In:
American Journal of Rhinology & Allergy, SAGE Publications, Vol. 28, No. 6 ( 2014-11), p. e197-e201
Abstract:
IL-22 regulates various processes and has been linked to diverse effects. However, the importance of IL-22 in the pathogenesis of allergic rhinitis (AR) remains poorly understood. This study sought to evaluate the levels of IL-22 and IL-17A in AR patients and their association with clinical severity of AR. Methods Thirty-six AR patients and 22 normal controls were enrolled in this study. The frequencies of IL-22 + , IL-17A + , and IL-9 + T helper (Th) cells in peripheral blood of AR patients and normal controls were examined by flow cytometry. Serum levels of IL-22 and IL-17A in AR patients and normal controls were determined by ELISA. The clinical relevance of the percentages of IL-22 + and IL-17A + Th cells as well as serum IL-22 and IL-17A levels were evaluated. Results The frequencies of IL-22 + and IL-17A + Th cells, but not IL-9 + Th cells, were significantly increased compared with those in normal controls (p 〈 0.05). Frequencies of IL-22 + and IL-17A + Th cells in peripheral blood of AR patients significantly correlated with visual analog scale scores of nasal symptoms (nasal congestion and rhinorrhea; p 〈 0.05). Moreover, the serum levels of IL-22 and IL-1 were significantly increased compared with those in normal controls (p 〈 0.05) and significantly correlated with the levels of Dermatophagoides pteronyssinus and Dermatophagoides farinae specific IgE in AR patients. Conclusion Our findings suggested that IL-22 as well as IL-17A may play an important role in the regulation of Th2-skewed inflammation in AR patients.
Type of Medium:
Online Resource
ISSN:
1945-8924
,
1945-8932
DOI:
10.2500/ajra.2014.28.4088
Language:
English
Publisher:
SAGE Publications
Publication Date:
2014
detail.hit.zdb_id:
2554548-6
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