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  • 11
    In: BMC Genomics, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2021-12)
    Abstract: The accumulation of intracellular fat depots is a polygenic trait. Therefore, the extent of lipid storage in the individuals of a species covers a broad range and is determined by many genetic factors. Quantitative trait loci analysis can be used to identify those genetic differences between two strains of the same species that are responsible for the differences in a given phenotype. We used this method and complementary approaches to identify genes in the yeast Saccharomyces cerevisiae that are involved in neutral lipid storage. Results We selected two yeast strains, the laboratory strain BY4741 and the wine yeast AWRI1631, with a more than two-fold difference in neutral lipid content. After crossing, sporulation and germination, we used fluorescence activated cell sorting to isolate a subpopulation of cells with the highest neutral lipid content from the pool of segregants. Whole genome sequencing of this subpopulation and of the unsorted pool of segregants implicated several loci that are involved in lipid accumulation. Three of the identified genes, PIG1 , PHO23 and RML2 , were investigated in more detail. Deletions of these genes and the exchange of the alleles between the two parental strains confirmed that the encoded proteins contribute to neutral lipid storage in S. cerevisiae and that PIG1 , PHO23 and RML2 are the major causative genes. Backcrossing of one of the segregants with the parental strains for seven generations revealed additional regions in the genomes of both strains with potential causative genes for the high lipid accumulation phenotype. Conclusions We identified several genes that contribute to the phenotype of lipid accumulation in an allele-specific manner. Surprisingly, no allelic variations of genes with known functions in lipid metabolism were found, indicating that the level of storage lipid accumulation is determined by many cellular processes that are not directly related to lipid metabolism.
    Type of Medium: Online Resource
    ISSN: 1471-2164
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2041499-7
    SSG: 12
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  • 12
    In: Neurology, Ovid Technologies (Wolters Kluwer Health), Vol. 89, No. 9 ( 2017-08-29), p. 900-908
    Abstract: To assess the prognostic value of MOG antibodies (abs) in the differential diagnosis of acquired demyelinating syndromes (ADS). Methods: Clinical course, MRI, MOG-abs, AQP4-abs, and CSF cells and oligoclonal bands (OCB) in children with ADS and 24 months of follow-up were reviewed in this observational prospective multicenter hospital-based study. Results: Two hundred ten children with ADS were included and diagnosed with acute disseminated encephalomyelitis (ADEM) (n = 60), neuromyelitis optica spectrum disorder (NMOSD) (n = 12), clinically isolated syndrome (CIS) (n = 101), and multiple sclerosis (MS) (n = 37) after the first episode. MOG-abs were predominantly found in ADEM (57%) and less frequently in NMOSD (25%), CIS (25%), or MS (8%). Increased MOG-ab titers were associated with younger age ( p = 0.0001), diagnosis of ADEM ( p = 0.005), increased CSF cell counts ( p = 0.011), and negative OCB ( p = 0.012). At 24-month follow-up, 96 children had no further relapses. Thirty-five children developed recurrent non-MS episodes (63% MOG-, 17% AQP4-abs at onset). Seventy-nine children developed MS (4% MOG-abs at onset). Recurrent non-MS episodes were associated with high MOG-ab titers ( p = 0.0003) and older age at onset ( p = 0.024). MS was predicted by MS-like MRI ( p 〈 0.0001) and OCB ( p = 0.007). An MOG-ab cutoff titer ≥1:1,280 predicted a non-MS course with a sensitivity of 47% and a specificity of 100% and a recurrent non-MS course with a sensitivity of 46% and a specificity of 86%. Conclusions: Our results show that the presence of MOG-abs strongly depends on the age at disease onset and that high MOG-ab titers were associated with a recurrent non-MS disease course.
    Type of Medium: Online Resource
    ISSN: 0028-3878 , 1526-632X
    RVK:
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2017
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  • 13
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2023
    In:  New Generation Computing Vol. 41, No. 3 ( 2023-09), p. 697-722
    In: New Generation Computing, Springer Science and Business Media LLC, Vol. 41, No. 3 ( 2023-09), p. 697-722
    Abstract: Modern neural network architectures are becoming larger and deeper, with increasing computational resources needed for training and inference. One approach toward handling this increased resource consumption is to use structured weight matrices. By exploiting structures in weight matrices, the computational complexity for propagating information through the network can be reduced. However, choosing the right structure is not trivial, especially since there are many different matrix structures and structure classes. In this paper, we give an overview over the four main matrix structure classes, namely semiseparable matrices, matrices of low displacement rank, hierarchical matrices and products of sparse matrices. We recapitulate the definitions of each structure class, present special structure subclasses, and provide references to research papers in which the structures are used in the domain of neural networks. We present two benchmarks comparing the classes. First, we benchmark the error for approximating different test matrices. Second, we compare the prediction performance of neural networks in which the weight matrix of the last layer is replaced by structured matrices. After presenting the benchmark results, we discuss open research questions related to the use of structured matrices in neural networks and highlight future research directions.
    Type of Medium: Online Resource
    ISSN: 0288-3635 , 1882-7055
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 797870-4
    detail.hit.zdb_id: 2164639-9
    SSG: 11
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  • 14
    Online Resource
    Online Resource
    Walter de Gruyter GmbH ; 2001
    In:  Bibliotheksdienst Vol. 35, No. 3 ( 2001-01)
    In: Bibliotheksdienst, Walter de Gruyter GmbH, Vol. 35, No. 3 ( 2001-01)
    Type of Medium: Online Resource
    ISSN: 2194-9646 , 0006-1972
    RVK:
    Language: Unknown
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2001
    detail.hit.zdb_id: 1091-1
    detail.hit.zdb_id: 1465932-3
    SSG: 24,1
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