In:
Archiv der Pharmazie, Wiley, Vol. 309, No. 12 ( 1976-01), p. 959-965
Abstract:
β‐Substituted Enamines, VIII: Fused Ring Systems from 2‐Aminoheterocycles and Derivatives of α‐Chloroacetoacetic Acid Condensation reactions of α‐chloroacetoacetic ester or anilide with heterocycles having an amino function in α‐position to the ring nitrogen, e. g. 2‐aminopyridine ( 1 ), 2‐aminopyrimidine ( 6 ), 2‐aminothiazole ( 8 ), or 2‐aminobenzimidazole ( 10 ), yield fused heterocyclic systems via β‐chloro‐enamines. Elimination of hydrogen chloride leads to the imidazo‐pyridines, ‐pyrimidines and ‐thiazoles 4 , 7 , 9 , 12 , 13 and 16 , whereas the pyridopyrimidones 5 and pyrimidobenzimidazolones 11 are obtained by elimination of ethanol.
Type of Medium:
Online Resource
ISSN:
0365-6233
,
1521-4184
DOI:
10.1002/ardp.v309:12
DOI:
10.1002/ardp.19763091203
Language:
English
Publisher:
Wiley
Publication Date:
1976
detail.hit.zdb_id:
1496815-0
detail.hit.zdb_id:
6381-2
SSG:
15,3
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