet/lymphocyte ratio (PLR) is considered as predictor for chemotherapy response in locally advanced breast cancer undergoing neo-adjuvant chemotherapy. This study aims to evaluate the relationship between the platelet/lymphocyte ratio and neo-adjuvant chemotherapy response in patients with locally advanced breast cancer at Dr. Mohammad Hoesin General Hospital Palembang. Methods: This study is a prognostic test of the platelet/lymphocyte ratio accuracy to predict the response of neo-adjuvant chemotherapy in patients with locally advanced breast cancer. The study included 113 subjects. Results: From 113 patients, the PLR cut off point value was 206.83 with an under curve area (AUC) of 91.8%. The results of the PLR prognostic test were sensitivity of 98%, specificity of 87%, Positive Predictive Value of 95%, Negative Predictive Value of 93%, and 95% of accuracy. There was a significant relationship between PLR and chemotherapy response in patients with locally advanced breast cancer (p = 0.000). Conclusion: There was a significant relationship between PLR on chemotherapy response. PLR can be used as a predictor of neo-adjuvant chemotherapy response with a good degree of accuracy.
    Type of Medium: Online Resource
    ISSN: 2722-3558
    URL: Issue
    URL: Article
    DOI: 10.37275/sjs.v4i1
    DOI: 10.37275/sjs.v4i1.54
    Language: Unknown
    Publisher: Hanif Medisiana Publisher
    Publication Date: 2021
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  • 16
    Online Resource
    Online Resource
    Effects of Neo-Adjuvant Chemotherapy on CD8 + Serum Levels in Local Advanced Stage Breast Cancer Patients
    Hanif Medisiana Publisher ; 2020
    In:  Sriwijaya Journal of Surgery Vol. 3, No. 1 ( 2020-06-28), p. 45-60
    Details
    In: Sriwijaya Journal of Surgery, Hanif Medisiana Publisher, Vol. 3, No. 1 ( 2020-06-28), p. 45-60
    Abstract: Introduction.CD8 + CTLs are important components of tumor specific cellular adaptive immunity in breast cancer. Chemotherapy can increase the response of cytotoxic lymphocytes and provide anti-tumor immunity. Therefore, chemotherapy can cause cell death and trigger tumor antigens that are processed by APC and activate CD8 + cells to destroy tumor cells. Evaluation of the immune system before treatment can predict chemotherapy response. The purpose of this study was to assess the effect of neo-adjuvant chemotherapy on serum CD8 + levels in patients with locally advanced breast cancer.Methods.Non-comparative clinical trials were conducted at Dr. Mohammad Hoesin Hospital Palembang from October 2017 to June 2018.The sample of this study was 30 breast cancer patients who met the inclusion criteria. All samples underwent FAC neo-adjuvant chemotherapy and data were analyzed with SPSS version 21. Results.The mean age of advanced breast cancer patients was 45.97 ± 10,526 years with an age range of 30-66 years. Serum CD8 + levels after chemotherapy decreased significantly compared to before chemotherapy (p = 0.000). The value of serum CD8 + before chemotherapy has a sensitivity of 42.86% and specificity of 43.48% with a cut of point of 660.7 cells / mm3.Conclusion.Neo-adjuvant chemotherapy significantly decreases serum CD8 + levels in local advanced breast cancer patients.Keyword: CD8 +, locally advanced breast cancer, immune system, neo-adjuvant chemotherapy  
    Type of Medium: Online Resource
    ISSN: 2722-3558
    URL: Issue
    URL: Article
    DOI: 10.37275/sjs.v3i1
    DOI: 10.37275/sjs.v3i1.27
    Language: Unknown
    Publisher: Hanif Medisiana Publisher
    Publication Date: 2020
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  • 17
    Online Resource
    Online Resource
    Neoadjuvan Chemotheraphy Responses to Local Advanced Breast Cancer Patients at Dr Moh Hoesin Hospital Palembang
    Universitas Sriwijaya (Relawan) ; 2020
    In:  SRIWIJAYA JOURNAL OF MEDICINE Vol. 3, No. 3 ( 2020-10-23), p. 51-58
    Details
    In: SRIWIJAYA JOURNAL OF MEDICINE, Universitas Sriwijaya (Relawan), Vol. 3, No. 3 ( 2020-10-23), p. 51-58
    Abstract: Breast cancer is a malignancy which invaded breast tissue in the form of ductal or lobular. One most therapywhich is given is neoadjuvant chemotherapy. Neoadjuvant Chemotherapy can reduce tumor size so that surgerycan be performed with good breast removal with Modification of Radical Mastectomy (MRM) and BreastConservative Therapy (BCT). This purpose from this research is to find out neoadjuvant chemotherapy response inLocally Advanced Breast Cancer Patients which has received chemotherapy treatment in RSUP dr MohammadHoesin Palembang. This observational descriptive study was conducted at RSUP Mohammad Hoesin Palembang inthe period between October until November 2019. The sample of this study was locally advanced breast Cancerpatients who underwent chemotherapy that met the inclusion and exclusion criteria. The data were obtained byinterviews and observed medical records from the patients which were then analyzed by univariate analysis usingSPSS version 25. In this study there were 34 locally advanced breast cancer patients who fulfilled the inclusion andexclusion criteria. 24 of 34 patients (70,6%) received positive response and 10 of 34 patients (29,4%) receivednegative response.
    Type of Medium: Online Resource
    ISSN: 2622-3589
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.32539/sjm.v3i3
    DOI: 10.32539/sjm
    DOI: 10.32539/sjm.v3i3.131
    Language: Unknown
    Publisher: Universitas Sriwijaya (Relawan)
    Publication Date: 2020
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  • 18
    Online Resource
    Online Resource
    The Description of Hormonal Risk Factors of Breast Cancer Patients in RSUP Dr. Mohammad Hoesin Palembang
    Universitas Udayana ; 2021
    In:  E-Jurnal Medika Udayana Vol. 10, No. 8 ( 2021-08-31), p. 39-
    Details
    In: E-Jurnal Medika Udayana, Universitas Udayana, Vol. 10, No. 8 ( 2021-08-31), p. 39-
    Abstract: Breast cancer is a multifactorial disease. Most of the breast cancer risk factors are hormonal risk factors that associated with the length of exposure to estrogen hormone. This study is aimed to know the description of hormonal risk factors of breast cancer patients in RSUP Dr. Mohammad Hoesin Palembang. This study is a descriptive-observational study with cross-sectional design. Samples in this study are medical records of breast cancer patients in RSUP Dr. Mohammad Hoesin Palembang during January 2019 – August 2020 that meet the inclusion and exclusion criteria. In this study, 97 breast cancer patients were included as participant. Most of the participants had menarche at the age of 12 – 14 (72.2%), menopause at the age of 45 – 54 (38.1%), first pregnancy at the age of 20 – 29 (48.5%), parity  ? 3 times (46.4%), breastfed (76.3%), used hormonal contraception (71.1%), not used any menopausal hormone (96.9%), not consumed alcohol (100%) and normal nutritional status (56.7%).  
    Type of Medium: Online Resource
    ISSN: 2303-1395
    URL: Article
    DOI: 10.24843/MU.2021.V10.i8.P07
    Language: Unknown
    Publisher: Universitas Udayana
    Publication Date: 2021
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