In:
Arhiv za bioloske nauke, National Library of Serbia, Vol. 64, No. 3 ( 2012), p. 1173-1180
Abstract:
Patients with end-stage renal disease (ESRD) include a significant percentage
of malnourished patients with other risk factors: dyslipoproteinemia, insulin
resistance, increased oxidative stress and inflammation that together impair
endothelial function. Abnormal polyunsaturated fatty acids (PUFA) patterns
are reported in patients with ESRD. The basic mechanisms of these disorders
are connected with changes in cell functions at the membrane level. Vascular
smooth muscle cell proliferation plays an important role in the pathogenesis
of atherosclerosis. We have examined the association between atherosclerotic
risk factors and nutritional status in hemodialysis (HD) patients. Mortality
was followed for up to 18 month. Forty-three HD patients were examined (20
males, 23 females, ages 55?12 years). Nutritional and inflammatory markers,
including serum concentrations of C-reactive protein (CRP), tumor necrosis
factor alpha (TNF-alpha), and interleukin 6 (IL-6), were measured. There was
significant positive correlation between the plasma albumin level and CRP.
Significant correlation was found between plasma the cholesterol level and
some PUFA. Increasing inflammation and endothelial dysfunction predict the
development of vascular disease. We report on the relationship between
inflammatory markers and nutritional parameter, indices of atherosclerosis
and other cardiovascular risk factors in patients on hemodialysis.
Type of Medium:
Online Resource
ISSN:
0354-4664
,
1821-4339
Language:
English
Publisher:
National Library of Serbia
Publication Date:
2012
detail.hit.zdb_id:
2380842-1
Permalink