In:
Journal of Endotoxin Research, SAGE Publications, Vol. 7, No. 6 ( 2001-12), p. 421-429
Kurzfassung:
The clearance and activity of different types of lipopolysaccharide (LPS) released during infection with Gram-negative bacteria were investigated. When highly purified preparations differing in their specific endotoxin activity were administered intravenously to mice, the clearance of rough (R)-form LPS preparations from Salmonella minnesota and Escherichia coli was much faster than that of a smooth (S)-form LPS preparation from Salmonella abortus equi, but slower than that of lipooligosaccharides (LOS) preparations from Bordetella pertussis and Helicobacter pylori. After intraperitoneal infection with 10 7 and 10 8 CFU E. coli O111:B4, relatively high levels of LPS were detected dose-dependently in the plasma of infected mice and persisted for a long time. In addition, plasma sCD14 levels in infected mice were higher than in LPS-administered mice. These results indicate that continuously higher levels of plasma LPS followed by stronger host responses occur during infection and suggest that these differences between LPS-administered and infected mice should be taken into consideration when analyzing host responses induced by LPS.
Materialart:
Online-Ressource
ISSN:
0968-0519
DOI:
10.1177/09680519010070060501
Sprache:
Englisch
Verlag:
SAGE Publications
Publikationsdatum:
2001
ZDB Id:
2381250-3
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