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  • 1
    In: Frontiers in Marine Science, Frontiers Media SA, Vol. 8 ( 2021-9-28)
    Abstract: From 2008 to 2019, a comprehensive research project, ‘SFB 754, Climate – Biogeochemistry Interactions in the Tropical Ocean,’ was funded by the German Research Foundation to investigate the climate-biogeochemistry interactions in the tropical ocean with a particular emphasis on the processes determining the oxygen distribution. During three 4-year long funding phases, a consortium of more than 150 scientists conducted or participated in 34 major research cruises and collected a wealth of physical, biological, chemical, and meteorological data. A common data policy agreed upon at the initiation of the project provided the basis for the open publication of all data. Here we provide an inventory of this unique data set and briefly summarize the various data acquisition and processing methods used.
    Type of Medium: Online Resource
    ISSN: 2296-7745
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2757748-X
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  • 2
    In: Pregnancy Hypertension, Elsevier BV, Vol. 12 ( 2018-04), p. 65-70
    Type of Medium: Online Resource
    ISSN: 2210-7789
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2018
    detail.hit.zdb_id: 2584464-7
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  • 3
    Online Resource
    Online Resource
    MDPI AG ; 2023
    In:  Metabolites Vol. 13, No. 8 ( 2023-08-15), p. 950-
    In: Metabolites, MDPI AG, Vol. 13, No. 8 ( 2023-08-15), p. 950-
    Abstract: This review analyzed 21 scientific papers on the determination of amino acids in various types of cancer in saliva. Most of the studies are on oral cancer (8/21), breast cancer (4/21), gastric cancer (3/21), lung cancer (2/21), glioblastoma (2/21) and one study on colorectal, pancreatic, thyroid and liver cancer. The amino acids alanine, valine, phenylalanine, leucine and isoleucine play a leading role in the diagnosis of cancer via the saliva. In an independent version, amino acids are rarely used; the authors combine either amino acids with each other or with other metabolites, which makes it possible to obtain high values of sensitivity and specificity. Nevertheless, a logical and complete substantiation of the changes in saliva occurring in cancer, including changes in salivary amino acid levels, has not yet been formed, which makes it important to continue research in this direction.
    Type of Medium: Online Resource
    ISSN: 2218-1989
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2662251-8
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  • 4
    In: Archives of Gerontology and Geriatrics, Elsevier BV, Vol. 80 ( 2019-01), p. 76-81
    Type of Medium: Online Resource
    ISSN: 0167-4943
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2019
    detail.hit.zdb_id: 2024857-X
    SSG: 5,2
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  • 5
    In: PULMONOLOGIYA, Scientific and Practical Reviewed Journal Pulmonology, Vol. 31, No. 6 ( 2021-12-15), p. 710-717
    Abstract: Aim. To assess the effectiveness of medical rehabilitation after pneumonia associated with the novel coronavirus infection (COVID-19), based on the study of functional capacity of the cardiovascular system and the external respiratory system. Methods. The study included 70 patients who had COVID-19 pneumonia and underwent a medical rehabilitation program from September to December 2020. Before being included in the rehabilitation program, all patients underwent pulmonary function tests (PFT), including an assessment of the lungs diffusion capacity, cardiopulmonary exercise testing, multispiral computed tomography (MSCT) of the chest, echocardiography, an evaluation of the quality of life according to the SF-36 questionnaire and the severity of shortness of breath on the mMRC scale. The effectiveness of rehabilitation was evaluated against the changes in PFT parameters, exercise tolerance, and quality of life. Results. At the enrollment, 46% of patients retained lung tissue lesions shown by MSCT and accompanied by a decrease in the lung diffusion capacity (67 (55 - 79%) of predicted value), dyspnea of 1.6 (1.0 - 3.0) points according to mMRC scale, moderate level of exercise tolerance and quality of life. Complex cardiopulmonary rehabilitation for 12 - 14 days in a specialized hospital led to a significant improvement in the parameters of pulmonary gas exchange and ventilation, peak oxygen consumption, and an increase in the reserve capacity of the cardiorespiratory system. The factors limiting the improvement of pulmonary gas exchange were the older age of the patients and the increased pressure in the pulmonary artery system. The positive influence of rehabilitation on both the physical and psycho-emotional components of the quality of life was noted. Conclusion. Complex cardiopulmonary rehabilitation with the assessment of changes in the oxygen metabolism parameters and functional capacity of the cardiovascular and respiratory systems has shown to be safe and highly effective in the studied group of patients who have had COVID-19 pneumonia.
    Type of Medium: Online Resource
    ISSN: 2541-9617 , 0869-0189
    Language: Unknown
    Publisher: Scientific and Practical Reviewed Journal Pulmonology
    Publication Date: 2021
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  • 6
    Online Resource
    Online Resource
    Moscow University for Industry and Finance - Synergy ; 2023
    In:  Journal of Modern Competition Vol. 17, No. 3 ( 2023-06-30), p. 101-114
    In: Journal of Modern Competition, Moscow University for Industry and Finance - Synergy, Vol. 17, No. 3 ( 2023-06-30), p. 101-114
    Abstract: The problem of studying the space of states in modeling socio-economic systems is considered, the basis of which is the concept of “movable equilibrium”, introduced for the first time by A. A. Bogdanov. It is proposed to apply the laws of systems theory for studying the problem of managing the state of movable equilibrium in society. The article was initiated by an important result obtained by G. B. Kleiner on the basis of understanding the ideas of A. A. Bogdanov, published in the issue 2 of the “Journal of Modern Competition” of 2023, in which the concept of A. A. Bogdanov’s space as a union of the spaces of Aristotle, I. Newton, A. Einstein and V. I. Vernadsky was proposed, which made it possible to substantiate the features of the space of A. A. Bogdanov, to connect the types of spaces with sections of the economy and to obtain a model that determines the functions of the basic subsystems of the complex (tetrad) from the object, environment, process and design component in the economic space. This important result prompted the authors to rethink the works in the field of understanding and application of the concept of “space”, since the problem of determining the state space arises in the formulation of almost any problem, especially in complicated systems. This article provides a brief analysis of the fundamental features of the definition of space in the works of different periods of the development of science. The concept of “state of movable equilibrium”, introduced by A. A. Bogdanov and studied by L. von Bertalanffy, is characterized. The article discusses the ideas of searching for forms and methods of explaining and implementing the state of movable equilibrium in A. A. Bogdanov’s “Tectology”, in his articles and science fiction novels, searching for a type of social system, a way of managing society and the state based on ensuring social justice, “on consciously comradely beginnings” according to A. A. Bogdanov, through the necessary transformation of man and society. Based on the ideas of A. A. Bogdanov on the need to create a society in which the relationship of people to nature and to each other is determined by the norms of scientific expediency, the article proposes the idea of using the laws of systems theory to study the problem of controling the state of movable equilibrium in society, and provides examples of research demonstrating the usefulness of this idea. It is concluded that in the context of the introduction of innovative technologies and artificial intelligence systems, it is becoming increasingly clear that knowledge of the features and patterns of the life of open systems with active elements is necessary not only for those who are directly involved in the management of enterprises and organizations, or those who are introducing innovative technologies, but it is necessary to everyone who will live in new difficult conditions, which, based on the research of A. A. Bogdanov and L. von Bertalanffy can be called a state of movable equilibrium.
    Type of Medium: Online Resource
    ISSN: 1993-7598 , 2687-0657
    Uniform Title: Состояние «подвижного равновесия» (по А. А. Богданову) как объект управления
    URL: Issue
    Language: Unknown
    Publisher: Moscow University for Industry and Finance - Synergy
    Publication Date: 2023
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  • 7
    Online Resource
    Online Resource
    IOP Publishing ; 2020
    In:  IOP Conference Series: Materials Science and Engineering Vol. 940, No. 1 ( 2020-09-01), p. 012009-
    In: IOP Conference Series: Materials Science and Engineering, IOP Publishing, Vol. 940, No. 1 ( 2020-09-01), p. 012009-
    Abstract: The paper considers the sustainability of the digital and industrial technologies interaction. Based on the analysis of existing studies on the introduction of innovative digital technologies and cyber-physical systems, it was realized that in the conditions of intelligent technologies joint implementation unstable states of the system are inevitable, and continuously monitoring of the system sustainability is essential. The expediency of applying the laws of the theory of open systems proposed by L. von Bertalanffy, A. Hall, and others to substantiate the managing sustainability appropriateness of the enterprise cyber-physical system is given. The quantitative estimates based on the information approach of A.A. Denisov are proposed, which allow to assess the degree of system’s integrity. System’s integrity degree ensures sustainability of a system, on the other hand, freedom of system’s elements ensures the system development. The proposed estimates can be used for accessing the influence of digital technologies on the implementation enterprise strategy, ensuring the effectiveness of its development and increasing competitiveness based on the digitalization of production and management while maintaining stable functioning.
    Type of Medium: Online Resource
    ISSN: 1757-8981 , 1757-899X
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2020
    detail.hit.zdb_id: 2506501-4
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  • 8
    In: Biogeosciences, Copernicus GmbH, Vol. 13, No. 12 ( 2016-06-20), p. 3585-3606
    Abstract: Abstract. Recent modeling results suggest that oceanic oxygen levels will decrease significantly over the next decades to centuries in response to climate change and altered ocean circulation. Hence, the future ocean may experience major shifts in nutrient cycling triggered by the expansion and intensification of tropical oxygen minimum zones (OMZs), which are connected to the most productive upwelling systems in the ocean. There are numerous feedbacks among oxygen concentrations, nutrient cycling and biological productivity; however, existing knowledge is insufficient to understand physical, chemical and biological interactions in order to adequately assess past and potential future changes. In the following, we summarize one decade of research performed in the framework of the Collaborative Research Center 754 (SFB754) focusing on climate–biogeochemistry interactions in tropical OMZs. We investigated the influence of low environmental oxygen conditions on biogeochemical cycles, organic matter formation and remineralization, greenhouse gas production and the ecology in OMZ regions of the eastern tropical South Pacific compared to the weaker OMZ of the eastern tropical North Atlantic. Based on our findings, a coupling of primary production and organic matter export via the nitrogen cycle is proposed, which may, however, be impacted by several additional factors, e.g., micronutrients, particles acting as microniches, vertical and horizontal transport of organic material and the role of zooplankton and viruses therein.
    Type of Medium: Online Resource
    ISSN: 1726-4189
    Language: English
    Publisher: Copernicus GmbH
    Publication Date: 2016
    detail.hit.zdb_id: 2158181-2
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  • 9
    Online Resource
    Online Resource
    Copernicus GmbH ; 2019
    In:  Biogeosciences Vol. 16, No. 9 ( 2019-05-15), p. 2033-2047
    In: Biogeosciences, Copernicus GmbH, Vol. 16, No. 9 ( 2019-05-15), p. 2033-2047
    Abstract: Abstract. The eastern tropical South Pacific (ETSP) hosts the Peruvian upwelling system, which represents one of the most productive areas in the world ocean. High primary production followed by rapid heterotrophic utilization of organic matter supports the formation of one of the most intense oxygen minimum zones (OMZs) in the world ocean, where dissolved oxygen (O2) concentrations reach less than 1 µmol kg−1. The high productivity leads to an accumulation of dissolved organic matter (DOM) in the surface layers that may serve as a substrate for heterotrophic respiration. However, the importance of DOM utilization for O2 respiration in the Peruvian upwelling system in general and for shaping the upper oxycline in particular remains unclear so far. This study reports the first estimates of diapycnal fluxes and supply of O2, dissolved organic carbon (DOC), dissolved organic nitrogen, dissolved hydrolysable amino acids (DHAA) and dissolved combined carbohydrates (DCCHO) for the ETSP off Peru. Diapycnal flux and supply estimates were obtained by combining measured vertical diffusivities and solute concentration gradients. They were analysed together with the molecular composition of DCCHO and DHAA to infer the transport of labile DOM into the upper OMZ and the potential role of DOM utilization for the attenuation of the diapycnal O2 flux that ventilates the OMZ. The observed diapycnal O2 flux (50 mmol O2 m−2 d−1 at maximum) was limited to the upper 80 m of the water column; the O2 supply of ∼1 µmol kg−1 d−1 was comparable to previously published O2 consumption rates for the North and South Pacific OMZs. The diapycnal DOM flux (31 mmol C m−2 d−1 at maximum) was limited to ∼30 m water depth, suggesting that the labile DOM is extensively consumed within the upper part of the shallow oxycline off Peru. The analyses of DCCHO and DHAA composition support this finding, suggesting that DOM undergoes comprehensive remineralization within the upper part of the oxycline, as the DOM within the core of the OMZ was found to be largely altered. Estimated by a simple equation for carbon combustion, aerobic respiration of DCCHO and DHAA, supplied by diapycnal mixing (0.46 µmol kg−1 d−1 at maximum), could account for up to 38 % of the diapycnal O2 supply in the upper oxycline, which suggests that DOM utilization plays a significant role for shaping the upper oxycline in the ETSP.
    Type of Medium: Online Resource
    ISSN: 1726-4189
    Language: English
    Publisher: Copernicus GmbH
    Publication Date: 2019
    detail.hit.zdb_id: 2158181-2
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  • 10
    Online Resource
    Online Resource
    MDPI AG ; 2023
    In:  Current Issues in Molecular Biology Vol. 45, No. 6 ( 2023-06-10), p. 5084-5098
    In: Current Issues in Molecular Biology, MDPI AG, Vol. 45, No. 6 ( 2023-06-10), p. 5084-5098
    Abstract: The aim of the study was to determine the content of tumor markers for breast, lung and ovarian cancer in saliva, as well as for benign diseases of the corresponding organs and in the control group, and to evaluate their diagnostic significance. Strictly before the start of treatment, saliva samples were obtained and the concentrations of tumor markers (AFP, NSE, HE4, CA15-3, CA72-4, CA125 and CEA) were determined using an enzyme immunoassay (ELISA). CA125 and HE4 were simultaneously determined to be in the blood serum of patients with ovarian cancer. The concentrations of salivary CEA, NSE, CA15-3, CA72-4 and CA125 of the control group were significantly lower than in oncological diseases; however, these tumor markers also increased in saliva with benign diseases. The content of tumor markers depends on the stage of cancer, and the presence of lymph node metastasis; however, the identified patterns are statistically unreliable. The determination of HE4 and AFP in saliva was not informative. In general, the area of potential use of tumor markers in saliva is extremely narrow. Thus, CEA may be diagnostic for breast and lung cancer, but not for ovarian cancer. CA72-4 is most informative for ovarian mucinous carcinoma. None of the markers showed significant differences between malignant and non-malignant pathologies.
    Type of Medium: Online Resource
    ISSN: 1467-3045
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2090836-2
    SSG: 12
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