In:
Annals of the New York Academy of Sciences, Wiley, Vol. 1067, No. 1 ( 2006-05), p. 301-308
Abstract:
Abstract: We have studied the association of three single nucleotide polymorphisms (SNPs) present in the three HSP70 (heat‐shock protein) genes on 6p21 with human longevity. The availability of biological samples from various population cohorts in Denmark has given us the opportunity to try novel methods of gene association with human longevity. A significant association of one haplotype with male longevity was observed. Furthermore, a significant difference in the survival of the carriers of the different genotypes in females was observed. We also found an age‐dependant decline in the ability of peripheral blood mononuclear cells to respond to heat stress in terms of Hsp70 induction.
Type of Medium:
Online Resource
ISSN:
0077-8923
,
1749-6632
DOI:
10.1196/annals.1354.040
Language:
English
Publisher:
Wiley
Publication Date:
2006
detail.hit.zdb_id:
2834079-6
detail.hit.zdb_id:
211003-9
detail.hit.zdb_id:
2071584-5
SSG:
11
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