In:
International Journal of Cancer, Wiley, Vol. 145, No. 10 ( 2019-11-15), p. 2728-2739
Abstract:
What's new? Alternative splicing is a highly complicated process that not only regulates gene expression but also increases protein diversity. Dysregulation of CHERP—a protein belonging to the spliceosome and related to the core component U2—has been implicated in several cancers, but it remains elusive how CHERP contributes to cancer cell proliferation and cancer development. This study provides substantial insight into the biological significance of CHERP and its binding partner SR140 in colorectal tumorigenesis and identifies the RNA surveillance factor UPF3A as their key splicing target for mediating and maintaining oncogenic phenotypes of human colon cancer cells.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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