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  • 1
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    Online Resource
    Zonation of glucokinase in rat liver changes during postnatal development
    Wiley ; 1993
    In:  FEBS Letters Vol. 328, No. 1-2 ( 1993-08-09), p. 119-124
    Details
    In: FEBS Letters, Wiley, Vol. 328, No. 1-2 ( 1993-08-09), p. 119-124
    Abstract: In the liver many metabolic pathways are preferentially localized in different zones of the acinus. It is assumed that this zonation allows an efficient adaptation to different states of nutrition, because alternative pathways can be regulated independently. It is reported that the rate limiting enzyme for the glycolytic pathway, glucokinase (EC 2.7.1.2), is predominantly located in the pericentral zone. The gene expression of glucokinase is induced to a maximum level after a carbohydrate‐rich diet. In starved or diabetic rats glucokinase gene expression is barely detectable. In postnatal development glucokinase is induced to significant levels only from day 14 onwards. The distribution of the glucokinase protein in the rat liver lobule in the first 4 weeks of postnatal life was investigated by immunohistochemistry and compared to the distribution observed in adult rats. In adult rats considerably high levels of glucokinase are measureable as shown by immunoblotting utilizing a monospecific antibody and a photometric assay of glucokinase enzyme activity, respectively. Immunohistochemically the hepatic glucokinase protein is detected in the perivenous area. During postnatal development, the quantities of hepatic glucokinase protein and glucokinase enzyme activity start to increase significantly from day 15 onwards. Subsequently, glucokinase levels rise further until day 29. In contrast to the results obtained by immunoblotting, glucokinase is already detectable in some liver cells in sections from 6‐day‐old rats by immunohistochemistry. The liver lobule structure at this age is not completely developed, therefore it is not possible to definitely assign these cells to periportal or pericentral areas. At day 10 post partum the number of glucokinase expressing cells, which appear to be localized preferentially in the periportal zone, increases. In agreement with the immunoblotting, an immense increase in glucokinase activity was observed at day 14. The periportal zonation, clearly detectable at this time, remains stable until day 24. In sections from 29‐day‐old rats the periportal zonation begins to change into a more homogeneous pattern with a slight preference for periportal areas. The observed appearance of the periportal zonation of glucokinase during neonatal development is obviously in contrast to the perivenous expression of glucokinase in adult rats.
    Type of Medium: Online Resource
    ISSN: 0014-5793 , 1873-3468
    URL: Article
    DOI: 10.1016/0014-5793(93)80978-4
    RVK:
    WA 15000
    Language: English
    Publisher: Wiley
    Publication Date: 1993
    detail.hit.zdb_id: 1460391-3
    SSG: 12
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  • 2
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    Online Resource
    Short term dynamics of planktonic foraminiferal sedimentation in the Porcupine Seabight
    Micropaleontological Foundation MicroPress Europe ; 2010
    In:  Micropaleontology Vol. 56, No. 3-4 ( 2010), p. 259-274
    Details
    In: Micropaleontology, Micropaleontological Foundation MicroPress Europe, Vol. 56, No. 3-4 ( 2010), p. 259-274
    Abstract: Modern planktonic foraminifera collected with a sediment trap, and subfossil assemblages from surface sediments from the Galway Mound in the Porcupine Seabight off southwestern Ireland, (northeastern Atlantic), were studied in order to investigate recent assemblage variations. The sediment trap operated fromApril to August 2004 with a sampling interval of eight days and covered the spring bloom and early summer. Ten different species were recorded. Globorotalia hirsuta, Turborotalita quinqueloba and Globigerinita glutinata appeared predominately in spring. Eogloboquadrina incompta, Globigerina bulloides and Globorotalia inflata were abundant in spring and summer. Highest foraminiferal tests flux occurred in June. The faunal composition was similar to subfossil assemblages from surface sediments, but the species proportions were different. This contrast wasmainly driven by the subtropical species G. hirsuta, which was frequent in 2004 but rare in surface sediment samples and in earlier plankton collections obtained from the southern Porcupine Seabight during the 1990s. The individual weight of deposited foraminifera is mainly influenced by the spring bloom, as indicated by sea-surface chlorophyll-a data. The top three-ranked species, G. hirsuta, N. incompta and G. bulloides, contributed 87 % to the foraminiferal carbonate flux at Galway Mound.
    Type of Medium: Online Resource
    ISSN: 0026-2803 , 1937-2795
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.47894/mpal.56.3
    DOI: 10.47894/mpal
    DOI: 10.47894/mpal.56.3.02
    RVK:
    TE 1000
    Language: Unknown
    Publisher: Micropaleontological Foundation MicroPress Europe
    Publication Date: 2010
    detail.hit.zdb_id: 415738-2
    detail.hit.zdb_id: 2175613-2
    SSG: 13
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