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  • 11
    Online Resource
    Online Resource
    American Physical Society (APS) ; 1974
    In:  Physical Review Letters Vol. 32, No. 22 ( 1974-6-3), p. 1231-1234
    In: Physical Review Letters, American Physical Society (APS), Vol. 32, No. 22 ( 1974-6-3), p. 1231-1234
    Type of Medium: Online Resource
    ISSN: 0031-9007
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    Language: English
    Publisher: American Physical Society (APS)
    Publication Date: 1974
    detail.hit.zdb_id: 1472655-5
    detail.hit.zdb_id: 208853-8
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  • 12
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 1987
    In:  Experimental Brain Research Vol. 67, No. 1 ( 1987-6), p. 61-69
    In: Experimental Brain Research, Springer Science and Business Media LLC, Vol. 67, No. 1 ( 1987-6), p. 61-69
    Type of Medium: Online Resource
    ISSN: 0014-4819 , 1432-1106
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    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 1987
    detail.hit.zdb_id: 1459099-2
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  • 13
    In: Annals of Oncology, Elsevier BV, Vol. 33 ( 2022-09), p. S578-
    Type of Medium: Online Resource
    ISSN: 0923-7534
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 2003498-2
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  • 14
    Online Resource
    Online Resource
    Oxford University Press (OUP) ; 2021
    In:  American Journal of Clinical Pathology Vol. 156, No. Supplement_1 ( 2021-10-28), p. S109-S109
    In: American Journal of Clinical Pathology, Oxford University Press (OUP), Vol. 156, No. Supplement_1 ( 2021-10-28), p. S109-S109
    Abstract: Uroplakin 1B (Upk1b) protein is relevant for stabilizing and strengthening epithelial cells that line the bladder. It helps to prevent urothelial cells from rupturing during bladder distension. Based on RNA expression studies Upk1b is expressed in a limited number of normal tissues. Methods/Case Report To comprehensively evaluate the potential diagnostic and prognostic utility of Upk1b expression analysis, a tissue microarray containing 15,182 samples from 127 different tumor types and subtypes and 608 samples of 76 different normal tissue types was analyzed by immunohistochemistry. Results (if a Case Study enter NA) Upk1b positivity was found in 61 (48%) different tumor types including 50 (39%) with at least one moderately positive and 39 tumor types (31%) with at least one strongly positive tumor. The highest positivity rate and the highest levels of expression was found in urothelial neoplasms (58-95%), Brenner tumors of the ovary (92%), epitheloid mesothelioma (87%), serous carcinomas of the ovary (58%) and the endometrium (53%) as well as squamous cell carcinomas of various sites of origin. Immunostaining was infrequent in lung adenocarcinoma (0%) and largely absent in colorectal (0.7%) or prostatic adenocarcinoma (1.3%). In urothelial tumors cancer, low Upk1b expression was linked to high grade and invasive tumor growth (p & lt;0.0001 each) as well as nodal metastasis (p=0.0006) but an unequivocal link to unfavorable tumor features was lacking in various other tumor entities. Conclusion In conclusion, the differential Upk1b expression in different tumor entities suggests potential diagnostic applications of Upk1b immunohistochemistry in panels for the distinction of malignant mesothelioma from adenocarcinoma of the lung, urothelial carcinoma from prostatic adenocarcinoma in the bladder, or pancreatico-biliary and gastro-esophageal from colorectal adenocarcinomas.
    Type of Medium: Online Resource
    ISSN: 0002-9173 , 1943-7722
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    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
    detail.hit.zdb_id: 2039921-2
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  • 15
    In: Biogeosciences, Copernicus GmbH, Vol. 16, No. 1 ( 2019-01-08), p. 17-32
    Abstract: Abstract. Tropical peat-draining rivers are known as potentially large sources of carbon dioxide (CO2) to the atmosphere due to the high loads of carbon they receive from surrounding soils. However, not many seasonally resolved data are available, limiting our understanding of these systems. We report the first measurements of carbon dioxide partial pressure (pCO2) in the Rajang River and Estuary, the longest river in Malaysia. The Rajang River catchment is characterized by extensive peat deposits found in the delta region, and by human impact such as logging, land use and river damming. pCO2 averaged 2540±189 µatm during the wet season and 2350±301 µatm during the dry season. Using three different parameterizations for the gas transfer velocity, calculated CO2 fluxes to the atmosphere were 1.5 (0.5–2.0) g C m−2 d−1 (mean, minimum – maximum) during the wet season and 1.7 (0.6–2.6) g C m−2 d−1 during the dry season. This is at the low end of reported values for Southeast Asian peat-draining rivers, but similar to values reported for Southeast Asian rivers that do not flow through peat deposits. In the Rajang River, peatlands probably do not contribute much to the CO2 flux due to the proximity of the peatlands to the coast, which limits the opportunity for degradation of organic C during transport. Thus, we suggest that peat coverage is, by itself, insufficient as the sole predictor of CO2 emissions from peat-draining rivers, and that other factors, like the spatial distribution of peat in the catchment and pH, also need to be considered.
    Type of Medium: Online Resource
    ISSN: 1726-4189
    Language: English
    Publisher: Copernicus GmbH
    Publication Date: 2019
    detail.hit.zdb_id: 2158181-2
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  • 16
    In: Parasites & Vectors, Springer Science and Business Media LLC, Vol. 12, No. 1 ( 2019-12)
    Abstract: Onchocerciasis is a priority neglected tropical disease targeted for elimination by 2025. The standard strategy to combat onchocerciasis is annual Community-Directed Treatment with ivermectin (CDTi). Yet, high prevalence rates and transmission persist following  〉  12 rounds in South-West Cameroon. Challenges include programme coverage, adherence to, and acceptability of ivermectin in an area of Loa loa co-endemicity. Loiasis patients harbouring heavy infections are at risk of potentially fatal serious adverse events following CDTi. Alternative strategies are therefore needed to achieve onchocerciasis elimination where CDTi effectiveness is suboptimal. Methods/design We designed an implementation study to evaluate integrating World Health Organisation-endorsed alternative strategies for the elimination of onchocerciasis, namely test-and-treat with the macrofilaricide, doxycycline (TTd), and ground larviciding for suppression of blackfly vectors with the organophosphate temephos. A community-based controlled before-after intervention study will be conducted among  〉  2000 participants in 20 intervention (Meme River Basin) and 10 control (Indian River Basin) communities. The primary outcome measure is O. volvulus prevalence at follow-up 18-months post-treatment. The study involves four inter-disciplinary components: parasitology, entomology, applied social sciences and health economics. Onchocerciasis skin infection will be diagnosed by skin biopsy and Loa loa infection will be diagnosed by parasitological examination of finger-prick blood samples. A simultaneous clinical skin disease assessment will be made. Eligible skin-snip-positive individuals will be offered directly-observed treatment for 5 weeks with 100 mg/day doxycycline. Transmission assessments of onchocerciasis in the communities will be collected post-human landing catch of the local biting blackfly vector prior to ground larviciding with temephos every week (0.3 l/m 3 ) until biting rate falls below 5/person/day. Qualitative research, including in-depth interviews and focus-group discussions will be used to assess acceptability and feasibility of the implemented alternative strategies among intervention recipients and providers. Health economics will assess the cost-effectiveness of the implemented interventions. Conclusions Using a multidisciplinary approach, we aim to assess the effectiveness of TTd, alone or in combination with ground larviciding, following a single intervention round and scrutinise the acceptability and feasibility of implementing at scale in similar hotspots of onchocerciasis infection, to accelerate onchocerciasis elimination.
    Type of Medium: Online Resource
    ISSN: 1756-3305
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2019
    detail.hit.zdb_id: 2409480-8
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  • 17
    Online Resource
    Online Resource
    Wiley ; 2017
    In:  International Journal of Cosmetic Science Vol. 39, No. 5 ( 2017-10), p. 535-542
    In: International Journal of Cosmetic Science, Wiley, Vol. 39, No. 5 ( 2017-10), p. 535-542
    Abstract: Il a été démontré que l'équol améliore la santé et la régénération de la peau grâce à ses caractéristiques antioxydantes, phytoestrogéniques et épigénétiques. Les effets d'une intervention topique sur la structure de la peau, la longueur des télomères et des marqueurs épigénétiques dans les cellules de la peau ont été analysés. Méthodes Soixante‐quatre participants ont été divisés en quatre groupes dont trois groupes ont reçu un traitement topique avec les préparations suivantes: une émulsion avec poudre d'équol (Isoflavandiol‐E‐55‐ RS ); une émulsion avec équol microencapsulé (Vesisorb Isoflavandiol‐E‐55‐ RS ) et une émulsion avec la lécithine (placebo Vesisorb). Un groupe de contrôle de 6 volontaires n'a reçu aucune intervention. Le composé actif était de l'équol‐racémate à 0,5%. Pour 58 participants, tous les échantillons ont été collectés. L'analyse structurelle, l'analyse moléculaire et des questionnaires ont été menés au début de l'étude et 8 semaines après l'intervention, deux fois par jour. Les paramètres structurels de la peau ont été analyses à l'aide du Visioscan VC 98 et du Cutometer dual MPA 580. Les analyses moléculaires des cellules épidermiques collectées par pelliculage de la peau du front comprenaient la longueur des télomères, la méthylation LINE ‐1, suivant une extraction d' ADN , une conversion au bisulphite et le qPCR ainsi que l'analyse de la courbe de dénaturation haute‐résolution. Les effets de la nutrition et des habitudes du style de vie ont été évalués avec un aliment standardisé et un questionnaire relatif au style de vie. Résultats et Discussion L'analyse de surface a démontré des améliorations significatives de la rugosité, de la texture et de la douceur de la peau après les deux interventions. La mesure au Cutometer dual MPA 580 a révélé une amélioration de la fermeté et de l'élasticité de la peau pour les deux préparations. Une diminution de l'hémi‐méthylation LINE ‐1 (n.s.) et de la longueur des télomères (sign. P 〈 0,05) a été observée dans le groupe échantillon avec l'âge. Dans les groupes traités, des télomères significativement plus longs ont été observés après l'intervention. Des recherches supplémentaires s'imposent pour savoir si les changements dans la longueur de télomères sont dus à des changements dans la régulation de la télomérase, à des interactions épigénétiques ou au renouvellement de kératinocytes. La stabilité et la disponibilité des préparations dans la peau semblent être élevées, étant donné que peu de différences significatives dans l'action entre les substances pures et encapsulées ont été observées. Conclusion Les résultats de la présente étude indiquent que l'équol possède des effets bénéfiques sur les paramètres structurels et moléculaires de la peau et encouragent des investigations supplémentaires pour décrypter l'épigénétique.
    Type of Medium: Online Resource
    ISSN: 0142-5463 , 1468-2494
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 1484465-5
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  • 18
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2022
    In:  Journal of Experimental Criminology Vol. 18, No. 4 ( 2022-12), p. 847-870
    In: Journal of Experimental Criminology, Springer Science and Business Media LLC, Vol. 18, No. 4 ( 2022-12), p. 847-870
    Type of Medium: Online Resource
    ISSN: 1573-3750 , 1572-8315
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2181946-4
    SSG: 2
    SSG: 2,1
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  • 19
    Online Resource
    Online Resource
    American Physical Society (APS) ; 2000
    In:  Physical Review A Vol. 62, No. 2 ( 2000-7-20)
    In: Physical Review A, American Physical Society (APS), Vol. 62, No. 2 ( 2000-7-20)
    Type of Medium: Online Resource
    ISSN: 1050-2947 , 1094-1622
    RVK:
    Language: English
    Publisher: American Physical Society (APS)
    Publication Date: 2000
    detail.hit.zdb_id: 2844156-4
    detail.hit.zdb_id: 1472694-4
    detail.hit.zdb_id: 209769-2
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  • 20
    Online Resource
    Online Resource
    IOP Publishing ; 1972
    In:  Nuclear Fusion Vol. 12, No. 3 ( 1972-05-01), p. 297-300
    In: Nuclear Fusion, IOP Publishing, Vol. 12, No. 3 ( 1972-05-01), p. 297-300
    Type of Medium: Online Resource
    ISSN: 0029-5515 , 1741-4326
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 1972
    detail.hit.zdb_id: 2037980-8
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