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  • 1
    Online Resource
    Online Resource
    Morphactins, a Novel Group of Plant-growth Regulators
    Springer Science and Business Media LLC ; 1965
    In:  Nature Vol. 208, No. 5014 ( 1965-12), p. 1013-1013
    Details
    In: Nature, Springer Science and Business Media LLC, Vol. 208, No. 5014 ( 1965-12), p. 1013-1013
    Type of Medium: Online Resource
    ISSN: 0028-0836 , 1476-4687
    URL: Article
    DOI: 10.1038/2081013a0
    RVK:
    TA 1000
    RVK:
    UA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 1965
    detail.hit.zdb_id: 120714-3
    detail.hit.zdb_id: 1413423-8
    SSG: 11
    Location Call Number Limitation Availability
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  • 2
    Online Resource
    Online Resource
    Biology and Plasticity of CD133 + Hematopoietic Stem Cells
    Wiley ; 2003
    In:  Annals of the New York Academy of Sciences Vol. 996, No. 1 ( 2003-05), p. 141-151
    Details
    In: Annals of the New York Academy of Sciences, Wiley, Vol. 996, No. 1 ( 2003-05), p. 141-151
    Abstract: A bstract : AC133 (CD133) is a highly conserved antigen expressed on hematopoietic stem cells with unknown function. In order to further characterize CD133 + progenitor cells, we purified CD133 + stem cells using the method of magnetic activated cell sorting (MACS) from healthy adult volunteers mobilized with granulocyte colony‐stimulating growth factor (G‐CSF) to a mean purity of 94%. The purified CD133 + cells highly engrafted NOD/SCID mice. In addition, unseparated mononuclear cells or CD133 + stem cells isolated from the bone marrow of transplanted NOD/SCID mice gave rise to engraftment of secondary recipients. Upon ex vivo culture of purified CD133 + cells with FLT3/Flk2 ligand (FL) and interleukin‐6 (IL‐6), a plastic‐adherent cell population could be observed after 6 weeks in culture. These adherent cells did not express CD34 or CD133 antigens on their surface, nor did they express markers for endothelial, mesenchymal, or dendritic cells. After incubation of these adherent cells with stem cell factor (SCF), non‐adherent cells were observed which partially co‐expressed CD133, but were negative for CD34. These nonadherent CD34 − cells showed a high engraftment capacity in NOD/SCID mice. From our results, we conclude that CD133 might be a marker of early progenitors with a high NOD/SCID engraftment potential. The fact that CD133 + hematopoietic progenitors can give rise to an adherent population which is CD133 − and CD34 − and that these cells can again give rise to a CD133 + CD34 − stem cell population with high NOD/SCID engraftment potential indicates the plasticity of hematopoietic precursors. CD133 + stem cells might be useful for research and for clinical application.
    Type of Medium: Online Resource
    ISSN: 0077-8923 , 1749-6632
    URL: Issue
    URL: Article
    DOI: 10.1111/nyas.2003.996.issue-1
    DOI: 10.1111/j.1749-6632.2003.tb03242.x
    RVK:
    TD 7650
    Language: English
    Publisher: Wiley
    Publication Date: 2003
    detail.hit.zdb_id: 2834079-6
    detail.hit.zdb_id: 211003-9
    detail.hit.zdb_id: 2071584-5
    SSG: 11
    Location Call Number Limitation Availability
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  • 3
    Online Resource
    Online Resource
    Making evolutionary biology a basic science for medicine
    Proceedings of the National Academy of Sciences ; 2010
    In:  Proceedings of the National Academy of Sciences Vol. 107, No. suppl_1 ( 2010-01-26), p. 1800-1807
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 107, No. suppl_1 ( 2010-01-26), p. 1800-1807
    Abstract: New applications of evolutionary biology in medicine are being discovered at an accelerating rate, but few physicians have sufficient educational background to use them fully. This article summarizes suggestions from several groups that have considered how evolutionary biology can be useful in medicine, what physicians should learn about it, and when and how they should learn it. Our general conclusion is that evolutionary biology is a crucial basic science for medicine. In addition to looking at established evolutionary methods and topics, such as population genetics and pathogen evolution, we highlight questions about why natural selection leaves bodies vulnerable to disease. Knowledge about evolution provides physicians with an integrative framework that links otherwise disparate bits of knowledge. It replaces the prevalent view of bodies as machines with a biological view of bodies shaped by evolutionary processes. Like other basic sciences, evolutionary biology needs to be taught both before and during medical school. Most introductory biology courses are insufficient to establish competency in evolutionary biology. Premedical students need evolution courses, possibly ones that emphasize medically relevant aspects. In medical school, evolutionary biology should be taught as one of the basic medical sciences. This will require a course that reviews basic principles and specific medical applications, followed by an integrated presentation of evolutionary aspects that apply to each disease and organ system. Evolutionary biology is not just another topic vying for inclusion in the curriculum; it is an essential foundation for a biological understanding of health and disease.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.0906224106
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2010
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
    SSG: 11
    SSG: 12
    Location Call Number Limitation Availability
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