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  • 1
    Online Resource
    Online Resource
    Near-infrared imaging polarimetry toward M 17 SWex
    Oxford University Press (OUP) ; 2019
    In:  Publications of the Astronomical Society of Japan Vol. 71, No. Supplement_1 ( 2019-12-01)
    Details
    In: Publications of the Astronomical Society of Japan, Oxford University Press (OUP), Vol. 71, No. Supplement_1 ( 2019-12-01)
    Abstract: We conducted near-infrared ($\mathit {JHK}_{\rm s}$) imaging polarimetry toward the infrared dark cloud (IRDC) M 17 SWex, including almost all of the IRDC filaments as well as its outskirts, with the polarimeter SIRPOL on the IRSF 1.4 m telescope. We revealed the magnetic fields of M 17 SWex with our polarization-detected sources that were selected by some criteria based on their near-IR colors and the column densities toward them, which were derived from the Herschel data. The selected sources indicate not only that the ordered magnetic field is perpendicular to the cloud elongation as a whole, but also that at both ends of the elongated cloud the magnetic field appears to be bent toward its central part, i.e., a large-scale hourglass-shaped magnetic field perpendicular to the cloud elongation. In addition to this general trend, the elongations of the filamentary subregions within the dense parts of the cloud appear to be mostly perpendicular to their local magnetic fields, while the magnetic fields of the outskirts appear to follow the thin filaments that protrude from the dense parts. The magnetic strengths were estimated to be ∼70–$300\, \mu$G in the subregions, of which the lengths and average number densities are ∼3–9 pc and ∼2–7 × 103 cm−3, respectively, by the Davis–Chandrasekhar–Fermi method with the angular dispersion of our polarization data and the velocity dispersion derived from the C18O (J = 1–0) data obtained by the Nobeyama 45 m telescope. These field configurations and our magnetic stability analysis of the subregions imply that the magnetic field has controlled the formation/evolution of the M 17 SWex cloud.
    Type of Medium: Online Resource
    ISSN: 0004-6264 , 2053-051X
    URL: Article
    DOI: 10.1093/pasj/psz072
    RVK:
    US 1090
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
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    SSG: 16,12
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  • 2
    Online Resource
    Online Resource
    DOCK2 is involved in the host genetics and biology of severe COVID-19
    Springer Science and Business Media LLC ; 2022
    In:  Nature Vol. 609, No. 7928 ( 2022-09-22), p. 754-760
    Details
    In: Nature, Springer Science and Business Media LLC, Vol. 609, No. 7928 ( 2022-09-22), p. 754-760
    Abstract: Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge 1–5 . Here we conducted a genome-wide association study (GWAS) involving 2,393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3,289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene ( DOCK2 ), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis ( n  = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target.
    Type of Medium: Online Resource
    ISSN: 0028-0836 , 1476-4687
    URL: Article
    DOI: 10.1038/s41586-022-05163-5
    RVK:
    TA 1000
    RVK:
    UA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
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    detail.hit.zdb_id: 1413423-8
    SSG: 11
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