In:
Advanced Materials, Wiley, Vol. 35, No. 35 ( 2023-09)
Abstract:
The combination of ferroptosis inducers and immune checkpoint blockade can enhance antitumor effects. However, the efficacy in tumors with low immunogenicity requires further investigation. In this work, a water‐in‐oil Pickering emulsion gel is developed to deliver (1S, 3R)‐RSL‐3 (RSL‐3), a ferroptosis inducer dissolved in iodized oil, and programmed death‐1 (PD‐1) antibody, the most commonly used immune checkpoint inhibitor dissolved in water, with optimal characteristics (RSL‐3 + PD‐1@gel). Tumor lipase degrades the continuous oil phase, which results in the slow release of RSL‐3 and PD‐1 antibody and a notable antitumor effect against low‐immunogenic hepatocellular carcinoma and pancreatic cancer. Intriguingly, the RSL‐3 + PD‐1@gel induces ferroptosis of tumor cells, resulting in antitumor immune response via accumulation of helper T lymphocyte cells and cytotoxic T cells. Additionally, the single‐cell sequence profiling analysis during tumor treatment reveals the induction of ferroptosis in tumor cells together with strong antitumor immune response in ascites.
Type of Medium:
Online Resource
ISSN:
0935-9648
,
1521-4095
DOI:
10.1002/adma.202303542
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
1474949-X
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