GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 11
    Online Resource
    Online Resource
    Data_Sheet_1.DOCX
    Frontiers Media SA ; 2022
    In:  Frontiers in Psychiatry Vol. 12 ( 2022-1-25)
    Details
    In: Frontiers in Psychiatry, Frontiers Media SA, Vol. 12 ( 2022-1-25)
    Abstract: To explore differences and similarities in relationships between subcortical structure volumes and neurocognition among the four subject groups, including first-episode schizophrenia (FES), bipolar disorder (BD), major depression disorder (MDD), and healthy controls (HCs). Methods We presented findings from subcortical volumes and neurocognitive analyses of 244 subjects (109 patients with FES; 63 patients with BD, 30 patients with MDD, and 42 HCs). Using the FreeSurfer software, volumes of 16 selected subcortical structures were automatically segmented and analyzed for relationships with results from seven neurocognitive tests from the MATRICS (Measurement and Treatment Research to Improve Cognition in Schizophrenia) Cognitive Consensus Battery (MCCB). Results Larger left lateral ventricle volumes in FES and BD, reduced bilateral hippocampus and amygdala volumes in FES, and lower bilateral amygdala volumes in BD and MDD were presented compared with HCs, and both FES and BD had a lower bilateral amygdala volume than MDD; there were seven cognitive dimension, five cognitive dimension, and two cognitive dimension impairments in FES, BD, and MDD, respectively; significant relationships were found between subcortical volumes and neurocognition in FES and BD but not in MDD and HCs; besides age and years of education, some subcortical volumes can predict neurocognitive performances variance. Conclusion The different degrees of subcortical volume lessening may contribute to the differences in cognitive impairment among the three psychiatric disorders.
    Type of Medium: Online Resource
    ISSN: 1664-0640
    URL: Article
    URL: Article
    DOI: 10.3389/fpsyt.2021.747386
    DOI: 10.3389/fpsyt.2021.747386.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2564218-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 12
    Online Resource
    Online Resource
    Homocysteine levels in first-episode patients with psychiatric disorders
    Frontiers Media SA ; 2024
    In:  Frontiers in Psychiatry Vol. 15 ( 2024-5-23)
    Details
    In: Frontiers in Psychiatry, Frontiers Media SA, Vol. 15 ( 2024-5-23)
    Abstract: A high homocysteine (Hcy) level is a risk factor for schizophrenia, depression, and bipolar disorder. However, the role of hyperhomocysteinemia as either an independent factor or an auxiliary contributor to specific psychiatric symptoms or disorders remains unclear. This study aimed to examine Hcy levels in first-episode inpatients with psychotic symptoms and various psychiatric diseases to elucidate the association between Hcy levels and psychiatric disorders. This study enrolled 191 patients (aged 18–40 years) with psychiatric disorders. Seventy-five patients were diagnosed with schizophrenia, 48 with acute and transient psychotic disorders, 36 with manic episodes with psychosis, 32 with major depressive episodes with psychosis, and 56 healthy controls. Serum Hcy levels were measured using the enzyme cycle method. A Hcy concentration level of & gt; 15 μmol/L was defined as hyperhomocysteinemia. Hcy levels were significantly higher in first-episode patients with psychiatric disorders compared to healthy controls (5.99 ± 3.60 vs. 19.78 ± 16.61 vs. 15.50 ± 9.08 vs. 20.00 ± 11.33 vs. 16.22 ± 12.06, F = 12.778, P & lt; 0.001). Hcy levels were significantly higher in males with schizophrenia, acute and transient psychotic disorder, and major depressive disorder but not in mania [schizophrenia, ( t = -4.727, P & lt; 0.001); acute and transient psychotic disorders, ( t = -3.389, P = 0.001); major depressive episode with psychosis, ( t = -3.796, P & lt; 0.001); manic episodes with psychosis, ( t = -1.684, P = 0.101)]. However, serum Hcy levels were not significantly different among the psychiatric disorder groups ( F = 0.139, P = 0.968). Multivariate linear regression showed that males had an increased risk for homocysteinemia. (95% CI = 8.192–15.370, P & lt; 0.001). These results suggest that first-episode patients with psychiatric disorders have higher Hcy levels than in the general population, and men are at greater risk for psychiatric disorders. In conclusion, elevated Hcy levels may contribute to the pathogenesis of first-episode patients with psychotic symptoms.
    Type of Medium: Online Resource
    ISSN: 1664-0640
    URL: Article
    DOI: 10.3389/fpsyt.2024.1380900
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2024
    detail.hit.zdb_id: 2564218-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 13
    Online Resource
    Online Resource
    RanGAP helps regulate the lifespan of neural stem cells in Drosophila
    Wiley ; 2019
    In:  Aging Cell Vol. 18, No. 1 ( 2019-02)
    Details
    In: Aging Cell, Wiley, Vol. 18, No. 1 ( 2019-02)
    Abstract: By the end of neurogenesis in Drosophila pupal brain neuroblasts (NBs), nuclear Prospero (Pros) triggers cell cycle exit and terminates NB lifespan. Here, we reveal that in larval brain NBs, an intrinsic mechanism facilitates import and export of Pros across the nuclear envelope via a Ran‐mediated nucleocytoplasmic transport system. In rangap mutants, the export of Pros from the nucleus to cytoplasm is impaired and the nucleocytoplasmic transport of Pros becomes one‐way traffic, causing an early accumulation of Pros in the nuclei of the larval central brain NBs. This nuclear Pros retention initiates NB cell cycle exit and leads to a premature decrease of total NB numbers. Our data indicate that RanGAP plays a crucial role in this intrinsic mechanism that controls NB lifespan during neurogenesis. Our study may provide insights into understanding the lifespan of neural stem cells during neurogenesis in other organisms.
    Type of Medium: Online Resource
    ISSN: 1474-9718 , 1474-9726
    URL: Issue
    URL: Article
    URL: Article
    DOI: 10.1111/acel.2019.18.issue-1
    DOI: 10.1111/acel.12854
    DOI: 10.21203/rs.2.15158/v1
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2099130-7
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 14
    Online Resource
    Online Resource
    Relationship Between Plasma Aripiprazole and Dehydroaripiprazole Concentrations and Prolactin Levels in Chinese Children and Adolescents
    Mary Ann Liebert Inc ; 2023
    In:  Journal of Child and Adolescent Psychopharmacology Vol. 33, No. 1 ( 2023-02-01), p. 27-33
    Details
    In: Journal of Child and Adolescent Psychopharmacology, Mary Ann Liebert Inc, Vol. 33, No. 1 ( 2023-02-01), p. 27-33
    Type of Medium: Online Resource
    ISSN: 1044-5463 , 1557-8992
    URL: Article
    DOI: 10.1089/cap.2022.0068
    Language: English
    Publisher: Mary Ann Liebert Inc
    Publication Date: 2023
    detail.hit.zdb_id: 2035595-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 15
    Online Resource
    Online Resource
    Plasma total antioxidant status and cognitive impairments in first-episode drug-naïve patients with schizophrenia
    Springer Science and Business Media LLC ; 2019
    In:  Cognitive Neurodynamics Vol. 13, No. 4 ( 2019-8), p. 357-365
    Details
    In: Cognitive Neurodynamics, Springer Science and Business Media LLC, Vol. 13, No. 4 ( 2019-8), p. 357-365
    Type of Medium: Online Resource
    ISSN: 1871-4080 , 1871-4099
    URL: Article
    DOI: 10.1007/s11571-019-09530-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2019
    detail.hit.zdb_id: 2276890-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 16
    Online Resource
    Online Resource
    An Alternative Method of Endoscopic Intrasphenoidal Vidian Neurectomy
    Wiley ; 2018
    In:  OTO Open Vol. 2, No. 1 ( 2018-01)
    Details
    In: OTO Open, Wiley, Vol. 2, No. 1 ( 2018-01)
    Abstract: To develop an easy surgical approach to facilitate clinical management. Study Design A novel transnasal endoscopic 3‐step surgical method for vidian neurectomy was designed and tried in 91 cases with a mild‐to‐severe degree of allergic and nonallergic rhinitis refractory to routine medical therapy. Setting Endoscopic vidian neurectomy requires accurate localization of the vidian canal. However, it is not easy to localize during surgery because of its deep location and the complex anatomy of the pterygopalatine fossa. Subjects and Methods This technique consists of 3 steps, including transnasal endoscopic perforation of the anterior wall of the sphenoidal sinus as the first step and removal of the anterior wall until the exposure of the vidian canal in the junction between the anterior wall and the floor of the sphenoid sinus as the second step. The last step is the accurate resection and cauterization of the vidian nerve. In some cases in which the sphenoid sinus developed well with a big lateral space, an extended procedure of posterior ethmoidectomy was included to allow good exposure of the vidian canal. Results Using this technique, successful endoscopic vidian neurectomy in this series of patients was confirmed by both histology and Schirmer test, showing its distinct advantages of easy localization of the vidian canal and less risk of injury to the nerve and vessel bundles within the pterygopalatine fossa. Conclusion Taken together, this novel 3‐step procedure of endoscopic vidian neurectomy plus an extended procedure guarantees good exposure of the vidian canal and therefore accurate vidian neurectomy.
    Type of Medium: Online Resource
    ISSN: 2473-974X , 2473-974X
    URL: Article
    DOI: 10.1177/2473974X18764862
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2898361-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 17
    Online Resource
    Online Resource
    Anti-Inflammatory ent-Kaurane Diterpenoids from Isodon serra
    American Chemical Society (ACS) ; 2020
    In:  Journal of Natural Products Vol. 83, No. 10 ( 2020-10-23), p. 2844-2853
    Details
    In: Journal of Natural Products, American Chemical Society (ACS), Vol. 83, No. 10 ( 2020-10-23), p. 2844-2853
    Type of Medium: Online Resource
    ISSN: 0163-3864 , 1520-6025
    URL: Article
    URL: Article
    DOI: 10.1021/acs.jnatprod.9b01281
    DOI: 10.1021/acs.jnatprod.9b01281.s001
    RVK:
    WA 15000
    Language: English
    Publisher: American Chemical Society (ACS)
    Publication Date: 2020
    detail.hit.zdb_id: 1491522-4
    SSG: 12
    SSG: 15,3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 18
    Online Resource
    Online Resource
    Suicidal ideation, suicide attempts, and neurocognitive dysfunctions among patients with first‐episode schizophrenia
    Wiley ; 2020
    In:  Suicide and Life-Threatening Behavior Vol. 50, No. 6 ( 2020-12), p. 1181-1188
    Details
    In: Suicide and Life-Threatening Behavior, Wiley, Vol. 50, No. 6 ( 2020-12), p. 1181-1188
    Abstract: To determine whether suicidal ideation or suicide attempts are linked to poor neurocognitive function among individuals with first‐episode schizophrenia (FES). Method We performed a cross‐sectional study on 159 Chinese inpatients ( M age  = 27.1 years; 52.2% females) with minimal‐treated FES and collected their suicidal history through interviews and medical records. Neurocognitive performance, psychopathology, and depressive symptoms were assessed using the MATRICS Consensus Cognitive Battery, the Positive and Negative Syndrome Scale, and the Calgary Depression Scale for Schizophrenia, respectively. Results Approximately 1/10 FES inpatients had any suicide attempts, and more than 1/4 reported lifetime suicidal ideation. Inpatients with a suicide attempt or suicidal ideation scored significantly worse in the overall seven neurocognitive domains compared with those without past suicidal ideation or a suicide attempt. Linear regression suggested that suicide attempts were mainly associated with lower scores in working memory and speed of processing, after adjusting for education levels. The associations remained robust after further controlling for psychopathological and depressive symptoms. Conclusion First‐episode schizophrenia patients with suicide attempts had more severely impaired neurocognitive performances in specific domains. Fundamental neurocognitive dysfunctions should be assessed, detected, and treated after their suicide risk assessments.
    Type of Medium: Online Resource
    ISSN: 0363-0234 , 1943-278X
    URL: Issue
    URL: Article
    DOI: 10.1111/sltb.v50.6
    DOI: 10.1111/sltb.12689
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2045937-3
    SSG: 2,1
    SSG: 5,2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 19
    Online Resource
    Online Resource
    Table_1.XLS
    Frontiers Media SA ; 2021
    In:  Frontiers in Psychiatry Vol. 12 ( 2021-5-21)
    Details
    In: Frontiers in Psychiatry, Frontiers Media SA, Vol. 12 ( 2021-5-21)
    Abstract: The microbiota–gut–brain axis plays a critical role in the pathogenesis of major depressive disorder (MDD) and related subclinical symptoms. However, studies on the gut microbiota in MDD are inconsistent, and data on MDD's effects on sleep are lacking. This study aimed to analyze the gut microbiota composition and sleep quality of patients with MDD. We performed 16S rRNA sequencing of stool samples from 36 patients with MDD and 45 healthy controls (HC). Sleep quality was assessed using the Pittsburgh Sleep Quality Index, depressive severity with the Hamilton Depression Scale, and insomnia severity using the Insomnia Severity Index. Forty-eight microbiota targets showed significant differences between MDD and HC. In MDD, six microbiota targets were associated with the severity of depression, 11 with sleep quality, and 3 with sleep severity. At the genus level, Dorea was simultaneously related to depression and sleep quality, while Intestinibacter was more closely related to sleep problems. Coprococcus and Intestinibacter were associated with sleep quality independent of the severity of depression. In conclusion, the present findings enable a better understanding of the relationship between gut microbiota and MDD-related symptoms. Gut microbiota alterations may become potential biomarkers and/or treatment targets for sleep quality in MDD.
    Type of Medium: Online Resource
    ISSN: 1664-0640
    URL: Article
    URL: Article
    DOI: 10.3389/fpsyt.2021.645045
    DOI: 10.3389/fpsyt.2021.645045.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2564218-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 20
    Online Resource
    Online Resource
    Effects of smoking cessation on plasma clozapine concentrations in male patients with schizophrenia during the COVID-19 pandemic
    Frontiers Media SA ; 2023
    In:  Frontiers in Psychiatry Vol. 14 ( 2023-9-15)
    Details
    In: Frontiers in Psychiatry, Frontiers Media SA, Vol. 14 ( 2023-9-15)
    Abstract: This study aimed to investigate the effect of smoking cessation on plasma clozapine (CLO) concentrations in long-term hospitalized Chinese male patients with schizophrenia treated with CLO during the COVID-19 pandemic. Methods Therapeutic drug monitoring (TDM) data for CLO were collected at Beijing HuiLongGuan Hospital between December 1, 2019 (before smoking cessation) and January 31, 2020 (after smoking cessation) in this retrospective study. Fifty-three male smokers and inpatients with schizophrenia who were treated with CLO were included. Plasma concentrations of CLO were measured using high-performance liquid chromatography–tandem mass spectrometry. The fagerstrom test for nicotine dependence (FTND) was used to assess smoking behavior. Results The plasma CLO concentrations and dose-corrected plasma CLO concentrations were significantly increased by 29.3 and 23.5%, respectively, after smoking cessation. Discussion The results suggested that clinicians and pharmacists should adjust the CLO dose based on changes in smoking status in patients stabilized with CLO during the COVID-19 pandemic. Careful TDM for CLO should be performed prior to dose adjustment，to reduce the increased risk of smoking cessation induced side effects, especially for older patients receiving multiple medications.
    Type of Medium: Online Resource
    ISSN: 1664-0640
    URL: Article
    DOI: 10.3389/fpsyt.2023.1256264
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2564218-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...