In:
Surface and Interface Analysis, Wiley, Vol. 45, No. 1 ( 2013-01), p. 248-250
Abstract:
Imaging with time‐of‐flight secondary ion mass spectrometry (TOF‐SIMS) has been shown to be a powerful analytical tool for mapping the distribution of biologically relevant small molecules ( 〈 1000 Da) on a surface. To improve the success rate of sample preparation, a device was designed to cells freeze‐fracture by using powerful magnets. Quantum dots (QDs) were used to observe the changes in the cell after freeze‐fracture. Then, TOF‐SIMS was employed to analyze the ionic and molecular distribution in the cells associated with the disease. Copyright © 2012 John Wiley & Sons, Ltd.
Type of Medium:
Online Resource
ISSN:
0142-2421
,
1096-9918
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
2023881-2
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