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  • 11
    Online Resource
    Online Resource
    Potential mechanisms of quercetin in cancer prevention: focus on cellular and molecular targets
    Springer Science and Business Media LLC ; 2022
    In:  Cancer Cell International Vol. 22, No. 1 ( 2022-08-15)
    Details
    In: Cancer Cell International, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2022-08-15)
    Abstract: Over the past few years, the cancer-related disease has had a high mortality rate and incidence worldwide, despite clinical advances in cancer treatment. The drugs used for cancer therapy, have high side effects in addition to the high cost. Subsequently, to reduce these side effects, many studies have suggested the use of natural bioactive compounds. Among these, which have recently attracted the attention of many researchers, quercetin has such properties. Quercetin, a plant flavonoid found in fresh fruits, vegetables and citrus fruits, has anti-cancer properties by inhibiting tumor proliferation, invasion, and tumor metastasis. Several studies have demonstrated the anti-cancer mechanism of quercetin, and these mechanisms are controlled through several signalling pathways within the cancer cell. Pathways involved in this process include apoptotic, p53, NF-κB, MAPK, JAK/STAT, PI3K/AKT, and Wnt/β-catenin pathways. In addition to regulating these pathways, quercetin controls the activity of oncogenic and tumor suppressor ncRNAs. Therefore, in this comprehensive review, we summarized the regulation of these signalling pathways by quercetin. The modulatory role of quercetin in the expression of various miRNAs has also been discussed. Understanding the basic anti-cancer mechanisms of these herbal compounds can help prevent and manage many types of cancer.
    Type of Medium: Online Resource
    ISSN: 1475-2867
    URL: Article
    DOI: 10.1186/s12935-022-02677-w
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2091573-1
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  • 12
    Online Resource
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    Pharmacological effects and therapeutic potential of natural compounds in neuropsychiatric disorders: An update
    Frontiers Media SA ; 2022
    In:  Frontiers in Pharmacology Vol. 13 ( 2022-9-15)
    Details
    In: Frontiers in Pharmacology, Frontiers Media SA, Vol. 13 ( 2022-9-15)
    Abstract: Neuropsychiatric diseases are a group of disorders that cause significant morbidity and disability. The symptoms of psychiatric disorders include anxiety, depression, eating disorders, autism spectrum disorders (ASD), attention-deficit/hyperactivity disorder, and conduct disorder. Various medicinal plants are frequently used as therapeutics in traditional medicine in different parts of the world. Nowadays, using medicinal plants as an alternative medication has been considered due to their biological safety. Despite the wide range of medications, many patients are unable to tolerate the side effects and eventually lose their response. By considering the therapeutic advantages of medicinal plants in the case of side effects, patients may prefer to use them instead of chemical drugs. Today, the use of medicinal plants in traditional medicine is diverse and increasing, and these plants are a precious heritage for humanity. Investigation about traditional medicine continues, and several studies have indicated the basic pharmacology and clinical efficacy of herbal medicine. In this article, we discuss five of the most important and common psychiatric illnesses investigated in various studies along with conventional therapies and their pharmacological therapies. For this comprehensive review, data were obtained from electronic databases such as MedLine/PubMed, Science Direct, Web of Science, EMBASE, DynaMed Plus, ScienceDirect, and TRIP database. Preclinical pharmacology studies have confirmed that some bioactive compounds may have beneficial therapeutic effects in some common psychiatric disorders. The mechanisms of action of the analyzed biocompounds are presented in detail. The bioactive compounds analyzed in this review are promising phytochemicals for adjuvant and complementary drug candidates in the pharmacotherapy of neuropsychiatric diseases. Although comparative studies have been carefully reviewed in the preclinical pharmacology field, no clinical studies have been found to confirm the efficacy of herbal medicines compared to FDA-approved medicines for the treatment of mental disorders. Therefore, future clinical studies are needed to accelerate the potential use of natural compounds in the management of these diseases.
    Type of Medium: Online Resource
    ISSN: 1663-9812
    URL: Article
    DOI: 10.3389/fphar.2022.926607
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2587355-6
    SSG: 15,3
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  • 13
    Online Resource
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    Curcumin-Loaded Silica Nanoparticles: Applications in Infectious Disease and Food Industry
    MDPI AG ; 2022
    In:  Nanomaterials Vol. 12, No. 16 ( 2022-08-18), p. 2848-
    Details
    In: Nanomaterials, MDPI AG, Vol. 12, No. 16 ( 2022-08-18), p. 2848-
    Abstract: Curcumin has multiple properties that are used to cure different diseases such as cancer, infections, inflammatory, arthritic disease, etc. Despite having many effects, the inherent physicochemical properties—such as poor water solubility, chemical instability, low bioavailability, photodegradation, fast metabolism, and short half-life—of curcumin’s derivatives have limited its medical importance. Recently, unprecedented advances in biomedical nanotechnology have led to the development of nanomaterial-based drug delivery systems in the treatment of diseases and diagnostic goals that simultaneously enhance therapeutic outcomes and avoid side effects. Mesoporous silica nanoparticles (MSNs) are promising drug delivery systems for more effective and safer treatment of several diseases, such as infections, cancers, and osteoporosis. Achieving a high drug loading in MSNs is critical to the success of this type of treatment. Their notable inherent properties—such as adjustable size and porosity, high pore volume, large surface area, functionality of versatile surfaces, as well as biocompatibility—have prompted extraordinary research on MSNs as multi-purpose delivery platforms. In this review, we focused on curcumin-loaded silica nanoparticles and their effects on the diagnosis and treatment of infections as well as their use in food packaging.
    Type of Medium: Online Resource
    ISSN: 2079-4991
    URL: Article
    DOI: 10.3390/nano12162848
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2662255-5
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  • 14
    Online Resource
    Online Resource
    Pseudomonas sp. a Dominant Population of Bacteria in the Cold Water of Mount Sabalan Crater Lake
    Bentham Science Publishers Ltd. ; 2021
    In:  Current Biotechnology Vol. 10, No. 3 ( 2021-09), p. 210-217
    Details
    In: Current Biotechnology, Bentham Science Publishers Ltd., Vol. 10, No. 3 ( 2021-09), p. 210-217
    Abstract: Sabalan (Savalan) Lake is a stable crater lake located at the summit of Sabalan, an inactive stratovolcano and the third highest mountain of Iran. Because of cold weather conditions, the lake is frozen in most months of the year. The biodiversity of microbial flora in this area needs to be explored to find its similarity with the arctic regions’ biodiversity. Objective: The psychrophilic bacterial population of Sabalan (Savalan) Crater Lake was identified. The current research is the first report on aquatic bacterial strains isolation and characterization from Sabalan Lake. Methods: Water sample collections were cultured on four different media, and then colonies were isolated by the plating method. The phylogenetic features of the isolates were scrutinized, and finally, the phenotypic characteristics were investigated using specific culture methods. Results: The results of morphological tests indicated that most isolates were Gram-negative and rod shape, which were able to grow between ˗4 and +37 ºC. According to the phylogenetic analysis, the isolated strains belonged to Pseudomonas, Yersinia, Kocuria, and Micrococcus genera, and about 60% of the isolates belonged to the various species of Pseudomonas as a dominant genus with abounded frequency. In addition, several isolates showed 99% similarity with bacteria, which were previously isolated from Antarctic regions such as Pseudomonas antarctica and Micrococcus antarctica. Conclusion: It can be concluded that the microbial populations of cold areas are the same across geographical distances. In addition, these bacterial strains could be a primitive source of new enzymes for technological applications, such as biosurfactant production.
    Type of Medium: Online Resource
    ISSN: 2211-5501
    URL: Article
    DOI: 10.2174/2211550110666210917105655
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2021
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  • 15
    Online Resource
    Online Resource
    Prognostic Value and Biological Role of miR-126 in Breast Cancer
    Bentham Science Publishers Ltd. ; 2022
    In:  MicroRNA Vol. 11, No. 2 ( 2022-07), p. 95-103
    Details
    In: MicroRNA, Bentham Science Publishers Ltd., Vol. 11, No. 2 ( 2022-07), p. 95-103
    Abstract: In eukaryotic organisms such as humans, some noncoding single-stranded RNAs (ncRNAs) contribute to regulating the expression of some genes before and after the transcription process, which in turn controls a number of vital physiological processes, including cell proliferation, differentiation, invasion, angiogenesis, and embryonic development. miR-126 is one of these miRNAs expressed exclusively in endothelial cells such as capillaries and vessels involved in controlling angiogenesis. In recent years, the link between miRs such as miR-126 and the pathology of breast cancer has attracted the attention of many researchers. Numerous studies have shown that miR-126 may be able to suppress tumor tissue metastasis or to increase tumor metastasis through complex molecular mechanisms. There is ample clinical evidence that miR-126 can be used as a biomarker to predict and diagnose breast cancer due to the increased or decreased expression of certain genes in breast cancer tissue. In this review, we discuss the association between the growth and metastasis (tumorigenesis) of breast cancer and miR-126, as well as the relationship between current research advances in the prognosis, diagnosis, and treatment of breast cancer and miR-126.
    Type of Medium: Online Resource
    ISSN: 2211-5366
    URL: Article
    DOI: 10.2174/1876402914666220428123203
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2022
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  • 16
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    Online Resource
    Revisiting Inhibition Effects of miR-28 as a Metastasis Suppressor in Gastrointestinal Cancers
    Bentham Science Publishers Ltd. ; 2023
    In:  MicroRNA Vol. 12, No. 2 ( 2023-07), p. 131-142
    Details
    In: MicroRNA, Bentham Science Publishers Ltd., Vol. 12, No. 2 ( 2023-07), p. 131-142
    Abstract: MicroRNAs are critical epigenetic regulators that can be used as diagnostic, prognostic, and therapeutic biomarkers for the treatment of various diseases, including gastrointestinal cancers, among a variety of cellular and molecular biomarkers. MiRNAs have also shown oncogenic or tumor suppressor roles in tumor tissue and other cell types. Studies showed that the dysregulation of miR-28 is involved in cell growth and metastasis of gastrointestinal cancers. MiR-28 plays a key role in controlling the physiological processes of cancer cells including growth and proliferation, migration, invasion, apoptosis, and metastasis. Therefore, miR-28 expression patterns can be used to distinguish patient subgroups. Based on the previous studies, miR-28 expression can be a suitable biomarker to detect tu-mor size and predict histological grade metastasis. In this review, we summarize the inhibitory effects of miR-28 as a metastasis suppressor in gastrointestinal cancers. miR-28 plays a role as a tumor sup-pressor in gastrointestinal cancers by regulating cancer cell growth, cell differentiation, angiogenesis, and metastasis. As a result, using it as a prognostic, diagnostic, and therapeutic biomarker in the treatment of gastrointestinal cancers can be a way to solve the problems in this field.
    Type of Medium: Online Resource
    ISSN: 2211-5366
    URL: Article
    DOI: 10.2174/2211536612666230413125126
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
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  • 17
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    Phenotypic and phylogenetic characterization of Lactobacillus species isolated from traditional Lighvan cheese
    Springer Science and Business Media LLC ; 2021
    In:  Food Production, Processing and Nutrition Vol. 3, No. 1 ( 2021-12)
    Details
    In: Food Production, Processing and Nutrition, Springer Science and Business Media LLC, Vol. 3, No. 1 ( 2021-12)
    Abstract: Lighvan cheese (Lighvan panir) is among the most famous traditional cheese in Iran for its desired aroma and flavor. Undoubtedly, the lactic acid bacteria especially the genus Lactobacillus are the critical factors in developing the aroma, flavor, and texture in Lighvan cheese. In this study, the Lactobacillus population of the main Lighvan cheese was investigated. The Lactobacillus of the main Lighvan cheese was isolated using specific culture methods according to previously published Guidelines. Then, the phylogenetic features were investigated and the phenotypic characteristics were examined using specific culture methods. Twenty-eight Gram-positive bacterial species were identified belonged to the genus Lactobacillus. According to the same sequences as each other, three groups (A, B, and C) of isolates were categorized with a high degree of similarity to L. fermentum (100%) and L. casei group (L. casei, L. paracasei , and L. rhamnosus ) (99.0 to 100%). Random amplified polymorphic DNA (RAPD) fingerprint analysis manifested the presence of three clusters that were dominant in traditional Lighvan cheese. Cluster І was divided into 4 sub-clusters. By the result of carbohydrate fermentation pattern and 16S rRNA sequencing, isolates were identified as L. rhamnosus . The isolates in clusters II and III represented L. paracasei and L. fermentum , respectively as they were identified by 16S rRNA sequencing and fermented carbohydrate patterns. Our result indicated that the specific aroma and flavor of traditional Lighvan cheese can be related to its Lactobacillus population including L. fermentum , L. casei, L. paracasei , and L. rhamnosus. Graphical abstract
    Type of Medium: Online Resource
    ISSN: 2661-8974
    URL: Article
    DOI: 10.1186/s43014-021-00065-x
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 3006149-0
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  • 18
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    Online Resource
    Evaluation of anti-proliferative activity of Eryngium caucasicum on melanoma cancer cells
    Springer Science and Business Media LLC ; 2022
    In:  BMC Complementary Medicine and Therapies Vol. 22, No. 1 ( 2022-05-14)
    Details
    In: BMC Complementary Medicine and Therapies, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2022-05-14)
    Abstract: The genus Eryngium is a member of the Apiaceae family that has shown different pharmacological effects mainly including anti-inflammatory, analgesic, anti-cancer, hepatoprotective, and anti-oxidant. Previous research on the anti-cancer activity of Eryngium in some cancer cell lines has led us to explore the anti-proliferative activity of E. caucasicum in the B16F10 cell line. Objective In this study, the antiproliferative activity of E. caucasicum on melanoma cancer cells (B16F10) and non-cancerous cells (HFFF2) were evaluated in vitro. Methods The dried plant sample of E. caucasicum was extracted by Soxhlet apparatus with n-Hexane, dichloromethane, and methanol solvents. The effects of cytotoxicity of the extracts by the MTT method on melanoma cancer cells (B16F10) and noncancerous cells (HFFF2) was investigated for 24 and 48 hours. Then, the cytotoxicity of different fractions of the strong extract against normal and cancer cells was evaluated by this method. Annexin V/PI assay was used to study the induction apoptosis via the fractions in cancer cells. Findings According to the results of the MTT test, n-Hexane extract is the most effective extract against the B16F10 cell line and is a candidate for fractionation with VLC. Among the fractions, 40 and 60% VLC fractions of n-Hexan extract inhibited the growth of B16F10 cells at 24 and 48 hours while, these fractions at IC 50 concentration had no cytotoxic effects on normal cells. Treatment of cancer cells with effective extract caused apoptosis and necrosis and 40 and 60% more fractions induced apoptosis in these cells. Conclusion The n-Hexane extract of E. caucasicum and its 40 and 60% fractions showed the highest cytotoxic effect against the B16F10 cell line compared to other extracts and control groups. This inhibition was made through induction of apoptosis.
    Type of Medium: Online Resource
    ISSN: 2662-7671
    URL: Article
    DOI: 10.1186/s12906-022-03618-w
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 3037610-5
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