In:
Digestion, S. Karger AG, Vol. 86, No. 1 ( 2012), p. 20-26
Abstract:
〈 b 〉 〈 i 〉 Background/Aims: 〈 /i 〉 〈 /b 〉 Autoimmune gastritis (AIG) may predispose to gastric carcinoid tumors or adenocarcinomas and may also cause unexplained iron and/or vitamin B 〈 sub 〉 12 〈 /sub 〉 deficiency. The aims of this study were to explore clinical manifestations, endoscopic findings and laboratory features of patients with AIG. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 109 patients with AIG were enrolled into the study. In addition to demographic and clinical data, gastric lesions, serum gastrin, vitamin B 〈 sub 〉 12 〈 /sub 〉 , antiparietal cell antibody (APA), current 〈 i 〉 Helicobacter pylori 〈 /i 〉 status, and anti- 〈 i 〉 H. pylori 〈 /i 〉 IgG were also investigated. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The mean age of the patients was 53.06 ± 12.7 years (range 24–81; 72 (66.1%) women). The most common main presenting symptom was abdominal symptoms in 51 patients, consultation for iron and/or vitamin B 〈 sub 〉 12 〈 /sub 〉 deficiency in 36, and non-specific symptoms including intermittent diarrhea in 15 patients. Endoscopic lesions were detected in 17 patients, hyperplastic polyps in 8, gastric carcinoid tumor in 4, fundic gland polyps in 3, and adenomatous polyps in 2 patients. 〈 i 〉 H. pylori 〈 /i 〉 was negative in all patients in biopsy specimens; however, anti- 〈 i 〉 H. pylori 〈 /i 〉 IgG was positive in 30 (27.5%) patients. 91 patients (83.4%) were positive for APA. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 In patients with AIG, the main symptoms prompted for clinical investigation were: abdominal symptoms, iron/B 〈 sub 〉 12 〈 /sub 〉 deficiency and non-specific symptoms. 20% of patients with AIG had various gastric lesions including type I gastric carcinoids. None of the patients were positive for 〈 i 〉 H. pylori 〈 /i 〉 by means of invasive tests; however, anti- 〈 i 〉 H. pylori 〈 /i 〉 IgG was found in 27.5% of patients. Patients referring with non-specific abdominal symptoms such as bloating, diarrhea and iron/B 〈 sub 〉 12 〈 /sub 〉 deficiency should be investigated for the presence of AIG.
Type of Medium:
Online Resource
ISSN:
0012-2823
,
1421-9867
Language:
English
Publisher:
S. Karger AG
Publication Date:
2012
detail.hit.zdb_id:
1482218-0
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