In:
Science, American Association for the Advancement of Science (AAAS), Vol. 316, No. 5831 ( 2007-06-15), p. 1615-1618
Abstract:
α -klotho was identified as a gene associated with premature aging–like phenotypes characterized by short lifespan. In mice, we found the molecular association of α-Klotho (α-Kl) and Na + ,K + -adenosine triphosphatase (Na + ,K + -ATPase) and provide evidence for an increase of abundance of Na + ,K + -ATPase at the plasma membrane. Low concentrations of extracellular free calcium ([Ca 2+ ] e ) rapidly induce regulated parathyroid hormone (PTH) secretion in an α-Kl- and Na + ,K + -ATPase–dependent manner. The increased Na + gradient created by Na + ,K + -ATPase activity might drive the transepithelial transport of Ca 2+ in cooperation with ion channels and transporters in the choroid plexus and the kidney. Our findings reveal fundamental roles of α-Kl in the regulation of calcium metabolism.
Type of Medium:
Online Resource
ISSN:
0036-8075
,
1095-9203
DOI:
10.1126/science.1135901
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2007
detail.hit.zdb_id:
128410-1
detail.hit.zdb_id:
2066996-3
detail.hit.zdb_id:
2060783-0
SSG:
11
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