In:
International Journal of Sports Medicine, Georg Thieme Verlag KG, Vol. 41, No. 09 ( 2020-08), p. 582-588
Abstract:
Acute prolonged endurance running has been shown to alter muscle-specific
circulating microRNA (miRNA) levels. Here, eighteen participants completed an 8 km run. We assessed the levels of hsa-miR-1–3p, -133a-3p, -133b, and
-206 and their correlation with conventional biomarkers following exercise. Compared to before exercise (Pre), 8 km run significantly increased the
lactate level immediately after exercise (0 h). Myoglobin (Mb) level increased at 0 h while creatine kinase (CK) level increased 24 h after exercise (24 h).
The levels of creatine kinase MB isoenzyme (CK-MB) and cardiac troponin I (cTnI) were all elevated at 24 h and within the normal physiological range; The levels
of hsa-miR-1–3p, -133a-3p, -133b significantly increased at 0 h but only hsa-miR-133a-3p still elevated at 24 h. Only hsa-miR-206 level decreased at 24
h; Additionally, the changes of hsa-miR-1–3p and hsa-miR-133a-3p were correlated with Mb at 24 h. These findings suggest that muscle-specific miRNA
elevation in plasma is likely physiological and that these miRNA may be used as potential biomarkers for load monitoring in individuals.
Type of Medium:
Online Resource
ISSN:
0172-4622
,
1439-3964
Language:
English
Publisher:
Georg Thieme Verlag KG
Publication Date:
2020
detail.hit.zdb_id:
2041541-2
SSG:
31
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