In:
Current Oncology, MDPI AG, Vol. 31, No. 4 ( 2024-03-29), p. 1831-1838
Abstract:
Molecular analysis of the growing teratoma syndrome has not been extensively studied. Here, we report a 14-year-old boy with a growing mass during treatment for a mixed germ cell tumor of the pineal region. Tumor markers were negative; thus, growing teratoma syndrome was suspected. A radical resection via the occipital transtentorial approach was performed, and histopathological examination revealed a teratoma with malignant features. Methylation classifier analysis confirmed the diagnosis of teratoma, and DMRT1 loss and 12p gain were identified by copy number variation analysis, potentially elucidating the cause of growth and malignant transformation of the teratoma. The patient remains in remission after intense chemoradiation treatment as a high-risk germ cell tumor.
Type of Medium:
Online Resource
ISSN:
1718-7729
DOI:
10.3390/curroncol31040138
Language:
English
Publisher:
MDPI AG
Publication Date:
2024
detail.hit.zdb_id:
2270777-3
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