In:
Clinical Transplantation, Wiley, Vol. 29, No. 12 ( 2015-12), p. 1081-1089
Abstract:
The influence of immunosuppression on the recipients’ quality of life (QoL) is of major importance after OLT and has not yet been evaluated. Methods The impact of different immunosuppression regimens after OLT was evaluated in 275 patients using the Short Form 36 ( SF ‐36) survey. The following immunosuppressive strategies were compared: (a) CNI , (b) mTOR inhibitors, and (c) mTOR combined with CNI . All regimens were prescribed alone (mono) or in combination (+) with prednisolone and/or mycophenolate mofetil ( MMF ). Results Highest scores were evident in patients in the mTOR + group. There were significantly higher values for general health perceptions ( GH , p = 0.049), vitality ( VIT , p = 0.020), and physical component summary ( PCS , p = 0.041) when compared to CNI mono and for GH (p = 0.042) and VIT (p = 0.043), when compared to mTOR mono. Early conversion to mTOR inhibitors ( 〈 two months after OLT ) was associated with higher values for 7 of 10 scales, when compared to a late conversion ( 〉 two months after OLT ), with a statistically significant improvement for the dimension role‐emotional ( RE , p = 0.027). Discussion mTOR inhibitor‐based regimens appear to have beneficial effects on QoL after OLT , especially after an early conversion.
Type of Medium:
Online Resource
ISSN:
0902-0063
,
1399-0012
DOI:
10.1111/ctr.2015.29.issue-12
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2739458-X
detail.hit.zdb_id:
2004801-4
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