In:
Frontiers in Immunology, Frontiers Media SA, Vol. 13 ( 2022-3-10)
Abstract:
Immunotherapy, closely associated with immune infiltration and tumor mutation burden (TMB), is emerging as a promising strategy for treating tumors, but its low response rate in hepatocellular carcinoma (HCC) remains a major challenge. Herein, we applied two algorithms to uncover the immune infiltration landscape of the immune microenvironment in 491 HCC patients. Three immune infiltration patterns were defined using the CIBERSORT method, and the immune cell infiltration (ICI) scores were established using principal component analysis. In the high ICI score group, the activation of the Wnt/β-catenin pathway was significantly enriched and expressions of immune checkpoint genes increased, which showed a pessimistic outcome. The low ICI score group was characterized by increased TMB and enrichment of metabolism-related pathways. Further analysis found that the ICI score exhibited a significant difference in age ≥65/age & lt;65, grade I/grade II–IV, and response to immunotherapy. Moreover, the CTNNB1 mutation status was found to be closely associated with prognosis and immunotherapeutic efficiency, significantly affecting the ICI score and TMB, which might be regarded as a potential marker for the treatment of HCC. The evaluation of immune infiltration patterns can improve the understanding of the tumor immune microenvironment and provide new directions for the study of individualized immunotherapy strategies for HCC.
Type of Medium:
Online Resource
ISSN:
1664-3224
DOI:
10.3389/fimmu.2022.861525
DOI:
10.3389/fimmu.2022.861525.s001
DOI:
10.3389/fimmu.2022.861525.s002
DOI:
10.3389/fimmu.2022.861525.s003
DOI:
10.3389/fimmu.2022.861525.s004
DOI:
10.3389/fimmu.2022.861525.s005
DOI:
10.3389/fimmu.2022.861525.s006
DOI:
10.3389/fimmu.2022.861525.s007
DOI:
10.3389/fimmu.2022.861525.s008
DOI:
10.3389/fimmu.2022.861525.s009
DOI:
10.3389/fimmu.2022.861525.s010
DOI:
10.3389/fimmu.2022.861525.s011
DOI:
10.3389/fimmu.2022.861525.s012
DOI:
10.3389/fimmu.2022.861525.s013
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2022
detail.hit.zdb_id:
2606827-8
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