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  • 1
    Online Resource
    Online Resource
    American Geophysical Union (AGU) ; 2021
    In:  Geophysical Research Letters Vol. 48, No. 19 ( 2021-10-16)
    In: Geophysical Research Letters, American Geophysical Union (AGU), Vol. 48, No. 19 ( 2021-10-16)
    Abstract: Thermal wind shear in the bottom boundary layer reduces the magnitude of the near‐bottom flow and bottom stress Accounting for boundary layer shear reduces kinetic energy loss from the geostrophically balanced flow by more than 50% Observations and models that do not resolve the bottom boundary layer will overestimate the energy dissipation due to bottom drag
    Type of Medium: Online Resource
    ISSN: 0094-8276 , 1944-8007
    Language: English
    Publisher: American Geophysical Union (AGU)
    Publication Date: 2021
    detail.hit.zdb_id: 2021599-X
    detail.hit.zdb_id: 7403-2
    SSG: 16,13
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  • 2
    In: Metabolic Engineering, Elsevier BV, Vol. 77 ( 2023-05), p. 273-282
    Type of Medium: Online Resource
    ISSN: 1096-7176
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 1471017-1
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2017
    In:  Nature Geoscience Vol. 10, No. 11 ( 2017-11), p. 840-845
    In: Nature Geoscience, Springer Science and Business Media LLC, Vol. 10, No. 11 ( 2017-11), p. 840-845
    Type of Medium: Online Resource
    ISSN: 1752-0894 , 1752-0908
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2017
    detail.hit.zdb_id: 2396648-8
    detail.hit.zdb_id: 2405323-5
    SSG: 16,13
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  • 4
    Online Resource
    Online Resource
    Wiley ; 2019
    In:  The FEBS Journal Vol. 286, No. 14 ( 2019-07), p. 2737-2752
    In: The FEBS Journal, Wiley, Vol. 286, No. 14 ( 2019-07), p. 2737-2752
    Abstract: Lung cancer is a malignancy with one of the highest incidence rates, and it is the leading cause of cancer‐related death. To gain further insights into the underlying mechanisms of tumor growth and metastasis, we investigated the role and expression of microRNAs in lung adenocarcinoma (LUAD). We discovered a significantly lower expression level of microRNA‐520c‐3p (miR‐520c‐3p) in LUAD tissues than in nontumor tissues. miR‐520c‐3p is known to regulate multiple biological functions and cellular behaviors. In this study, we show that AKT1 and AKT2 are key direct targets of miR‐520c‐3p, which are required for its biological roles in LUAD. Mechanistically, downregulation of miR‐520c‐3p in LUAD is due to DNA methylation of the miR‐520c‐3p promoter region. Conversely, the activity of the transcription factor Yin Yang 1 (YY1) results in the upregulation of miR‐520c‐3p. Taken together, our results reveal methylation/YY1/miR‐520c‐3p/AKT1/AKT2 as a molecular axis with a potent biological function and highlight miR‐520c‐3p as a novel potent tumor suppressor in LUAD.
    Type of Medium: Online Resource
    ISSN: 1742-464X , 1742-4658
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2172518-4
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    MDPI AG ; 2022
    In:  Fluids Vol. 7, No. 2 ( 2022-02-18), p. 82-
    In: Fluids, MDPI AG, Vol. 7, No. 2 ( 2022-02-18), p. 82-
    Abstract: The dissipation of the kinetic energy (KE) associated with oceanic flows is believed to occur primarily in the oceanic bottom boundary layer (BBL), where bottom drag converts the KE from mean flows to heat loss through irreversible mixing at molecular scales. Due to the practical difficulties associated with direct observations on small-scale turbulence close to the seafloor, most up-to-date estimates on bottom drag rely on a simple bulk formula (CdU3) proposed by G.I. Taylor that relates the integrated BBL dissipation rate to a drag coefficient (Cd) as well as a flow magnitude outside of the BBL (U). Using output from several turbulence-resolving direct numerical simulations, it is shown that the true BBL-integrated dissipation rate is approximately 90% of that estimated using the classic bulk formula, applied here to the simplest scenario where a mean flow is present over a flat and hydrodynamically smooth bottom. It is further argued that Taylor’s formula only provides an upper bound estimate and should be applied with caution in the future quantification of BBL dissipation; the performance of the bulk formula depends on the distribution of velocity and shear stress near the bottom, which, in the real ocean, could be disrupted by bottom roughness.
    Type of Medium: Online Resource
    ISSN: 2311-5521
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2882362-X
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  • 6
    Online Resource
    Online Resource
    Cambridge University Press (CUP) ; 2018
    In:  Journal of Glaciology Vol. 64, No. 246 ( 2018-08), p. 661-668
    In: Journal of Glaciology, Cambridge University Press (CUP), Vol. 64, No. 246 ( 2018-08), p. 661-668
    Abstract: Meltwater is important to understanding glacier health and dynamics. Since melt measurements are uncommon, ice ablation estimates are often based on models including the positive degree day (PDD) model. The PDD estimate is popular since it only requires air temperature as input, but suffers from the lack of physical motivation of an energy-balance model. We present a physics-based alternative to the PDD model that still only takes air/surface temperature as input. The model resembles the PDD model except accounting for time lags in ablation when cold ice needs to be warmed. The model is expressed as a differential equation with a single extra parameter related to the efficiency of heating a near-surface layer of ice. With zero thickness, the model reduces to the PDD model, providing a physical basis for the PDD model. Applying the model to data from Greenland, it improves modestly upon the PDD model, with the main improvement being better prediction of early season melting. This new model is a useful compromise, with some of the physics of more realistic models and the simplicity of a PDD model. The model should improve estimates of meltwater production and help constrain PDD parameters when empirical calibration is challenging.
    Type of Medium: Online Resource
    ISSN: 0022-1430 , 1727-5652
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2018
    detail.hit.zdb_id: 2140541-4
    SSG: 14
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  • 7
    Online Resource
    Online Resource
    American Meteorological Society ; 2021
    In:  Journal of Physical Oceanography Vol. 51, No. 4 ( 2021-04), p. 1077-1089
    In: Journal of Physical Oceanography, American Meteorological Society, Vol. 51, No. 4 ( 2021-04), p. 1077-1089
    Abstract: The influence of a sloping bottom and stratification on the evolution of an oceanic bottom boundary layer (BBL) in the presence of a mean flow is explored. As a complement to an earlier study by Ruan et al. ( https://doi.org/10.1175/JPO-D-18-0079.1 ) examining Ekman arrest in a downslope regime, this paper describes turbulence and BBL dynamics during Ekman arrest in the upslope regime. In the upslope regime, an enhanced stratification develops in response to the upslope Ekman transport and suppresses turbulence. Using a suite of large-eddy simulations, we show that the BBL evolution can be described in a self-similar framework based on a nondimensional number X / X a . This nondimensional number is defined as the ratio between the lateral displacement of density surfaces across the slope X and a displacement X a required for Ekman arrest; the latter can be predicted from external parameters. Additionally, the evolution of the depth-integrated potential vorticity is considered in both upslope and downslope regimes. The PV destruction rate in the downslope regime is found to be twice the production rate in the upslope regime, using the same definition for the bottom mixed layer thickness. It is shown that this asymmetry is associated with the depth scale over which turbulent stresses are active. These results are a step toward improving parameterizations of BBL properties and evolution over sloping topography in coarse-resolution ocean models.
    Type of Medium: Online Resource
    ISSN: 0022-3670 , 1520-0485
    Language: Unknown
    Publisher: American Meteorological Society
    Publication Date: 2021
    detail.hit.zdb_id: 2042184-9
    detail.hit.zdb_id: 184162-2
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  • 8
    Online Resource
    Online Resource
    American Meteorological Society ; 2016
    In:  Journal of Physical Oceanography Vol. 46, No. 11 ( 2016-11), p. 3509-3526
    In: Journal of Physical Oceanography, American Meteorological Society, Vol. 46, No. 11 ( 2016-11), p. 3509-3526
    Abstract: Oceanic boundary currents over the continental slope exhibit variability with a range of time scales. Numerical studies of steady, along-slope currents over a sloping bathymetry have shown that cross-slope Ekman transport can advect buoyancy surfaces in a bottom boundary layer (BBL) so as to produce vertically sheared geostrophic flows that bring the total flow to rest: a process known as buoyancy shutdown of Ekman transport or Ekman arrest. This study considers the generation and evolution of near-bottom flows due to a barotropic, oscillating, and laterally sheared flow over a slope. The sensitivity of the boundary circulation to changes in oscillation frequency ω , background flow amplitude, bottom slope, and background stratification is explored. When ω / f ≪ 1, where f is the Coriolis frequency, oscillations allow the system to escape from the steady buoyancy shutdown scenario. The BBL is responsible for generating a secondary overturning circulation that produces vertical velocities that, combined with the potential vorticity (PV) anomalies of the imposed barotropic flow, give rise to a time-mean, rectified, vertical eddy PV flux into the ocean interior: a “PV pump.” In these idealized simulations, the PV anomalies in the BBL make a secondary contribution to the time-averaged PV flux. Numerical results show the domain-averaged eddy PV flux increases nonlinearly with ω with a peak near the inertial frequency, followed by a sharp decay for ω / f 〉 1. Different physical mechanisms are discussed that could give rise to the temporal variability of boundary currents.
    Type of Medium: Online Resource
    ISSN: 0022-3670 , 1520-0485
    Language: Unknown
    Publisher: American Meteorological Society
    Publication Date: 2016
    detail.hit.zdb_id: 2042184-9
    detail.hit.zdb_id: 184162-2
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  • 9
    Online Resource
    Online Resource
    American Meteorological Society ; 2022
    In:  Journal of Physical Oceanography ( 2022-08-22)
    In: Journal of Physical Oceanography, American Meteorological Society, ( 2022-08-22)
    Abstract: Small-scale mixing drives the diabatic upwelling that closes the abyssal ocean overturning circulation. Indirect microstructure measurements of in-situ turbulence suggest that mixing is bottom-enhanced over rough topography, implying downwelling in the interior and stronger upwelling in a sloping bottom boundary layer. Tracer Release Experiments (TREs), in which inert tracers are purposefully released and their dispersion is surveyed over time, have been used to independently infer turbulent diffusivities—but typically provide estimates in excess of microstructure ones. In an attempt to reconcile these differences, Ruan and Ferrari (2021) derived exact tracer-weighted buoyancy moment diagnostics, which we here apply to quasi-realistic simulations. A tracer’s diapycnal displacement rate is exactly twice the tracer-averaged buoyancy velocity, itself a convolution of an asymmetric upwelling/downwelling dipole. The tracer’s diapycnal spreading rate, however, involves both the expected positive contribution from the tracer-averaged in-situ diffusion as well as an additional non-linear diapycnal distortion term, which is caused by correlations between buoyancy and the buoyancy velocity, and can be of either sign. Distortion is generally positive (stretching) due to bottom-enhanced mixing in the stratified interior but negative (contraction) near the bottom. Our simulations suggest that these two effects coincidentally cancel for the Brazil Basin Tracer Release Experiment, resulting in negligible net distortion. By contrast, near-bottom tracers experience leading-order distortion that varies in time. Errors in tracer moments due to realistically sparse sampling are generally small ( 〈 20%), especially compared to the O (1) structural errors due to the omission of distortion effects in inverse models. These results suggest that TREs, although indispensable, should not be treated as “unambiguous” constraints on diapycnal mixing.
    Type of Medium: Online Resource
    ISSN: 0022-3670 , 1520-0485
    Language: Unknown
    Publisher: American Meteorological Society
    Publication Date: 2022
    detail.hit.zdb_id: 2042184-9
    detail.hit.zdb_id: 184162-2
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  • 10
    Online Resource
    Online Resource
    American Meteorological Society ; 2021
    In:  Journal of Physical Oceanography Vol. 51, No. 3 ( 2021-03), p. 757-767
    In: Journal of Physical Oceanography, American Meteorological Society, Vol. 51, No. 3 ( 2021-03), p. 757-767
    Abstract: Turbulent mixing across density surfaces transforms abyssal ocean waters into lighter waters and is vital to close the deepest branches of the global overturning circulation. Over the last 20 years, mixing rates inferred from in situ microstructure profilers and tracer release experiments (TREs) have provided valuable insights in the connection between small-scale mixing and large-scale ocean circulation. Problematically, estimates based on TREs consistently exceed those from collocated in situ microstructure measurements. These differences have been attributed to a low bias in the microstructure estimates that can miss strong, but rare, mixing events. Here we demonstrate that TRE estimates can suffer from a high bias, because of the approximations generally made to interpret the data. We first derive formulas to estimate mixing from the temporal growth of the second moment of a tracer patch by extending Taylor’s celebrated formula to account for both density stratification and variations in mixing rates. The formulas are validated with tracers released in numerical simulations of turbulent flows and then used to discuss biases in the interpretation of TREs based estimates and how to possibly overcome them.
    Type of Medium: Online Resource
    ISSN: 0022-3670 , 1520-0485
    Language: Unknown
    Publisher: American Meteorological Society
    Publication Date: 2021
    detail.hit.zdb_id: 2042184-9
    detail.hit.zdb_id: 184162-2
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