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  • 1
    In: International Journal of Sports Medicine, Georg Thieme Verlag KG, Vol. 43, No. 10 ( 2022-09), p. 889-894
    Abstract: Head Injury Assessment (HIA) is the screening tool for head injury during a rugby game. The purpose of this study was to investigate the epidemiology of HIA in the Japan Rugby Top League (JRTL). The incidences of HIA, defined concussion (per 1,000 player-hours) and repeated concussions were evaluated in three seasons (2016-17, 2017–18, 2018–19; total 360 games). The HIA incidence rates were 12.7 (95% confidence interval 9.5–15.9), 20.8 (16.8–24.9), and 25.0 (20.5–29.5) in each season. HIA-1 criteria 2, which is applied for suspected concussion cases, was performed for 46 cases in the 2016–17 season, 81 cases in the 2017–18 season, and 88 cases in the 2018–19 season. The concussion incidence rates were significantly greater in the 2017–18 season (9.6/1000 player-hours, 95% confidence interval 6.8–12.4) and the 2018–19 season (14.4, 11–17.8) compared to the 2016–17 season (4.8, 2.8–6.8). The number of repeated concussion cases in the same season was 1 in the 2016–17 season and 4 in both the 2017–18 and 2018–19 seasons. This study confirmed significantly higher HIA and concussion incidence rates over time. Although the HIA system might have been established in the three seasons in JRTL, comprehensive management needs to be improved to prevent repeated concussions.
    Type of Medium: Online Resource
    ISSN: 0172-4622 , 1439-3964
    RVK:
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2022
    detail.hit.zdb_id: 2041541-2
    detail.hit.zdb_id: 603122-5
    SSG: 31
    Location Call Number Limitation Availability
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  • 2
    In: Medicine & Science in Sports & Exercise, Ovid Technologies (Wolters Kluwer Health), Vol. 50, No. 12 ( 2018-12), p. 2433-2441
    Abstract: Although several genetic factors may play a role in leisure-time exercise behavior, there is currently no evidence of a significant genomewide association, and candidate gene replication studies have produced inconsistent results. Methods We conducted a two-stage genomewide association study and candidate single-nucleotide polymorphisms (SNP) association study on leisure-time exercise behavior using 13,980 discovery samples from the Japan Multi-Institutional Collaborative Cohort (J-MICC) study, and 2036 replication samples from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center-2 study. Leisure-time physical activity was measured using a self-administered questionnaire that inquired about the type, frequency and duration of exercise. Participants with ≥4 MET·h·wk −1 of leisure-time physical activity were defined as exhibiting leisure-time exercise behavior. Association testing using mixed linear regression models was performed on the discovery and replication samples, after which the results were combined in a meta-analysis. In addition, we tested six candidate genetic variants derived from previous genomewide association study. Results We found that one novel SNP (rs10252228) located in the intergenic region between NPSR1 and DPY19L1 was significantly associated with leisure-time exercise behavior in discovery samples. This association was also significant in replication samples (combined P value by meta-analysis = 2.2 × 10 −9 ). Several SNP linked with rs10252228 were significantly associated with gene expression of DPY19L1 and DP19L2P1 in skeletal muscle, heart, whole blood, and the nervous system. Among the candidate SNP, rs12612420 in DNAPTP6 demonstrated nominal significance in discovery samples but not in replication samples. Conclusions We identified a novel genetic variant associated with regular leisure-time exercise behavior. Further functional studies are required to validate the role of these variants in exercise behavior.
    Type of Medium: Online Resource
    ISSN: 1530-0315 , 0195-9131
    RVK:
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2018
    detail.hit.zdb_id: 603994-7
    detail.hit.zdb_id: 2031167-9
    SSG: 31
    Location Call Number Limitation Availability
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