In:
eLife, eLife Sciences Publications, Ltd, Vol. 6 ( 2017-06-20)
Abstract:
In the arcuate nucleus of the hypothalamus (ARH) satiety signaling (anorexigenic) pro-opiomelanocortin (POMC)-expressing and hunger signaling (orexigenic) agouti-related peptide (AgRP)-expressing neurons are key components of the neuronal circuits that control food intake and energy homeostasis. Here, we assessed whether the catecholamine noradrenalin directly modulates the activity of these neurons in mice. Perforated patch clamp recordings showed that noradrenalin changes the activity of these functionally antagonistic neurons in opposite ways, increasing the activity of the orexigenic NPY/AgRP neurons and decreasing the activity of the anorexigenic POMC neurons. Cell type-specific transcriptomics and pharmacological experiments revealed that the opposing effect on these neurons is mediated by the activation of excitatory α1A - and β- adrenergic receptors in NPY/AgRP neurons, while POMC neurons are inhibited via α2A – adrenergic receptors. Thus, the coordinated differential modulation of the key hypothalamic neurons in control of energy homeostasis assigns noradrenalin an important role to promote feeding.
Type of Medium:
Online Resource
ISSN:
2050-084X
DOI:
10.7554/eLife.25770.001
DOI:
10.7554/eLife.25770.002
DOI:
10.7554/eLife.25770.003
DOI:
10.7554/eLife.25770.004
DOI:
10.7554/eLife.25770.005
DOI:
10.7554/eLife.25770.006
DOI:
10.7554/eLife.25770.007
DOI:
10.7554/eLife.25770.008
DOI:
10.7554/eLife.25770.009
DOI:
10.7554/eLife.25770.010
DOI:
10.7554/eLife.25770.011
DOI:
10.7554/eLife.25770.012
DOI:
10.7554/eLife.25770.013
DOI:
10.7554/eLife.25770.014
Language:
English
Publisher:
eLife Sciences Publications, Ltd
Publication Date:
2017
detail.hit.zdb_id:
2687154-3
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