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  • 1
    Online Resource
    Online Resource
    Union of Swiss Societies for Experimental Biology Abstracts of the 2nd Annual Meeting : Fribourg, 23.–24. Mai 1970
    Springer Science and Business Media LLC ; 1970
    In:  Experientia Vol. 26, No. 6 ( 1970-6), p. 677-696
    Details
    In: Experientia, Springer Science and Business Media LLC, Vol. 26, No. 6 ( 1970-6), p. 677-696
    Type of Medium: Online Resource
    ISSN: 0014-4754 , 1420-9071
    URL: Article
    DOI: 10.1007/BF01898761
    RVK:
    TA 1000
    Language: German
    Publisher: Springer Science and Business Media LLC
    Publication Date: 1970
    detail.hit.zdb_id: 1458497-9
    Location Call Number Limitation Availability
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  • 2
    Online Resource
    Online Resource
    The concept of symmorphosis: a testable hypothesis of structure-function relationship.
    Proceedings of the National Academy of Sciences ; 1991
    In:  Proceedings of the National Academy of Sciences Vol. 88, No. 22 ( 1991-11-15), p. 10357-10361
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 88, No. 22 ( 1991-11-15), p. 10357-10361
    Abstract: The hypothesis that, in biological organisms, structural design is matched to functional demand is difficult to test because it is largely based on anecdotal evidence suggesting economic design. The hypothesis of symmorphosis postulates a quantitative match of design and function parameters within a defined functional system; because of its stringency it is refutable and can, therefore, be subjected to empirical test, for example, by assessing whether the structures that support the pathway for oxygen from the lung to the consumer in muscle cells are quantitatively adjusted to the limit of functional performance of the respiratory system. The study of allometric and adaptive variation leads to the conclusion that the hypothesis of symmorphosis is acceptable for all internal compartments of the respiratory system (blood, heart, muscle capillaries, and mitochondria), whereas it must be refuted for the lung that forms the interface to the environment.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.88.22.10357
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 1991
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
    SSG: 11
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    Oxidative capacity of muscle and mitochondria: correlation of physiological, biochemical, and morphometric characteristics.
    Proceedings of the National Academy of Sciences ; 1989
    In:  Proceedings of the National Academy of Sciences Vol. 86, No. 5 ( 1989-03), p. 1583-1587
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 86, No. 5 ( 1989-03), p. 1583-1587
    Abstract: The oxidative capacity of cat skeletal muscles (soleus, gracilis, and gracilis chronically stimulated for 28 days) was derived from the total mitochondrial content in the muscle, the surface area of mitochondrial inner membranes, and respiratory activities of isolated mitochondria. Mitochondrial content was estimated by standard morphometry. The surface area of mitochondrial inner membranes per unit volume of mitochondria was estimated by a stereological method. The respiratory activities of isolated mitochondria were measured biochemically, using pyruvate/malate, glutamate/malate, succinate, or cytochrome c as substrate. Structurally and functionally, mitochondria from the three muscle types showed nearly identical characteristics. Oxidative activity was dependent on substrate; with succinate, 5.8 ml of O2 per min per ml of mitochondria was the rate most likely to represent physiological conditions. Oxidative activities of 3.1 ml.min-1.ml-1 with pyruvate/malate and 14.5 ml.min-1.ml-1 with cytochrome c as substrates were theoretical lower and upper bounds. The oxidative capacity of each of the three muscles was thus in direct proportion to the total volume of mitochondria in the muscle. The respiratory capacity of isolated mitochondria was very near to the maximal oxygen uptake rate of mitochondria that is commonly estimated in intact muscles of a wide variety of animals.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.86.5.1583
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 1989
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
    SSG: 11
    SSG: 12
    Location Call Number Limitation Availability
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  • 4
    Online Resource
    Online Resource
    An optimal bronchial tree may be dangerous
    Springer Science and Business Media LLC ; 2004
    In:  Nature Vol. 427, No. 6975 ( 2004-2), p. 633-636
    Details
    In: Nature, Springer Science and Business Media LLC, Vol. 427, No. 6975 ( 2004-2), p. 633-636
    Type of Medium: Online Resource
    ISSN: 0028-0836 , 1476-4687
    URL: Article
    DOI: 10.1038/nature02287
    RVK:
    TA 1000
    RVK:
    UA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2004
    detail.hit.zdb_id: 120714-3
    detail.hit.zdb_id: 1413423-8
    SSG: 11
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  • 5
    Online Resource
    Online Resource
    Smaller is better—but not too small: A physical scale for the design of the mammalian pulmonary acinus
    Proceedings of the National Academy of Sciences ; 2002
    In:  Proceedings of the National Academy of Sciences Vol. 99, No. 16 ( 2002-08-06), p. 10411-10416
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 99, No. 16 ( 2002-08-06), p. 10411-10416
    Abstract: The transfer of oxygen from air to blood in the lung involves three processes: ventilation through the airways, diffusion of oxygen in the air phase to the alveolar surface, and finally diffusion through tissue into the capillary blood. The latter two steps occur in the acinus, where the alveolar gas-exchange surface is arranged along the last few generations of airway branching. For the acinus to work efficiently, oxygen must reach the last branches of acinar airways, even though some of it is absorbed along the way. This “screening effect” is governed by the relative values of physical factors like diffusivity and permeability as well as size and design of the acinus. Physics predicts that efficient acini should be space-filling surfaces and should not be too large. It is shown that the mammalian acini fulfill these requirements, small mammals being more efficient than large ones both at rest and in exercise.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.122352499
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2002
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
    SSG: 11
    SSG: 12
    Location Call Number Limitation Availability
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    Online Resource
  • 6
    Online Resource
    Online Resource
    Microoxen: Microorganisms to move microscale loads
    Proceedings of the National Academy of Sciences ; 2005
    In:  Proceedings of the National Academy of Sciences Vol. 102, No. 34 ( 2005-08-23), p. 11963-11967
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 102, No. 34 ( 2005-08-23), p. 11963-11967
    Abstract: It is difficult to harness the power generated by biological motors to carry out mechanical work in systems outside the cell. Efforts to capture the mechanical energy of nanomotors ex vivo require in vitro reconstitution of motor proteins and, often, protein engineering. This study presents a method for harnessing the power produced by biological motors that uses intact cells. The unicellular, biflagellated algae Chlamydomonas reinhardtii serve as “microoxen.” This method uses surface chemistry to attach loads (1- to 6-μm-diameter polystyrene beads) to cells, phototaxis to steer swimming cells, and photochemistry to release loads. These motile microorganisms can transport microscale loads (3-μm-diameter beads) at velocities of ≈100–200 μm·sec –1 and over distances as large as 20 cm.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.0505481102
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2005
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
    SSG: 11
    SSG: 12
    Location Call Number Limitation Availability
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