In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 4 ( 2021-4-26), p. e0250491-
Abstract:
As the most common type of neurodegenerative diseases (NDDs), Alzheimer’s disease (AD) is thought to be caused mainly by the excessive aggregation of β-amyloid protein (Aβ). However, a growing number of studies have found that reactive oxygen species (ROS) play a key role in the onset and progression of AD. The present study aimed to probe the neuroprotective effect of high-frequency low-intensity pulsed electric field (H-LIPEF) for SH-SY5Y cells against hydrogen peroxide (H 2 O 2 ) and Aβ-induced cytotoxicity. By looking in a systematic way into the frequency- and amplitude-dependent neuroprotective effect of pulsed electric field (PEF), the study finds that H-LIPEF at 200 Hz produces the optimal protective effect for SH-SY5Y cells. The underlying mechanisms were confirmed to be due to the activation of extracellular signal-regulated kinase (ERK) pathway and the downstream prosurvival and antioxidant proteins. Because the electric field can be modified to focus on specific area in a non-contact manner, the study suggests that H-LIPEF holds great potential for treating NDDs, whose effect can be further augmented with the administering of drugs or natural compounds at the same time.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0250491
DOI:
10.1371/journal.pone.0250491.g001
DOI:
10.1371/journal.pone.0250491.g002
DOI:
10.1371/journal.pone.0250491.g003
DOI:
10.1371/journal.pone.0250491.g004
DOI:
10.1371/journal.pone.0250491.g005
DOI:
10.1371/journal.pone.0250491.g006
DOI:
10.1371/journal.pone.0250491.g007
DOI:
10.1371/journal.pone.0250491.g008
DOI:
10.1371/journal.pone.0250491.g009
DOI:
10.1371/journal.pone.0250491.g010
DOI:
10.1371/journal.pone.0250491.s001
DOI:
10.1371/journal.pone.0250491.s002
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
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