In:
International Journal of Cancer, Wiley, Vol. 145, No. 8 ( 2019-10-15), p. 2225-2237
Abstract:
What's new? Myeloid‐derived suppressor cells (MDSCs) play a critical role in enabling tumor immune escape. Factors capable of counteracting MDSC activity in the tumor microenvironment remain largely unknown. Here, the authors identify caspase recruitment domain‐containing protein 9 (CARD9), a myeloid cell adaptor protein, as an inhibitor of MDSCs and indoleamine 2,3‐dioxygenase (IDO), an immunosuppressive enzyme produced by MDSCs. In mice, CARD deficiency was associated with increased lung tumor size and impaired immune response. Non‐canonical NF‐kB pathway signaling and IDO expression were enhanced in CARD‐deficient cells. The findings suggest that CARD9 is an important immune regulator in the lung tumor microenvironment.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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