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  • 1
    In: Nature, Springer Science and Business Media LLC, Vol. 603, No. 7903 ( 2022-03-31), p. 919-925
    Abstract: Omicron (B.1.1.529), the most heavily mutated SARS-CoV-2 variant so far, is highly resistant to neutralizing antibodies, raising concerns about the effectiveness of antibody therapies and vaccines 1,2 . Here we examined whether sera from individuals who received two or three doses of inactivated SARS-CoV-2 vaccine could neutralize authentic Omicron. The seroconversion rates of neutralizing antibodies were 3.3% (2 out of 60) and 95% (57 out of 60) for individuals who had received 2 and 3 doses of vaccine, respectively. For recipients of three vaccine doses, the geometric mean neutralization antibody titre for Omicron was 16.5-fold lower than for the ancestral virus (254). We isolated 323 human monoclonal antibodies derived from memory B cells in triple vaccinees, half of which recognized the receptor-binding domain, and showed that a subset (24 out of 163) potently neutralized all SARS-CoV-2 variants of concern, including Omicron. Therapeutic treatments with representative broadly neutralizing monoclonal antibodies were highly protective against infection of mice with SARS-CoV-2 Beta (B.1.351) and Omicron. Atomic structures of the Omicron spike protein in complex with three classes of antibodies that were active against all five variants of concern defined the binding and neutralizing determinants and revealed a key antibody escape site, G446S, that confers greater resistance to a class of antibodies that bind on the right shoulder of the receptor-binding domain by altering local conformation at the binding interface. Our results rationalize the use of three-dose immunization regimens and suggest that the fundamental epitopes revealed by these broadly ultrapotent antibodies are rational targets for a universal sarbecovirus vaccine.
    Type of Medium: Online Resource
    ISSN: 0028-0836 , 1476-4687
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    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 120714-3
    detail.hit.zdb_id: 1413423-8
    SSG: 11
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  • 2
    In: Advanced Materials, Wiley
    Abstract: Integrating the merits of low cost, flexibility, and large‐area processing, organic semiconductors (OSCs) are promising candidates for next‐generation electronic materials. The mobility and stability are the key figure of merit for its practical application. However, it is greatly challenging to improve the mobility and stability simultaneously owing to the weak interactions and poor electronic coupling between OSCs molecules. Here, we developed an oxygen‐induced lattice strain (OILS) strategy to achieve OSCs with both high‐mobility and high‐stability. Utilizing the strategy, the maximum mobility of dinaphtho[2,3‐b:2′,3′‐f]thieno[3,2‐b] thiophene (DNTT) organic field‐effect transistor (OFET) rises to 15.3 cm 2 V −1 s −1 and the contact resistance lowers to 25.5 Ω·cm. Remarkably, the thermal stability of DNTT is much improved, and a record saturated power density of approximately 3.4×10 4  W cm −2 is obtained. Both the experiments and theoretical calculations demonstrate that the lattice compressive strain induced by oxygen is responsible for the high performance and stability. Furthermore, the universality of the strategy is manifested in both n‐type and p‐type small OSCs. This work provides a novel strategy to improve both the mobility and the stability of OSCs, paving the way for the practical applications of organic devices. This article is protected by copyright. All rights reserved
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
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    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1474949-X
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  • 3
    In: Advanced Materials, Wiley, Vol. 34, No. 51 ( 2022-12)
    Abstract: Living cells comprise diverse subcellular structures, such as cytoskeletal networks, which can regulate essential cellular activities through dynamic assembly and synergistic interactions with biomolecular condensates. Despite extensive efforts, reproducing viscoelastic networks for modulating biomolecular condensates in synthetic systems remains challenging. Here, a new aqueous two‐phase system (ATPS) is proposed, which consists of poly( N ‐isopropylacrylamide) (PNIPAM) and dextran (DEX), to construct viscoelastic networks capable of being assembled and dissociated dynamically to regulate the self‐assembly of condensates on‐demand. Viscoelastic networks are generated using liquid–liquid phase‐separated DEX droplets as templates and the following liquid‐to‐solid transition of the PNIPAM‐rich phase. The resulting networks can dissolve liquid fused in sarcoma (FUS) condensates within 5 min. This work demonstrates rich phase‐separation behaviors in a single ATPS through incorporating stimuli‐responsive polymers. The concept can potentially be applied to other macromolecules through other stimuli to develop materials with rich phase behaviors and hierarchical structures.
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Issue
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    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1474949-X
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  • 4
    In: Advanced Materials, Wiley, Vol. 34, No. 51 ( 2022-12)
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Issue
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    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1474949-X
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  • 5
    In: The Astrophysical Journal, American Astronomical Society, Vol. 896, No. 1 ( 2020-06-01), p. 4-
    Abstract: Gamma-ray burst (GRB) 150910A was detected by Swift/Burst Alert Telescope (BAT), and then rapidly observed by Swift/XRT, Swift/Ultraviolet-Optical Telescope, and ground-based telescopes. We report Lick Observatory spectroscopic and photometric observations of GRB 150910A, and we investigate the physical origins of both the optical and X-ray afterglows, incorporating data obtained with BAT and XRT. The light curves show that the jet-emission episode lasts ∼360 s with a sharp pulse from BAT to XRT (Episode I). In Episode II, the optical emission has a smooth onset bump followed by a normal decay ( α R,2  ≈ −1.36), as predicted in the standard external shock model, while the X-ray emission exhibits a plateau ( α X,1  ≈ −0.36) followed by a steep decay ( α X,2  ≈ −2.12). The light curves show obvious chromatic behavior with an excess in the X-ray flux. Our results suggest that GRB 150910A is an unusual GRB driven by a newly born magnetar with its extremely energetic magnetic dipole (MD) wind in Episode II, which overwhelmingly dominates the observed early X-ray plateau. The radiative efficiency of the jet prompt emission is η γ  ≈ 11%. The MD wind emission was detected in both the BAT and XRT bands, making it the brightest among the current sample of MD winds seen by XRT. We infer the initial spin period ( P 0 ) and the surface polar cap magnetic field strength ( B p ) of the magnetar as 1.02 × 10 15 G ≤  B p  ≤ 1.80 × 10 15 G and 1 ms ≤  P 0 v  ≤ 1.77 ms, and the radiative efficiency of the wind is η w  ≥ 32%.
    Type of Medium: Online Resource
    ISSN: 0004-637X , 1538-4357
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    Language: Unknown
    Publisher: American Astronomical Society
    Publication Date: 2020
    detail.hit.zdb_id: 2207648-7
    detail.hit.zdb_id: 1473835-1
    SSG: 16,12
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  • 6
    In: Advanced Materials, Wiley, Vol. 30, No. 25 ( 2018-06)
    Abstract: The layered ternary compound TaIrTe 4 is an important candidate to host the recently predicted type‐II Weyl fermions. However, a direct and definitive proof of the absence of inversion symmetry in this material, a prerequisite for the existence of Weyl Fermions, has so far remained evasive. Herein, an unambiguous identification of the broken inversion symmetry in TaIrTe 4 is established using angle‐resolved polarized Raman spectroscopy. Combining with high‐resolution transmission electron microscopy, an efficient and nondestructive recipe to determine the exact crystallographic orientation of TaIrTe 4 crystals is demonstrated. Such technique could be extended to the fast identification and characterization of other type‐II Weyl fermions candidates. A surprisingly strong in‐plane electrical anisotropy in TaIrTe 4 thin flakes is also revealed, up to 200% at 10 K, which is the strongest known electrical anisotropy for materials with comparable carrier density, notably in such good metals as copper and silver.
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Issue
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    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 1474949-X
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  • 7
    Online Resource
    Online Resource
    American Astronomical Society ; 2022
    In:  The Astronomical Journal Vol. 164, No. 5 ( 2022-11-01), p. 203-
    In: The Astronomical Journal, American Astronomical Society, Vol. 164, No. 5 ( 2022-11-01), p. 203-
    Abstract: We are using archived data from HST of transiting exoplanet L 98-59 b to place constraints on its potentially hot atmosphere. We analyze the data from five transit visits and extract the final combined transmission spectrum using Iraclis. Then we use the inverse atmospheric retrieval code TauREx to analyze the combined transmission spectrum. There is a weak absorption feature near 1.40 μ m and 1.55 μ m in the transmission spectrum, which can be modeled by a cloudy atmosphere with abundant hydrogen cyanide (HCN). However, the unrealistically high abundance of HCN derived cannot be explained by any equilibrium chemical model with reasonable assumptions. Thus, the likeliest scenario is that L 98-59 b has a flat, featureless transmission spectrum in the WFC3/G141 bandpass due to a thin atmosphere with high mean molecular weight, an atmosphere with an opaque aerosol layer, or no atmosphere, and it is very unlikely for L 98-59 b to have a clear hydrogen-dominated primary atmosphere. Due to the narrow wavelength coverage and low spectral resolution of HST/WFC3 G141 grism observation, we cannot tell these different scenarios apart. Our simulation shows future higher precision measurements over wider wavelengths from the James Webb Space Telescope can be used to better characterize the planetary atmosphere of L 98-59 b.
    Type of Medium: Online Resource
    ISSN: 0004-6256 , 1538-3881
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    Language: Unknown
    Publisher: American Astronomical Society
    Publication Date: 2022
    detail.hit.zdb_id: 2207625-6
    detail.hit.zdb_id: 2003104-X
    SSG: 16,12
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