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  • 1
    Online Resource
    Online Resource
    Molecular mechanisms of trehalose in modulating glucose homeostasis in diabetes
    Elsevier BV ; 2019
    In:  Diabetes & Metabolic Syndrome: Clinical Research & Reviews Vol. 13, No. 3 ( 2019-05), p. 2214-2218
    Details
    In: Diabetes & Metabolic Syndrome: Clinical Research & Reviews, Elsevier BV, Vol. 13, No. 3 ( 2019-05), p. 2214-2218
    Type of Medium: Online Resource
    ISSN: 1871-4021
    URL: Article
    DOI: 10.1016/j.dsx.2019.05.023
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2019
    detail.hit.zdb_id: 2273766-2
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  • 2
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    New insights into cellular links between sodium–glucose cotransporter‐2 inhibitors and ketogenesis
    Wiley ; 2022
    In:  Journal of Cellular Biochemistry Vol. 123, No. 12 ( 2022-12), p. 1879-1890
    Details
    In: Journal of Cellular Biochemistry, Wiley, Vol. 123, No. 12 ( 2022-12), p. 1879-1890
    Abstract: Sodium–glucose cotransporter‐2 inhibitors (SGLT2is) are a newly developed class of highly effective antidiabetic therapies that normalize hyperglycemia via urinary glucose excretion. However, they may be accompanied by certain side effects that negatively impact their therapeutic benefits. SGLT2is induce a metabolic shift from glucose to fatty acids and thus increase lipolysis which, in turn, induces ketogenesis. The complete pathways linking SGLT2is to ketoacidosis have not yet been fully elucidated, though much is now known. Therefore, in this mechanistic study, we present the current knowledge and shed light upon the possible cellular pathways involved. A deeper understanding of the possible links between SGLT2is and ketogenesis could help to prevent adverse side effects in diabetic patients treated with these drugs.
    Type of Medium: Online Resource
    ISSN: 0730-2312 , 1097-4644
    URL: Issue
    URL: Article
    DOI: 10.1002/jcb.v123.12
    DOI: 10.1002/jcb.30327
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1479976-5
    SSG: 12
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  • 3
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    Online Resource
    Astaxanthin and Nrf2 Signaling Pathway: A Novel Target for New Therapeutic Approaches
    Bentham Science Publishers Ltd. ; 2022
    In:  Mini-Reviews in Medicinal Chemistry Vol. 22, No. 2 ( 2022-02), p. 312-321
    Details
    In: Mini-Reviews in Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 22, No. 2 ( 2022-02), p. 312-321
    Abstract: Astaxanthin (AST) is a naturally occurring compound isolated from various sources such as fungi, plants, salmon, and crab. However, Haematococcus Pluvialis, a green alga, is the primary source of this beta carotenoid compound. AST has several favourable biological and pharmacological activities such as antioxidant, anti-inflammatory, anti-tumor, anti-diabetes, hepatoprotective, and neuroprotective activities. Nevertheless, the exact molecular mechanisms of these protective effects of AST are unclear yet. The Nrf2 signaling pathway is one of the critical candidate signaling pathways that may be involved in these beneficial effects of AST. This signaling pathway is responsible for maintaining the redox balance in the physiological state. Upon nuclear translocation, Nrf2 signaling activates antioxidant enzymes to reduce oxidative stress and protect cells against damage. In the current study, we have reviewed the effects of AST on the Nrf2 signaling pathway, which could potentially be developed as a novel therapeutic approach for the management of various diseases.
    Type of Medium: Online Resource
    ISSN: 1389-5575
    URL: Article
    DOI: 10.2174/1389557521666210505112834
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2022
    SSG: 15,3
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  • 4
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    Online Resource
    Obesity and Insulin Resistance: A Review of Molecular Interactions
    Bentham Science Publishers Ltd. ; 2021
    In:  Current Molecular Medicine Vol. 21, No. 3 ( 2021-03), p. 182-193
    Details
    In: Current Molecular Medicine, Bentham Science Publishers Ltd., Vol. 21, No. 3 ( 2021-03), p. 182-193
    Abstract: The prevalence of insulin resistance and diabetes mellitus is rising globally in epidemic proportions. Diabetes and its complications contribute to significant morbidity and mortality. An increase in sedentary lifestyle and consumption of a more energydense diet increased the incidence of obesity which is a significant risk factor for type 2 diabetes. Obesity acts as a potent upstream event that promotes molecular mechanisms involved in insulin resistance and diabetes mellitus. However, the exact molecular mechanisms between obesity and diabetes are not clearly understood. In the current study, we have reviewed the molecular interactions between obesity and type 2 diabetes.
    Type of Medium: Online Resource
    ISSN: 1566-5240
    URL: Article
    DOI: 10.2174/1566524020666200812221527
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2021
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  • 5
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    The Beneficial Effects of Curcumin on Lipids: Possible Effects on Dyslipidemia-Induced Cardiovascular Complications
    Bentham Science Publishers Ltd. ; 2023
    In:  Current Medicinal Chemistry Vol. 31 ( 2023-07-07)
    Details
    In: Current Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 31 ( 2023-07-07)
    Abstract: Dyslipidemia and altered lipid metabolism are closely involved in the pathogenesis and clinical manifestation of many metabolic and non-metabolic diseases. Therefore, mitigation of pharmacological and nutritional factors together with lifestyle modifications is paramount. One potential nutraceutical exhibiting cell signaling and lipid-modulating properties implicated in dyslipidemias is curcumin. Specifically, recent evidence suggest that curcumin may improve lipid metabolism and prevent dyslipidemia-induced cardiovascular complications via several pathways. Although the exact molecular mechanisms involved are not well understood, the evidence presented in this review suggests that curcumin can provide significant lipid benefits via modulation of adipogenesis and lipolysis, and prevention or reduction of lipid peroxidation and lipotoxicity via different molecular pathways. Curcumin can also improve the lipid profile and reduce dyslipidemia-dependent cardiovascular problems by impacting important mechanisms of fatty acid oxidation, lipid absorption, and cholesterol metabolism. Although only limited direct supporting evidence is available, in this review we assess the available knowledge regarding the possible nutraceutical effects of curcumin on lipid homeostasis and its possible impacts on dyslipidemic cardiovascular events from a mechanistic viewpoint.
    Type of Medium: Online Resource
    ISSN: 0929-8673
    URL: Article
    DOI: 10.2174/0929867331666230707094644
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
    SSG: 15,3
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  • 6
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    Online Resource
    Curcumin Therapeutic Modulation of the Wnt Signaling Pathway
    Bentham Science Publishers Ltd. ; 2020
    In:  Current Pharmaceutical Biotechnology Vol. 21, No. 11 ( 2020-09-21), p. 1006-1015
    Details
    In: Current Pharmaceutical Biotechnology, Bentham Science Publishers Ltd., Vol. 21, No. 11 ( 2020-09-21), p. 1006-1015
    Abstract: Curcumin, isolated from the rhizome of Curcuma longa, is one of the most extensively studied phytochemicals. This natural compound has a variety of pharmacological effects including antioxidant, anti-inflammatory, anti-tumor, cardio-protective, hepato-protective and anti-diabetic. Wnt signaling pathway, one of the potential targets of curcumin through upregulation and/or downregulation, plays a significant role in many diseases, even in embryogenesis and development of various organs and systems. In order to exert an anti-tumor activity in the organism, curcumin seems to inhibit the Wnt pathway. The downstream mediators of Wnt signaling pathway such as c-Myc and cyclin D1 are also modified by curcumin. This review demonstrates how curcumin influences the Wnt signaling pathway and is beneficial for the treatment of neurological disorders (Alzheimer’s and Parkinson’s diseases), cancers (melanoma, lung cancer, breast cancer, colon cancer, endothelial carcinoma, gastric carcinoma and hepatocellular carcinoma) and other diseases, such as diabetes mellitus or bone disorders.
    Type of Medium: Online Resource
    ISSN: 1389-2010
    URL: Article
    DOI: 10.2174/1389201021666200305115101
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2020
    SSG: 15,3
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  • 7
    Online Resource
    Online Resource
    Molecular Mechanisms by Which Imeglimin Improves Glucose Homeostasis
    Hindawi Limited ; 2020
    In:  Journal of Diabetes Research Vol. 2020 ( 2020-03-06), p. 1-5
    Details
    In: Journal of Diabetes Research, Hindawi Limited, Vol. 2020 ( 2020-03-06), p. 1-5
    Abstract: Despite different classes of antidiabetic medications available for the management of patients with diabetes, efforts are underway to identify novel and safer antihyperglycemic agents with higher potency and increased tolerability. Imeglimin is a promising antidiabetic agent that has shown to have significant antihyperglycemic effects in studies, although it has not been approved yet. There is growing evidence that imeglimin improves glucose homeostasis in the diabetic milieu; however, the precise molecular mechanisms are still not elucidated. In this review, we discuss various molecular pathways by which imeglimin exerts its antihyperglycemic effects and improves glucose homeostasis in the diabetic milieu.
    Type of Medium: Online Resource
    ISSN: 2314-6745 , 2314-6753
    URL: Article
    DOI: 10.1155/2020/8768954
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2711897-6
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  • 8
    Online Resource
    Online Resource
    Nanoparticles with SGLT2 inhibitory activity: Possible benefits and future
    Elsevier BV ; 2023
    In:  Diabetes & Metabolic Syndrome: Clinical Research & Reviews Vol. 17, No. 10 ( 2023-10), p. 102869-
    Details
    In: Diabetes & Metabolic Syndrome: Clinical Research & Reviews, Elsevier BV, Vol. 17, No. 10 ( 2023-10), p. 102869-
    Type of Medium: Online Resource
    ISSN: 1871-4021
    URL: Article
    DOI: 10.1016/j.dsx.2023.102869
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 2273766-2
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  • 9
    Online Resource
    Online Resource
    Oxidative stress induces renal failure: A review of possible molecular pathways
    Wiley ; 2018
    In:  Journal of Cellular Biochemistry Vol. 119, No. 4 ( 2018-04), p. 2990-2998
    Details
    In: Journal of Cellular Biochemistry, Wiley, Vol. 119, No. 4 ( 2018-04), p. 2990-2998
    Abstract: It has been reported that oxidative stress has a pivotal role in many disorders such as chronic kidney diseases. Free radicals can directly attack cellular elements, trigger intracellular signaling pathways, or induce systemic responses leading to renal damages. In the current review, we evaluated the literature focusing on the main recognized effects of oxidative stress on the pathophysiology of chronic renal disorders. We searched the PubMed‐Medline and Scopus databases by using the following key words: oxidative stress, kidney, chronic kidney diseases, and free radicals and found about 200 related articles. Then, we focused on the molecular mechanisms underlying chronic kidney diseases which can be induced by oxidative stress and explored how free radicals stimulate these mechanisms. By reviewing the literature, we found that there are almost nine important molecular pathways through which free radicals influence the renal function. Based on the retrieved data, oxidative stress has an important role in the pathophysiology of chronic kidney diseases. Understanding these pathophysiologic pathways may lead us to find new approaches for the management of these debilitating disorders.
    Type of Medium: Online Resource
    ISSN: 0730-2312 , 1097-4644
    URL: Issue
    URL: Article
    DOI: 10.1002/jcb.v119.4
    DOI: 10.1002/jcb.26450
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 1479976-5
    SSG: 12
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  • 10
    Online Resource
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    Antidiabetic potential of saffron and its active constituents
    Wiley ; 2019
    In:  Journal of Cellular Physiology Vol. 234, No. 6 ( 2019-06), p. 8610-8617
    Details
    In: Journal of Cellular Physiology, Wiley, Vol. 234, No. 6 ( 2019-06), p. 8610-8617
    Abstract: The prevalence of diabetes mellitus is growing rapidly worldwide. This metabolic disorder affects many physiological pathways and is a key underlying cause of a multitude of debilitating complications. There is, therefore, a critical need for effective diabetes management. Although many synthetic therapeutic glucose‐lowering agents have been developed to control glucose homeostasis, they may have unfavorable side effects or limited efficacy. Herbal‐based hypoglycemic agents present an adjunct treatment option to mitigate insulin resistance, improve glycemic control and reduce the required dose of standard antidiabetic medications. Saffron ( Crocus sativus L.), whilst widely used as a food additive, is a natural product with insulin‐sensitizing and hypoglycemic effects. Saffron contains several bioactive β carotenes, which exert their pharmacological effects in various tissues without any obvious side effects. In this study, we discuss how saffron and its major components exert their hypoglycemic effects by induction of insulin sensitivity, improving insulin signaling and preventing β‐cell failure, all mechanisms combining to achieve better glycemic control.
    Type of Medium: Online Resource
    ISSN: 0021-9541 , 1097-4652
    URL: Issue
    URL: Article
    DOI: 10.1002/jcp.v234.6
    DOI: 10.1002/jcp.27843
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 1478143-8
    SSG: 12
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