In:
Materials Testing, Walter de Gruyter GmbH, Vol. 56, No. 4 ( 2014-04-01), p. 331-335
Abstract:
A novel copolymer was synthesized by modifying starch-g-polylactic acid (MSt-g-PLA). The results indicated that the starch was efficiently esterified by maleic anhydride (MAH) (2 wt.-%) with polyethylene glycol-400 (PEG-400, 1 wt.-%) as dispersant. Then MSt-g-PLA was synthesized by the reaction of modified starch with D,L-lactic acid. The copolymer was amphiphilic and its molecular weight was 4.789 × 10 4 (M n ), molecular weight distribution was 6.921 × 10 4 (M w ), and polydispersity index was 1.445 (PDI), respectively. Subsequently, CTX/MSt-g-PLA microspheres containing the model drug and cefotaxime sodium (CTX) were prepared. The appearance of the microspheres was smooth and regular. 90 % of particle size was under 150.3 μm and mean diameter was 99.3 μm. The degradation rates of microspheres increased with the increase of pH-value of the buffer. With the amphiphilic copolymer MSt-g-PLA as drug carrier, the microspheres had no burst during drug release, and had the similar sustainable release as the PLA carriers.
Type of Medium:
Online Resource
ISSN:
2195-8572
,
0025-5300
Language:
English
Publisher:
Walter de Gruyter GmbH
Publication Date:
2014
detail.hit.zdb_id:
2280363-4
detail.hit.zdb_id:
206395-5
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