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  • 11
    Online Resource
    Online Resource
    Early Plasmapheresis Among Patients With Hypertriglyceridemia–Associated Acute Pancreatitis
    American Medical Association (AMA) ; 2023
    In:  JAMA Network Open Vol. 6, No. 6 ( 2023-06-28), p. e2320802-
    Details
    In: JAMA Network Open, American Medical Association (AMA), Vol. 6, No. 6 ( 2023-06-28), p. e2320802-
    Abstract: The incidence of hypertriglyceridemia–associated acute pancreatitis (HTG-AP) is increasing. Plasmapheresis is theoretically effective in removing triglyceride from plasma, but whether it confers clinical benefits is unclear. Objective To assess the association between plasmapheresis and the incidence and duration of organ failure among patients with HTG-AP. Design, Setting, and Participants This is an a priori analysis of data from a multicenter, prospective cohort study with patients enrolled from 28 sites across China. Patients with HTG-AP were admitted within 72 hours from the disease onset. The first patient was enrolled on November 7th, 2020, and the last on November 30th, 2021. The follow-up of the 300th patient was completed on January 30th, 2022. Data were analyzed from April to May 2022. Exposures Receiving plasmapheresis. The choice of triglyceride-lowering therapies was at the discretion of the treating physicians. Main Outcomes and Measures The primary outcome was organ failure–free days to 14 days of enrollment. Secondary outcomes included other measures for organ failure, intensive care unit (ICU) admission, duration of ICU and hospital stays, incidence of infected pancreatic necrosis, and 60-day mortality. Propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) analyses were used to control potential confounders. Results Overall, 267 patients with HTG-AP were enrolled (185 [69.3%] were male; median [IQR] age, 37 [31-43] years), among whom 211 underwent conventional medical treatment and 56 underwent plasmapheresis. PSM created 47 pairs of patients with balanced baseline characteristics. In the matched cohort, no difference was detected concerning organ failure–free days between patients undergoing plasmapheresis or not (median [IQR] , 12.0 [8.0-14.0] vs 13.0 [8.0-14.0] ; P  = .94). Moreover, more patients in the plasmapheresis group required ICU admission (44 [93.6%] vs 24 [51.1%] ; P   & amp;lt; .001). The IPTW results conformed to the results from the PSM analysis. Conclusions and Relevance In this large multicenter cohort study of patients with HTG-AP, plasmapheresis was commonly used to lower plasma triglyceride. However, after adjusting for confounders, plasmapheresis was not associated with the incidence and duration of organ failure, but with increased ICU requirements.
    Type of Medium: Online Resource
    ISSN: 2574-3805
    URL: Article
    DOI: 10.1001/jamanetworkopen.2023.20802
    Language: English
    Publisher: American Medical Association (AMA)
    Publication Date: 2023
    detail.hit.zdb_id: 2931249-8
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  • 12
    Online Resource
    Online Resource
    Rigid–Flexible Coupled System Attitude–Orbit Integration Fixed-Time Control
    MDPI AG ; 2023
    In:  Electronics Vol. 12, No. 15 ( 2023-08-03), p. 3329-
    Details
    In: Electronics, MDPI AG, Vol. 12, No. 15 ( 2023-08-03), p. 3329-
    Abstract: A diffractive imaging system consisting of two satellites is analyzed in view of dynamics. The mathematical model of rigid and flexion couples is studied to describe the relative motion of diffractive satellites and imaging satellites. Based on an integrated dynamics model with dual quaternion, a fixed-time non-singular terminal sliding mode controller is designed to meet the requirements of Earth observation. Finally, introducing the non-singular terminal sliding mode as the control group, a comparative simulation of relative motion and control is implemented to verify the controller and dynamics model.
    Type of Medium: Online Resource
    ISSN: 2079-9292
    URL: Article
    DOI: 10.3390/electronics12153329
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2662127-7
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  • 13
    Online Resource
    Online Resource
    Biomarkers for the early prediction of contrast-induced nephropathy after percutaneous coronary intervention in adults: A systematic review and meta-analysis
    SAGE Publications ; 2022
    In:  Angiology Vol. 73, No. 3 ( 2022-03), p. 207-217
    Details
    In: Angiology, SAGE Publications, Vol. 73, No. 3 ( 2022-03), p. 207-217
    Abstract: Contrast-induced nephropathy (CIN) is a complication of patients undergoing percutaneous coronary intervention (PCI). Promising biomarkers for the early prediction of CIN can significantly improve outcomes of these patients. We searched PubMed, EMBASE, Web of Science, and Cochrane Library for studies. Trials reporting an area under the curve (AUC) for the utility of novel biomarkers in the early prediction of CIN in adults after PCI were included. In total, 42 studies comprising 11,984 adult patients undergoing PCI met the criteria. Four urinary biomarkers and four blood biomarkers were included. For urine biomarkers, the pooled AUCs for neutrophil gelatinase-associated lipocalin (NGAL), interleukin-18 (IL-18), liver-type fatty acid-binding protein (L-FABP), and kidney injury molecule-1 (KIM-1) were 0.91 (95% CI 0.89–0.94), 0.79 (0.75–0.82), 0.78 (0.74–0.82), and 0.79 (0.76–0.83), respectively. The blood biomarkers NGAL, cystatin C, brain natriuretic peptide (BNP), and C-reactive protein (CRP) had pooled AUCs of 0.93 (0.91–0.95), 0.92 (0.89–0.94), 0.78 (0.74–0.81), and 0.75 (0.71–0.79), respectively. Subgroup analysis showed that blood NGAL in early CIN predictive time ( 〈 6 h) was more effective in predicting CIN. The efficiency of cystatin C in predicting CIN was reduced, whereas that of L-FABP was increased among chronic kidney disease (CKD) patients.
    Type of Medium: Online Resource
    ISSN: 0003-3197 , 1940-1574
    URL: Article
    DOI: 10.1177/00033197211039921
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2065911-8
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  • 14
    Online Resource
    Online Resource
    Optimal Mean Arterial Pressure Within 24 Hours of Admission for Patients With Intermediate-Risk and High-Risk Pulmonary Embolism
    SAGE Publications ; 2020
    In:  Clinical and Applied Thrombosis/Hemostasis Vol. 26 ( 2020-01-01), p. 107602962093394-
    Details
    In: Clinical and Applied Thrombosis/Hemostasis, SAGE Publications, Vol. 26 ( 2020-01-01), p. 107602962093394-
    Abstract: We aimed to determine whether the average mean arterial pressure (aMAP) in the first 24 hours of hospital admission is useful in predicting short-term outcomes of patients with intermediate- and high-risk pulmonary embolism (PE). We conducted a single-center retrospective study. From May 2012 to April 2019, 122 patients with intermediate- and high-risk PE were included. The primary outcome was in-hospital mortality. The secondary outcome was adverse events. Receiver operating characteristic (ROC) curves and cutoff values for aMAP predicting in-hospital death were computed. According to cutoff values, we categorized 5 groups defined as follows: group 1: aMAP 〈 70 mm Hg; group 2: 70 mm Hg ≤ aMAP 〈 80 mm Hg; group 3: 80 mm Hg ≤ aMAP 〈 90 mm Hg; group 4: 90 mm Hg ≤ aMAP 〈 100 mm Hg; and group 5: aMAP ≥ 100 mm Hg. Cox regression models were calculated to investigate associations between aMAP and in-hospital death. In the study group of 122 patients, 15 (12.30%) patients died in the hospital due to PE. The ROC analysis for MAP predicting in-hospital death revealed an area under the curve of 0.729 with a cutoff value of 79.4 mm Hg. Cox regression models showed a significant association between in-hospital death and aMAP group 1 (ref), aMAP group 2 (odds ratio [OR] = 1.680, 95% CI: 0.020-140.335), aMAP group 3 (OR = 0.003, 95% CI: 0.0001-0.343), aMAP group 4 (OR = 0.006, 95% CI: 0.0001-1.671), and aMAP group 5 (OR = 0.003, 95% CI: 0.0001-9.744). In particular, those with an aMAP of 80 to 90 mm Hg had minimum adverse events. The optimal range of MAP for patients with intermediate- and high-risk PE may be 80 to 90 mm Hg.
    Type of Medium: Online Resource
    ISSN: 1076-0296 , 1938-2723
    URL: Article
    DOI: 10.1177/1076029620933944
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2230591-9
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  • 15
    Online Resource
    Online Resource
    COVID‐19 and coagulation dysfunction in adults: A systematic review and meta‐analysis
    Wiley ; 2021
    In:  Journal of Medical Virology Vol. 93, No. 2 ( 2021-02), p. 934-944
    Details
    In: Journal of Medical Virology, Wiley, Vol. 93, No. 2 ( 2021-02), p. 934-944
    Abstract: Coagulation dysfunction affects the prognosis of COVID‐19 patients. Lower platelet, higher d‐dimer and fibrinogen indicate increased severity risk in COVID‐19 patients. No difference in PT and APTT is evident between severe and non‐severe COVID‐19 patients upon admission.
    Type of Medium: Online Resource
    ISSN: 0146-6615 , 1096-9071
    URL: Issue
    URL: Article
    DOI: 10.1002/jmv.v93.2
    DOI: 10.1002/jmv.26346
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 752392-0
    detail.hit.zdb_id: 1475090-9
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  • 16
    Online Resource
    Online Resource
    miR-34b-5p promotes renal cell inflammation and apoptosis by inhibiting aquaporin-2 in sepsis-induced acute kidney injury
    Informa UK Limited ; 2021
    In:  Renal Failure Vol. 43, No. 1 ( 2021-01-01), p. 291-301
    Details
    In: Renal Failure, Informa UK Limited, Vol. 43, No. 1 ( 2021-01-01), p. 291-301
    Type of Medium: Online Resource
    ISSN: 0886-022X , 1525-6049
    URL: Article
    DOI: 10.1080/0886022X.2021.1871922
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2015459-8
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