In:
Medicine & Science in Sports & Exercise, Ovid Technologies (Wolters Kluwer Health), Vol. 52, No. 4 ( 2020-4), p. 810-819
Abstract:
This study aimed to investigate baseline, exercise testing, and exercise training–mediated predictors of change in peak oxygen uptake (V˙O 2peak ) from baseline to 12-wk follow-up (ΔV˙O 2peak ) in a post hoc analysis from the SMARTEX Heart Failure trial. Methods We studied 215 patients with heart failure with left ventricular ejection fraction (LVEF) ≤35%, and New York Heart Association (NYHA) classes II–III who were randomized to either supervised high-intensity interval training with exercise target intensity of 90%–95% of peak heart rate (HR peak ) or supervised moderate continuous training (MCT) with target intensity of 60%–70% of HR peak , or who received a recommendation of regular exercise on their own. Predictors of ΔV˙O 2peak were assessed in two models: a logistic regression model comparing highest and lowest tertiles (baseline parameters) and a multivariate linear regression model (test/training/clinical parameters). Results The change in V˙O 2peak in response to the interventions (ΔV˙O 2peak ) varied substantially, from −8.50 to +11.30 mL·kg −1 ·min −1 . Baseline NYHA (class II gave higher odds vs III; odds ratio (OR), 7.1 (2.0–24.9); P = 0.002), LVEF (OR per percent, 1.1 (1.0–1.2); P = 0.005), and age (OR per 10 yr, 0.5 (0.3–0.8); P = 0.003) were associated with ΔV˙O 2peak . In the multivariate linear regression, 34% of the variability in ΔV˙O 2peak was explained by the increase in exercise training workload, ΔHR peak between baseline and 12-wk posttesting, age, and ever having smoked. Conclusion Exercise training response (ΔV˙O 2peak ) correlated negatively with age, LVEF, and NYHA class. The ability to increase workload during the training period and increased ΔHR peak between baseline and the 12-wk test were associated with a positive outcome.
Type of Medium:
Online Resource
ISSN:
1530-0315
,
0195-9131
DOI:
10.1249/MSS.0000000000002193
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2020
detail.hit.zdb_id:
2031167-9
SSG:
31
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