In:
Angewandte Chemie International Edition, Wiley, Vol. 48, No. 12 ( 2009-03-09), p. 2148-2151
Abstract:
A cunning and dangerous plan foiled! An enzyme‐specific molecular construct exploits the overexpression of β‐lactamase in several drug‐resistant bacteria. Specific photodynamic toxicity was detected towards β‐lactam‐resistant methicillin‐resistant Staphylococcus aureus (MRSA), whereby the usual mechanism for antibiotic resistance (cleavage of the β‐lactam ring) releases the phototoxic component from the prodrug (see picture; Q=quencher). magnified image
Type of Medium:
Online Resource
ISSN:
1433-7851
,
1521-3773
DOI:
10.1002/anie.200804804
Language:
English
Publisher:
Wiley
Publication Date:
2009
detail.hit.zdb_id:
2011836-3
detail.hit.zdb_id:
123227-7
Permalink