In:
Diabetes, American Diabetes Association, Vol. 39, No. 12 ( 1990-12-01), p. 1584-1586
Kurzfassung:
From days 30–120 after birth, 59 BB rats were treated with water (n = 20) or FK 506 in intragastric doses of 1 mg · kg−1 · day−1 (n = 19) or 2 mg · kg−1 day−1 (n = 20). Diabetes developed in 75,15, and 0% of the 3 groups, respectively. Animals protected from diabetes by FK 506 had normal intraperitoneal glucose tolerance tests, virtual absence histopathologically of autoimmune insulitis, and normal pancreatic insulin content. Forty-five to 75 days after stopping FK 506, ∼75% of the rats that were diabetes free at 120 days remained so.
Materialart:
Online-Ressource
ISSN:
0012-1797
,
1939-327X
DOI:
10.2337/diab.39.12.1584
Sprache:
Englisch
Verlag:
American Diabetes Association
Publikationsdatum:
1990
ZDB Id:
1501252-9
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