In:
American Journal of Physiology-Gastrointestinal and Liver Physiology, American Physiological Society, Vol. 296, No. 4 ( 2009-04), p. G735-G739
Kurzfassung:
The incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), play an important role in glucose homeostasis in both health and diabetes. In mice, sucralose, an artificial sweetener, stimulates GLP-1 release via sweet taste receptors on enteroendocrine cells. We studied blood glucose, plasma levels of insulin, GLP-1, and GIP, and gastric emptying (by a breath test) in 7 healthy humans after intragastric infusions of 1) 50 g sucrose in water to a total volume of 500 ml (∼290 mosmol/l), 2) 80 mg sucralose in 500 ml normal saline (∼300 mosmol/l, 0.4 mM sucralose), 3) 800 mg sucralose in 500 ml normal saline (∼300 mosmol/l, 4 mM sucralose), and 4) 500 ml normal saline (∼300 mosmol/l), all labeled with 150 mg 13 C-acetate. Blood glucose increased only in response to sucrose ( P 〈 0.05). GLP-1, GIP, and insulin also increased after sucrose ( P = 0.0001) but not after either load of sucralose or saline. Gastric emptying of sucrose was slower than that of saline ( t 50 : 87.4 ± 4.1 min vs. 74.7 ± 3.2 min, P 〈 0.005), whereas there were no differences in t 50 between sucralose 0.4 mM (73.7 ± 3.1 min) or 4 mM (76.7 ± 3.1 min) and saline. We conclude that sucralose, delivered by intragastric infusion, does not stimulate insulin, GLP-1, or GIP release or slow gastric emptying in healthy humans.
Materialart:
Online-Ressource
ISSN:
0193-1857
,
1522-1547
DOI:
10.1152/ajpgi.90708.2008
Sprache:
Englisch
Verlag:
American Physiological Society
Publikationsdatum:
2009
ZDB Id:
1477329-6
SSG:
12
Permalink